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Sökning: WFRF:(HINKULA J)

  • Resultat 1-10 av 88
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  • Arteaga, H J, et al. (författare)
  • Choosing CCR5 or Rev siRNA in HIV-1
  • 2003
  • Ingår i: Nature Biotechnology. - : Springer Science and Business Media LLC. - 1087-0156 .- 1546-1696. ; 21:3, s. 230-231
  • Tidskriftsartikel (refereegranskat)
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  • Timpka, Toomas, et al. (författare)
  • Predictive performance of telenursing complaints in influenza surveillance : a prospective cohort study in Sweden
  • 2014
  • Ingår i: Eurosurveillance. - 1025-496X .- 1560-7917. ; 19:46, s. 20966-
  • Tidskriftsartikel (refereegranskat)abstract
    • Syndromic data sources have been sought to improve the timely detection of increased influenza transmission. This study set out to examine the prospective performance of telenursing chief complaints in predicting influenza activity. Data from two influenza seasons (2007/08 and 2008/09) were collected in a Swedish county (population 427,000) to retrospectively determine which grouping of telenursing chief complaints had the largest correlation with influenza case rates. This grouping was prospectively evaluated in the three subsequent seasons. The best performing telenursing complaint grouping in the retrospective algorithm calibration was fever (child, adult) and syncope (r=0.66; p<0.001). In the prospective evaluation, the performance of 14-day predictions was acceptable for the part of the evaluation period including the 2009 influenza pandemic (area under the curve (AUC)=0.84; positive predictive value (PPV)=0.58), while it was strong (AUC=0.89; PPV=0.93) for the remaining evaluation period including only influenza winter seasons. We recommend the use of telenursing complaints for predicting winter influenza seasons. The method requires adjustments when used during pandemics.
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  • Veldhuis Kroeze, Edwin J. B., et al. (författare)
  • Consecutive CT in vivo lung imaging as quantitative parameter of influenza vaccine efficacy in the ferret model
  • 2012
  • Ingår i: Vaccine. - : Elsevier. - 0264-410X .- 1873-2518. ; 30:51, s. 7391-7394
  • Tidskriftsartikel (refereegranskat)abstract
    • Preclinical vaccine efficacy studies are generally limited to certain read out parameters such as assessment of virus titers in swabs and organs, clinical signs, serum antibody titers, and pathological changes. These parameters are not always routinely applied and not always scheduled in a logical standardized way. We used computed tomography (CT) imaging as additional and novel read out parameter in a vaccine efficacy study by quantifying alterations in aerated lung volumes in ferrets challenged with the 2009 pandemic A/H1N1 influenza virus.Vaccination protected from marked variations in aerated lung volumes compared to naive controls. The vaccinated group showed a daily gradual mean reduction with a maximum of 7.8%, whereas the controls showed a maximum of 14.3% reduction. The pulmonary opacities evident on CT images were most pronounced in the placebo-treated controls, and corresponded to significantly increased relative lung weights at necropsy.This study shows that consecutive in vivo CT imaging allows for a day to day read out of vaccine efficacy by quantification of altered aerated lung volumes. 
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  • Resultat 1-10 av 88

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