| 1. |
- Abrahamyan, Lilit, et al.
(författare)
-
A Problem Solving Environment for Image-Based Computational Hemodynamics
- 2005
-
Konferensbidrag (refereegranskat)abstract
- We introduce a complete problem solving environment designed for pulsatile flows in 3D complex geometries, especially arteries. Three-dimensional images from arteries, obtained from e.g. Magnetic Resonance Imaging, are segmented to obtain a geometrical description of the arteries of interest. This segmented artery is prepared for blood flow simulations in a 3D editing tool, allowing to define in- and outlets, to filter and crop part of the artery, to add certain structures ( e.g. a by-pass, or stents ), and to generate computational meshes as input to the blood flow simulators. Using dedicated fluid flow solvers the time dependent blood flow in the artery during one systole is computed. The resulting flow, pressure and shear stress fields are then analyzed using a number of visualization techniques. The whole environment can be operated from a desktop virtual reality system, and is embedded in a Grid computing environment.
|
|
| 2. |
- Stoel, Berend C., et al.
(författare)
-
Eureka?
- 2011
-
Ingår i: Radiology. - : Radiological Society of North America (RSNA). - 1527-1315 .- 0033-8419. ; 259:2, s. 610-611
-
Tidskriftsartikel (refereegranskat)
|
|
| 3. |
- Stolk, Jan, et al.
(författare)
-
Progression parameters for emphysema: A clinical investigation
- 2007
-
Ingår i: Respiratory Medicine. - : Elsevier BV. - 1532-3064 .- 0954-6111. ; 101:9, s. 1924-1930
-
Tidskriftsartikel (refereegranskat)abstract
- In patients with airflow limitation caused by cigarette smoking, lung density measured by computed tomography is strongly correlated with quantitative pathology scores of emphysema, but the ability of lung densitometry to detect progression of emphysema is disputed. We assessed the sensitivity of lung densitometry as a parameter of disease progression of emphysema in comparison to FEV1 and gas transfer. At study baseline and after 30 months we measured computed tomography (CT)-derived lung density, spirometry and carbon monoxide diffusion coefficient in 144 patients with chronic obstructive pulmonary disease (COPD) in five different centers. Annual change in lung density was 1.31 g/L/year (CI 95%: -2.12 to -0.50 HU, p = 0.0015, 39.5 mL/year (CI 95%: -100.0-21.0 mL, p = 0.2) for FEV1, (-39.5 mL) and 24.3 mu mol/min/kPa/L/year for gas transfer (CI 95%: -61.0-12.5 mu mol/min/kPa/L/year, p = 0.2). Signal-to-noise ratio (mean change divided by standard error of the change) for the detection of annual change was 3.2 for lung densitometry, but 1.3 for both FEV1 and gas diffusion. We conclude that detection of progression of emphysema was found to be 2.5-fold more sensitive using lung densitometry than by using currently recommended lung function parameters. Our results support CT scan as an efficacious test for novel drugs for emphysema. (c) 2007 Published by Elsevier Ltd.
|
|
