| 1. |
- Berndt, Sonja I., et al.
(författare)
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Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture
- 2013
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 45:5, s. 501-U69
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Tidskriftsartikel (refereegranskat)abstract
- Approaches exploiting trait distribution extremes may be used to identify loci associated with common traits, but it is unknown whether these loci are generalizable to the broader population. In a genome-wide search for loci associated with the upper versus the lower 5th percentiles of body mass index, height and waist-to-hip ratio, as well as clinical classes of obesity, including up to 263,407 individuals of European ancestry, we identified 4 new loci (IGFBP4, H6PD, RSRC1 and PPP2R2A) influencing height detected in the distribution tails and 7 new loci (HNF4G, RPTOR, GNAT2, MRPS33P4, ADCY9, HS6ST3 and ZZZ3) for clinical classes of obesity. Further, we find a large overlap in genetic structure and the distribution of variants between traits based on extremes and the general population and little etiological heterogeneity between obesity subgroups.
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| 2. |
- Locke, Adam E, et al.
(författare)
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Genetic studies of body mass index yield new insights for obesity biology.
- 2015
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 518:7538, s. 197-401
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Tidskriftsartikel (refereegranskat)abstract
- Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10(-8)), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ∼2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.
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| 3. |
- Nikpay, Majid, et al.
(författare)
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A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease
- 2015
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 47:10, s. 1121-1121
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Tidskriftsartikel (refereegranskat)abstract
- Existing knowledge of genetic variants affecting risk of coronary artery disease (CAD) is largely based on genome-wide association study (GWAS) analysis of common SNPs. Leveraging phased haplotypes from the 1000 Genomes Project, we report a GWAS meta-analysis of similar to 185,000 CAD cases and controls, interrogating 6.7 million common (minor allele frequency (MAF) > 0.05) and 2.7 million low-frequency (0.005 < MAF < 0.05) variants. In addition to confirming most known CAD-associated loci, we identified ten new loci (eight additive and two recessive) that contain candidate causal genes newly implicating biological processes in vessel walls. We observed intralocus allelic heterogeneity but little evidence of low-frequency variants with larger effects and no evidence of synthetic association. Our analysis provides a comprehensive survey of the fine genetic architecture of CAD, showing that genetic susceptibility to this common disease is largely determined by common SNPs of small effect size.
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| 4. |
- Abel, I, et al.
(författare)
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Overview of the JET results with the ITER-like wall
- 2013
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Ingår i: Nuclear Fusion. - : IOP Publishing. - 1741-4326 .- 0029-5515. ; 53:10, s. 104002-
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Tidskriftsartikel (refereegranskat)abstract
- Following the completion in May 2011 of the shutdown for the installation of the beryllium wall and the tungsten divertor, the first set of JET campaigns have addressed the investigation of the retention properties and the development of operational scenarios with the new plasma-facing materials. The large reduction in the carbon content (more than a factor ten) led to a much lower Z(eff) (1.2-1.4) during L- and H-mode plasmas, and radiation during the burn-through phase of the plasma initiation with the consequence that breakdown failures are almost absent. Gas balance experiments have shown that the fuel retention rate with the new wall is substantially reduced with respect to the C wall. The re-establishment of the baseline H-mode and hybrid scenarios compatible with the new wall has required an optimization of the control of metallic impurity sources and heat loads. Stable type-I ELMy H-mode regimes with H-98,H-y2 close to 1 and beta(N) similar to 1.6 have been achieved using gas injection. ELM frequency is a key factor for the control of the metallic impurity accumulation. Pedestal temperatures tend to be lower with the new wall, leading to reduced confinement, but nitrogen seeding restores high pedestal temperatures and confinement. Compared with the carbon wall, major disruptions with the new wall show a lower radiated power and a slower current quench. The higher heat loads on Be wall plasma-facing components due to lower radiation made the routine use of massive gas injection for disruption mitigation essential.
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| 5. |
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| 6. |
- Alamaa, Linda, Universitetslektor, biträdande, 1984-, et al.
(författare)
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Why are organisational professionals expanding in the Swedish public sector? The role of accountability
- 2024
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Ingår i: Public Policy and Administration. - London : Sage Publications. - 0952-0767 .- 1749-4192.
