| 1. |
- Hölttä, V., et al.
(författare)
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Lean information management model for engineering changes
- 2010
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Ingår i: Proceedings of World Academy of Science, Engineering and Technology. - 2010-376X .- 2070-3740. ; 42, s. 1459-1466
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Tidskriftsartikel (refereegranskat)abstract
- Poor engineering change management (ECM) can cause slow and uncontrollable product development projects. Engineering changes (ECs) create a need for efficient information exchange between the companies in the supply chain. Four case studies were conducted in the heavy machinery, mechatronics, and automotive industries to identify the current challenges in ECM. A comparison between the challenges of ECM and the principles of lean product development (LPD) indicates that fulfilling these principles will generate a better ECM process. The LPD principles were applied to information management to create a model for lean information management (LIM). The purpose of this model is to make ECM more efficient. The initial results of these implementations suggest that the lead times of information transfer can be reduced using this approach. The LIM principles presented in our model will address most of the challenges in ECM.
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| 2. |
- Lahdenperä, Anna, et al.
(författare)
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Up-regulation of small intestinal interleukin-17 immunity in untreated coeliac disease but not in potential coeliac disease or in type 1 diabetes
- 2012
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Ingår i: Clinical and Experimental Immunology. - : John Wiley & Sons. - 0009-9104 .- 1365-2249. ; 167:2, s. 226-234
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Tidskriftsartikel (refereegranskat)abstract
- Up-regulation of interleukin (IL)-17 in small intestinal mucosa has been reported in coeliac disease (CD) and in peripheral blood in type 1 diabetes (T1D). We explored mucosal IL-17 immunity in different stages of CD, including transglutaminase antibody (TGA)-positive children with potential CD, children with untreated and gluten-free diet-treated CD and in children with T1D. Immunohistochemistry was used for identification of IL-17 and forkhead box protein 3 (FoxP3)-positive cells and quantitative polymerase chain reaction (qPCR) for IL-17, FoxP3, retinoic acid-related orphan receptor (ROR)c and interferon (IFN)-γ transcripts. IL-1β, IL-6 and IL-17 were studied in supernatants from biopsy cultures. Expression of the apoptotic markers BAX and bcl-2 was evaluated in IL-17-stimulated CaCo-2 cells. The mucosal expression of IL-17 and FoxP3 transcripts were elevated in individuals with untreated CD when compared with the TGA-negative reference children, children with potential CD or gluten-free diet-treated children with CD (P andlt; 0·005 for all IL-17 comparisons and P andlt; 0·01 for all FoxP3 comparisons). The numbers of IL-17-positive cells were higher in lamina propria in children with CD than in children with T1D (P andlt; 0·05). In biopsy specimens from patients with untreated CD, enhanced spontaneous secretion of IL-1β, IL-6 and IL-17 was seen. Activation of anti-apoptotic bcl-2 in IL-17-treated CaCo-2 epithelial cells suggests that IL-17 might be involved in mucosal protection. Up-regulation of IL-17 could, however, serve as a biomarker for the development of villous atrophy and active CD.
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