| 1. |
- Albert, Christian, et al.
(författare)
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Neutrophil Gelatinase-Associated Lipocalin Measured on Clinical Laboratory Platforms for the Prediction of Acute Kidney Injury and the Associated Need for Dialysis Therapy : A Systematic Review and Meta-analysis
- 2020
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Ingår i: American Journal of Kidney Diseases. - : Elsevier BV. - 0272-6386 .- 1523-6838. ; 76:6, s. 826-
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Forskningsöversikt (refereegranskat)abstract
- Rationale & Objective: The usefulness of measures of neutrophil gelatinase-associated lipocalin (NGAL) in urine or plasma obtained on clinical laboratory platforms for predicting acute kidney injury (AKI) and AKI requiring dialysis (AKI-D) has not been fully evaluated. We sought to quantitatively summarize published data to evaluate the value of urinary and plasma NGAL for kidney risk prediction.Study Design: Literature-based meta-analysis and individual-study-data meta-analysis of diagnostic studies following PRISMA-IPD guidelines.Setting & Study Populations: Studies of adults investigating AKI, severe AKI, and AKI-D in the setting of cardiac surgery, intensive care, or emergency department care using either urinary or plasma NGAL measured on clinical laboratory platforms.Selection Criteria for Studies: PubMed, Web of Science, Cochrane Library, Scopus, and congress abstracts ever published through February 2020 reporting diagnostic test studies of NGAL measured on clinical laboratory platforms to predict AKI.Data Extraction: Individual-study-data meta analysis was accomplished by giving authors data specifications tailored to their studies and requesting standardized patient-level data analysis.Analytical Approach: Individual-study-data meta analysis used a bivariate time-to-event model for interval-censored data from which discriminative ability (AUC) was characterized. NGAL cutoff concentrations at 95% sensitivity, 95% specificity, and optimal sensitivity and specificity were also estimated. Models incorporated as confounders the clinical setting and use versus nonuse of urine output as a criterion for AKI. A literature-based meta-analysis was also performed for all published studies including those for which the authors were unable to provide individual-study data analyses.Results: We included 52 observational studies involving 13,040 patients. We analyzed 30 data sets for the individual-study-data meta-analysis. For AKI, severe AKI, and AKI-D, numbers of events were 837, 304, and 103 for analyses of urinary NGAL, respectively; these values were 705, 271, and 178 for analyses of plasma NGAL. Discriminative performance was similar in both meta-analyses. Individual-study-data meta-analysis AUCs for urinary NGAL were 0.75 (95% CI, 0.73-0.76) and 0.80 (95% CI, 0.79-0.81) for severe AKI and AKI-D, respectively; for plasma NGAL, the corresponding AUCs were 0.80 (95% CI, 0.790.81) and 0.86 (95% CI, 0.84-0.8 6). Cutoff concentrations at 95% specificity for urinary NGAL were >580 ng/mL with 27% sensitivity for severe AKI and >589 ng/mL with 24% sensitivity for AKI-D. Corresponding cutoffs for plasma NGAL were >364 ng/mL with 44% sensitivity and >546 ng/mL with 26% sensitivity, respectively.Limitations: Practice variability in initiation of dialysis. Imperfect harmonization of data across studies. Conclusions: Urinary and plasma NGAL concentrations may identify patients at high risk for AKI in clinical research and practice. The cutoff concentrations reported in this study require prospective evaluation.
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| 2. |
- Idoia Biurrun, Idoia, et al.