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Tidskriftsartikel (refereegranskat)abstract
- Recent research shows that new types of high-skilled administrators, what we in this article label organisational professionals, have amplified their presence in public sector organisations in relation to other types of public sector employees. Our purpose is to analyse how organisational accountability can be seen as a driver behind the expansion of organisational professionals. Intensified political and administrative pressures seem to be driving this process, but there also seems to be internal turfs in which the different parts of the government administration seek to hold each other accountable, a process possibly amplified by professionalising ambitions of the organisational professionals. The article concludes that the bureaucratising effect of accountability demands ought to be highlighted more in critical research of accountability. The study is based on semi-structured interviews and focus groups with public sector professionals in Sweden from different policy sectors and government levels.
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| 7. |
- Andersén, Jimmie, 1981-
(författare)
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Ett politiskt bygge : - översiktsplaneringens innehållsmässiga utveckling
- 2020
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Debate often describes the evolution of spatial planning as a process of neo-liberalisation. However, this evolution has not been studied from the perspective of planning in general in Sweden. Whether comprehensive planning is also undergoing neo-liberalisation is considered here based on these overarching research questions: - To what extent has spatial planning undergone neo-liberalisation?- How can the evolution of comprehensive planning be understood as a neo-liberalisation process?Answering these questions requires an understanding of the content characterising this planning, and of what a neo-liberalisation process entails. To achieve such an understanding, this dissertation examines how planning in general can be understood as both a political control system and a market-based land use regime.The discourse of comprehensive planning was studied by analysing 17 comprehensive plans adopted in five municipalities over the 1989–2014 period.Generally, these plans follow a few main evolutionary paths. Municipal comprehensive planning has transitioned from being instrumental, encountering few problems, to becoming increasingly abstract and all-encompassing. Comprehensive planning increasingly concerns how growth is to be achieved locally. This change is occurring in both form and content. Change in form refers to the fact that comprehensive planning has been encompassing more and more subject areas over time, whereas change in content refers to the increasingly market-based content of such planning.The research question regarding the extent to which spatial planning is undergoing neo-liberalisation is answered by the obvious trend towards neo-liberalisation. This trend is not pervasive, as countervailing tendencies are also present. Spatial planning is thus becoming internally contradictory, with earlier values persisting, albeit often in interaction with new ones.The question of how comprehensive planning can be understood as a neo-liberalisation process has a three-part answer:- As content in comprehensive plans, neo-liberalisation can be understood as a focus on market rationality. - As form in comprehensive plans, neo-liberalisation can be understood as policy production with content that assumes an ever more neo-liberal orientation. Comprehensive planning during the studied period has come to include more and more municipal areas of activity.- From a neo-liberal perspective, neo-liberalisation is understood as economic utility maximisation.Planning is becoming increasingly neo-liberalised, but not neo-liberal. That this has occurred as a result of increasingly comprehensive policy formulations is somewhat surprising. We are faced with the politicisation of planning in general, which is increasingly informed by market-based policy. This trend represents a comprehensive policy shift towards more neo-liberal planning content, accompanied by more policies. More principles are appearing, addressing how planning and development are to proceed compared with the content of pre-existing plans. The neo-liberalisation process is thus occurring via means that are contradictory from a neo-liberal perspective.
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| 8. |
- Andersson Cederholm, Erika, et al.
(författare)
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Performing ambiguous policy : How innovation events simultaneously perform change and collaborative order
- 2020
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Ingår i: Sociological Review. - : Sage Publications. - 0038-0261 .- 1467-954X. ; 68:6, s. 1403-1419
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this article is to analyse how innovation policy is staged and legitimised through the dramatised social process of an event. The context is taken from an annual event, Skåne Innovation Week, which is arranged by the regional innovation system in Skåne, Sweden. Innovation systems often organise similar events internationally, which appear to play a key role in performing inter-organisational collaboration between actors from the public sector, industry and research, as well as manifesting belief in the globalised imaginaries of innovation systems. Through the analytical lens of the event as a social drama, the article examines how the event – and thus, innovation policy – is represented in commemorative films and website documents through which three meeting practices are identified: mingling and hanging out, scripted meeting models and spatial staging. The article argues that these meeting practices and their performed interactive social forms sustain the vagueness and ambiguity inherent in innovation policy, particularly between stability and change. The event can be viewed as a form of performative government that maintains a political order while simultaneously hailing its practices as transformative.
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| 9. |
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| 10. |
- Andersson Cederholm, Erika, et al.
(författare)
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The seduction of an event : Hospitality in the regional innovation system
- 2019
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Ingår i: Fika, Hygge and Hospitality : The Cultural Complexity of Service Organisation in the Öresund Region - The Cultural Complexity of Service Organisation in the Öresund Region. - 9789170613029 ; :39, s. 131-150
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Bokkapitel (refereegranskat)
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