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- Adolfsson, Annsofie, 1960-, et al.
(författare)
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How Vaginal Infections Impact Women's Everyday Life : Women's Lived Experiences of Bacterial Vaginosis and Recurrent Vulvovaginal Candidiasis
- 2017
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Ingår i: Advances in Sexual Medicine. - Irvine, USA : Scientific Research Publishing. - 2164-5191 .- 2164-5205. ; 7:1, s. 1-19
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Tidskriftsartikel (refereegranskat)abstract
- Reoccurring symptoms and persistent problems that continue post treatment can becharacteristic of the vaginal infections Bacterial Vaginosis (BV) and recurrent vulvovaginalcandidiasis (RVVC). The purpose of this study was to describe women’s lifeexperiences in managing the symptoms of bacterial vaginosis and Candida. Sixteenwomen were recruited and participated in an interview study when they contacted aSwedish gynecology clinic with vaginal complaints that ranged from and includedabnormal discharge, irritation itching along with serious malodor. An interpretivephenomenological approach was used with an individual interview to get a more intimateunderstanding of the women experiencing these problems. The finding of thisstudy shows that managing the recurrent symptoms of the infections remains to be achallenge for women as it has a clearly negative impact on the quality of their lives.Four themes developed: frustration and mood disorders, intimacy changes in the relationship,exposure, hope and relief. The women had high hopes of eliminating thesymptoms within the six-month study period. The treatment program, with itswell-developed guidelines and continuity of care within the context of the studygreatly improved the quality of life of these women. Women had feelings of frustrationand anxiety when nothing could cure their problem while they had also a greathope to get rid of the symptoms with a long striking treatment. Well-developedguidelines and continuity of care can help these women to have an improved qualityof life.
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- Axelsson, Jan Peter, et al.
(författare)
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A Probing Approach for Detection of Acetate Formation
- 1998
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Konferensbidrag (refereegranskat)abstract
- Many pharmaceuticals are today produced using genetically modified microorganisms. A typical problem in monitoring and control of biotechnical processes is that many important process variables cannot be measured on-line. This has triggered much research and development concerning new sensors. Another way of addressing the problem is to improve and to extend the use of existing sensors.
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- Axelsson, Jan Peter, et al.
(författare)
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A Probing Feeding Strategy for E. coli Cultivations
- 1999
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Ingår i: Abstract book of 217th ACS National Meeting.
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Konferensbidrag (refereegranskat)abstract
- Accumulation of acetate tends to reduce growth and recombinant protein production in E. coli cultivations. Formation of acetate can be avoided by a proper substrate feeding strategy, but most strategies require considerable process knowledge to work well. A feedback strategy is presented that requires minimal a priori information. The key idea is to exploit a characteristic change in the cell metabolism at the onset of acetate formation. By superimposing short pulses in the substrate feed rate, on-line detection of acetate formation can be made using a standard dissolved oxygen sensor. A simple feedback algorithm is then used to adjust the feed rate to avoid acetate formation while maintaining a high growth rate. The strategy was used in fed-batch cultivations of recombinant E. coli. Acetate accumulation was avoided and a good production of recombinant protein could be achieved at the first attempt for each genetic construction.
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- Axelsson, Jan Peter, et al.
(författare)
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A Probing Feeding Strategy for Escherichia coli Cultures
- 1999
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Ingår i: Biotechnology Techniques. - 0951-208X. ; 13, s. 523-528
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Tidskriftsartikel (refereegranskat)abstract
- A strain-independent feeding strategy for fed-batch cultures of Escherichia coli is presented. The key idea is to exploit a characteristic change in the cell metabolism at the onset of acetate formation. By superimposing short pulses in the glucose feed rate, on-line detection of acetate formation can be made using a standard dissolved oxygen sensor. A simple feedback algorithm is then used to adjust the feed rate to avoid acetate formation. The feasibility of the strategy is demonstrated by both simulation and experiments.
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