(författare)
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GrassPlot v. 2.00 – first update on the database of multi-scale plant diversity in Palaearctic grasslands
- 2019
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Ingår i: Palaearctic Grasslands. - : Eurasian Dry Grassland Group (EDGG). - 2627-9827. ; :44, s. 26-47
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Tidskriftsartikel (refereegranskat)abstract
- GrassPlot is a collaborative vegetation-plot database organised by the Eurasian Dry Grassland Group (EDGG) and listed in the Global Index of Vegetation-Plot Databases (GIVD ID EU-00-003). Following a previous Long Database Report (Dengler et al. 2018, Phytocoenologia 48, 331–347), we provide here the first update on content and functionality of GrassPlot. The current version (GrassPlot v. 2.00) contains a total of 190,673 plots of different grain sizes across 28,171 independent plots, with 4,654 nested-plot series including at least four grain sizes. The database has improved its content as well as its functionality, including addition and harmonization of header data (land use, information on nestedness, structure and ecology) and preparation of species composition data. Currently, GrassPlot data are intensively used for broad-scale analyses of different aspects of alpha and beta diversity in grassland ecosystems.
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| 3. |
- Lembrechts, Jonas J., et al.
(författare)
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SoilTemp : A global database of near-surface temperature
- 2020
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Ingår i: Global Change Biology. - : Wiley. - 1354-1013 .- 1365-2486. ; 26:11, s. 6616-6629
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Tidskriftsartikel (refereegranskat)abstract
- Current analyses and predictions of spatially explicit patterns and processes in ecology most often rely on climate data interpolated from standardized weather stations. This interpolated climate data represents long-term average thermal conditions at coarse spatial resolutions only. Hence, many climate-forcing factors that operate at fine spatiotemporal resolutions are overlooked. This is particularly important in relation to effects of observation height (e.g. vegetation, snow and soil characteristics) and in habitats varying in their exposure to radiation, moisture and wind (e.g. topography, radiative forcing or cold-air pooling). Since organisms living close to the ground relate more strongly to these microclimatic conditions than to free-air temperatures, microclimatic ground and near-surface data are needed to provide realistic forecasts of the fate of such organisms under anthropogenic climate change, as well as of the functioning of the ecosystems they live in. To fill this critical gap, we highlight a call for temperature time series submissions to SoilTemp, a geospatial database initiative compiling soil and near-surface temperature data from all over the world. Currently, this database contains time series from 7,538 temperature sensors from 51 countries across all key biomes. The database will pave the way toward an improved global understanding of microclimate and bridge the gap between the available climate data and the climate at fine spatiotemporal resolutions relevant to most organisms and ecosystem processes.
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| 4. |
- Biurrun, Idoia, et al.
(författare)
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Benchmarking plant diversity of Palaearctic grasslands and other open habitats
- 2021
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Ingår i: Journal of Vegetation Science. - Oxford : John Wiley & Sons. - 1100-9233 .- 1654-1103. ; 32:4
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Tidskriftsartikel (refereegranskat)abstract
- Journal of Vegetation Science published by John Wiley & Sons Ltd on behalf of International Association for Vegetation Science.Aims: Understanding fine-grain diversity patterns across large spatial extents is fundamental for macroecological research and biodiversity conservation. Using the GrassPlot database, we provide benchmarks of fine-grain richness values of Palaearctic open habitats for vascular plants, bryophytes, lichens and complete vegetation (i.e., the sum of the former three groups). Location: Palaearctic biogeographic realm. Methods: We used 126,524 plots of eight standard grain sizes from the GrassPlot database: 0.0001, 0.001, 0.01, 0.1, 1, 10, 100 and 1,000 m2 and calculated the mean richness and standard deviations, as well as maximum, minimum, median, and first and third quartiles for each combination of grain size, taxonomic group, biome, region, vegetation type and phytosociological class. Results: Patterns of plant diversity in vegetation types and biomes differ across grain sizes and taxonomic groups. Overall, secondary (mostly semi-natural) grasslands and natural grasslands are the richest vegetation type. The open-access file ”GrassPlot Diversity Benchmarks” and the web tool “GrassPlot Diversity Explorer” are now available online (https://edgg.org/databases/GrasslandDiversityExplorer) and provide more insights into species richness patterns in the Palaearctic open habitats. Conclusions: The GrassPlot Diversity Benchmarks provide high-quality data on species richness in open habitat types across the Palaearctic. These benchmark data can be used in vegetation ecology, macroecology, biodiversity conservation and data quality checking. While the amount of data in the underlying GrassPlot database and their spatial coverage are smaller than in other extensive vegetation-plot databases, species recordings in GrassPlot are on average more complete, making it a valuable complementary data source in macroecology. © 2021 The Authors.
