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- Tjonneland, A., et al.
(författare)
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Linoleic acid, a dietary n-6 polyunsaturated fatty acid, and the aetiology of ulcerative colitis: a nested case-control study within a European prospective cohort study
- 2009
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Ingår i: Gut. - : BMJ. - 1468-3288 .- 0017-5749. ; 58:12, s. 1606-1611
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Tidskriftsartikel (refereegranskat)abstract
- Objective: Dietary linoleic acid, an n-6 polyunsaturated fatty acid, is metabolised to arachidonic acid, a component of colonocyte membranes. Metabolites of arachidonic acid have pro-inflammatory properties and are increased in the mucosa of patients with ulcerative colitis. The aim of this investigation was to conduct the first prospective cohort study investigating if a high dietary intake of linoleic acid increases the risk of developing incident ulcerative colitis. Design and setting: Dietary data from food frequency questionnaires were available for 203 193 men and women aged 30-74 years, resident in the UK, Sweden, Denmark, Germany or Italy and participating in a prospective cohort study, the European Prospective Investigation into Cancer and Nutrition (EPIC). These participants were followed up for the diagnosis of ulcerative colitis. Each case was matched with four controls and the risk of disease calculated by quartile of intake of linoleic acid adjusted for gender, age, smoking, total energy intake and centre. Results: A total of 126 participants developed ulcerative colitis (47% women) after a median follow-up of 4.0 years (range, 1.7-11.3 years). The highest quartile of intake of linoleic acid was associated with an increased risk of ulcerative colitis (odds ratio (OR) = 2.49, 95% confidence interval (CI) = 1.23 to 5.07, p = 0.01) with a significant trend across quartiles (OR = 1.32 per quartile increase, 95% CI = 1.04 to 1.66, p = 0.02 for trend). Conclusions: The data support a role for dietary linoleic acid in the aetiology of ulcerative colitis. An estimated 30% of cases could be attributed to having dietary intakes higher than the lowest quartile of linoleic acid intake.
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| 5. |
- Hagglund, G., et al.
(författare)
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Bilaterality in slipped upper femoral epiphysis
- 1988
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Ingår i: Journal of Bone and Joint Surgery - Series B. - 0301-620X. ; 70:2, s. 179-181
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Tidskriftsartikel (refereegranskat)abstract
- The frequency of slipping and osteoarthritis of the contralateral hip was recorded in 260 patients with slipped upper femoral epiphysis between 1910 and 1960. Twenty-three of these patients (9%) had primary bilateral slipping, 32 (12%) had a contralateral slip diagnosed later during adolescence and a further 104 (40%) had signs of contralateral slipping at follow-up 16 to 66 years later, giving a total of 159 cases (61%) with bilateral slips. Of the 104 slippings diagnosed at follow-up, 25% showed osteoarthirits. it is concluded that, with a slipped epiphysis, prophylactic contralateral pinning should be performed to avoid slipping and to reduce the risk of osteoarthritis.
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| 6. |
- Hagglund, G., et al.
(författare)
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Bone growth after fixing slipped femoral epiphyses : Brief report
- 1988
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Ingår i: Journal of Bone and Joint Surgery - Series B. - 0301-620X. ; 70:5, s. 845-846
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Tidskriftsartikel (refereegranskat)abstract
- Early closure of the growth plate after fixing a slipped upper femoral epiphysis is often regarded as favourable since, if growth of the femoral neck continues, the metal may lose its grip on the epiphysis with the possibility of further slipping. However, in the young child early fusion may result in leg length discrepancy and limited motion. The hook-pin (Hansson 1982) permits continued growth of the femoral neck without the risk of further slipping, as illustrated in the following cases.
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| 8. |
- Johnsson, R., et al.
(författare)
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Autogenic bone paste in posterolateral fusion of the lower lumbar spine
- 1990
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Ingår i: Journal of Orthopaedic Surgical Techniques. - 0334-0236. ; 5:1, s. 19-25
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Tidskriftsartikel (refereegranskat)abstract
- In order to facilitate bone graft harvesting and to get more mouldable bone graft in posterolateral fusions of the lower lumbar spine, a modified technique of bone graft harvesting was utilized. Through a midline skin incision the most posterolateral part of an iliac crest was ground with a reamer to a smooth bone paste. The technique was used in lumbar posterolateral fusions without osteosynthesis in 13 patients with no previous spinal surgery and with spondylolysis-olisthesis grade 1-4 or lumbar disc disorder/facet joint arthrosis. Conventional radiography 6-9 months after surgery demonstrated good osseous consolidation of the fusion in 11 patients. There was no postoperative infection and the patients profited from having only 1 scar instead of 2 or 3.
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