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Search: WFRF:(HJELTE L)

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  • Al Shakirchi, M, et al. (author)
  • The Effects of Aspergillus fumigatus Colonization on Lung Function in Patients with Cystic Fibrosis
  • 2021
  • In: Journal of fungi (Basel, Switzerland). - : MDPI AG. - 2309-608X. ; 7:11
  • Journal article (peer-reviewed)abstract
    • Aspergillus fumigatus is commonly isolated from CF airways. However, the impact on CF lung progression is not completely understood. In this study, using a 16-year retrospective observational cohort study (2000–2015) that included 132 patients, we determined the annual lung function, measured as percent predicted forced expiratory volume in the first second (ppFEV1), decline before and after the first colonization with A. fumigatus. Further, in the same individual, the ratios of lung function when patients were colonized with A. fumigatus and when they were not were calculated. The impact of eradication, with antifungal treatment or spontaneously, was assessed. The annual ppFEV1 was significantly lower after the first colonization with A. fumigatus. Furthermore, within the same individual, colonization with A. fumigatus for two and three years in a row was associated with 4.3% and 7.9% lower ppFEV1, respectively, compared to when not colonized. Finally, patients who eradicated A. fumigatus the following two years after colonization exhibited 9.9% and 14.5% higher ppFEV1 compared to patients who continued to produce cultures with A. fumigatus for two and three years. Our study demonstrated that A. fumigatus colonization was associated with a negative impact on lung function in the long term and eradication, spontaneously or with treatment, was associated with a better pulmonary outcome.
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  • De Brito, A. N., et al. (author)
  • Evidence against atomiclike resonant auger decay in N2 doubly excited core states by high-resolution experiments
  • 2001
  • In: Physical Review A. Atomic, Molecular, and Optical Physics. - 1050-2947. ; 64:5, s. 547021-547024
  • Journal article (peer-reviewed)abstract
    • The resonant Auger decay spectra associated with doubly excited core-hole states near the N 1s threshold in the nitrogen molecule was measured. Electron-yield spectrum was obtained by setting a kinetic-energy window at 384 eV and scanning across the threshold region. At ground 410, 414, and 416 eV, photon energy, three dominant structures were observed. The increased signal-to-background ratio, intensity and resolution at third generation facilities were found to cast a different light on the dynamics of core photoionization in molecules.
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  • Result 1-10 of 102

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