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| 5. |
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| 6. |
- Baumeister, Barbara, et al.
(författare)
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Polytopes associated to dihedral groups
- 2014
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Ingår i: Ars Mathematica Contemporanea. - : University of Primorska Press. - 1855-3966 .- 1855-3974. ; 7:1, s. 30-38
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Tidskriftsartikel (refereegranskat)abstract
- In this note we investigate the convex hull of those n × n permutation matrices that correspond to symmetries of a regular n-gon. We give the complete facet description. As an application, we show that this yields a Gorenstein polytope, and we determine the Ehrhart h * -vector.
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| 7. |
- Beck, Matthias, et al.
(författare)
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Smooth Centrally Symmetric Polytopes in Dimension 3 are IDP
- 2019
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Ingår i: Annals of Combinatorics. - : Springer Publishing Company. - 0218-0006 .- 0219-3094. ; 23:2, s. 255-262
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Tidskriftsartikel (refereegranskat)abstract
- In 1997 Oda conjectured that every smooth lattice polytope has the integer decomposition property. We prove Oda's conjecture for centrally symmetric 3-dimensional polytopes, by showing they are covered by lattice parallelepipeds and unimodular simplices.
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| 8. |
- Bogart, Tristram, et al.
(författare)
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Finitely many smooth d-polytopes with n lattice points
- 2015
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Ingår i: Israel Journal of Mathematics. - : Springer Science and Business Media LLC. - 0021-2172 .- 1565-8511. ; 207:1, s. 301-329
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Tidskriftsartikel (refereegranskat)abstract
- We prove that for fixed n there are only finitely many embeddings of ℚ-factorial toric varieties X into ℙ n that are induced by a complete linear system. The proof is based on a combinatorial result that implies that for fixed nonnegative integers d and n, there are only finitely many smooth d-polytopes with n lattice points. We also enumerate all smooth 3-polytopes with ≤ 12 lattice points.
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| 9. |
- Di Rocco, Sandra, et al.
(författare)
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A note on discrete mixed volume and Hodge-Deligne numbers
- 2019
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Ingår i: Advances in Applied Mathematics. - : ACADEMIC PRESS INC ELSEVIER SCIENCE. - 0196-8858 .- 1090-2074. ; 104, s. 1-13
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Tidskriftsartikel (refereegranskat)abstract
- Generalizing the famous Bernstein-Kushnirenko theorem, Khovanskii proved in 1978 a combinatorial formula for the arithmetic genus of the compactification of a generic complete intersection associated to a family of lattice polytopes. Recently, an analogous combinatorial formula, called the discrete mixed volume, was introduced by Bihan and shown to be nonnegative. By making a footnote of Khovanskii in his paper explicit, we interpret this invariant as the (motivic) arithmetic genus of the non-compact generic complete intersection associated to the family of lattice polytopes.
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| 10. |
- Di Rocco, Sandra, et al.
(författare)
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Polyhedral adjunction theory
- 2013
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Ingår i: Algebra & Number Theory. - : Mathematical Sciences Publishers. - 1937-0652 .- 1944-7833. ; 7:10, s. 2417-2446
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Tidskriftsartikel (refereegranskat)abstract
- In this paper we offer a combinatorial view on the adjunction theory of toric varieties. Inspired by classical adjunction theory of polarized algebraic varieties we explore two convex-geometric notions: the Q-codegree and the nef value of a rational polytope P. We prove a structure theorem for lattice polytopes P with large Q-codegree. For this, we define the adjoint polytope P-(s) as the set of those points in P whose lattice distance to every facet of P is at least s. It follows from our main result that if P-(s) is empty for some s < 2/(dim P + 2), then the lattice polytope P has lattice width one. This has consequences in Ehrhart theory and on polarized toric varieties with dual defect. Moreover, we illustrate how classification results in adjunction theory can be translated into new classification results for lattice polytopes.
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