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Träfflista för sökning "WFRF:(Hagglof A) "

Search: WFRF:(Hagglof A)

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  • Enoksson, SL, et al. (author)
  • The inflammatory cytokine IL-18 induces self-reactive innate antibody responses regulated by natural killer T cells
  • 2011
  • In: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 1091-6490. ; 108:51, s. E1399-E1407
  • Journal article (peer-reviewed)abstract
    • Inflammatory responses initiate rapid production of IL-1 family cytokines, including IL-18. This cytokine is produced at high levels in inflammatory diseases, including allergy and autoimmunity, and is known to induce IgE production in mice. Here we provide evidence that IL-18 is directly coupled to induction of self-reactive IgM and IgG antibody responses and recruitment of innate B2 B cells residing in the marginal zone of the spleen. Moreover, the data suggest that the B-cell activation occurs predominantly in splenic extrafollicular plasma cell foci and is regulated by natural killer T (NKT) cells that prevent formation of mature germinal centers. We also find evidence that NKT cells control this type of B-cell activation via cytotoxicity mediated by both the perforin and CD95/CD178 pathways. Thus, NKT cells regulate innate antibody responses initiated by an inflammatory stimulus, suggesting a general mechanism that regulates B-cell behavior in inflammation and autoreactivity.
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  • Strandberg, Karin, et al. (author)
  • Fyra nya instrument för analys av blodgaser testade: Behändiga kassetter skall ge bättre användarvänlighet
  • 2000
  • In: Läkartidningen. - : Swedish Medical Association. - 0023-7205 .- 1652-7518. ; 97:7, s. 698-701
  • Journal article (peer-reviewed)abstract
    • An entirely new type of blood gas analyser has made its way into the marketplace, to be used, for example, in emergency rooms, intensive care units, ambulances, and bedside with quarantined patients in infectious diseases units. The instruments reviewed here employ new miniaturised analysis circuitry, integrated into the cassette on which the blood sample is applied. These instruments are designed for use by care-givers without specific laboratory training. Four point-of-care blood gas analysers are tested: OPTI 1 (AVL), I-STAT (HP), IRMA (Infiniti) och ABL 70 (Radiometer).
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  • Result 1-7 of 7

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