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| 2. |
- Carlsson, Rose-Marie, et al.
(författare)
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Two consecutive randomized controlled pertussis booster trials in children initially vaccinated in infancy with an acellular vaccine: The first with a five-component Tdap vaccine to 5-year olds and the second with five- or monocomponent Tdap vaccines at age 14-15 years
- 2015
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Ingår i: Vaccine. - : Elsevier BV. - 0264-410X .- 1873-2518. ; 33:31, s. 3717-3725
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Tidskriftsartikel (refereegranskat)abstract
- Prior study children from a DTaP efficacy trial were recruited at ages 5 and 15 years to randomized booster trials addressing immunogenicity and reactogenicity; 475 preschool children received mixed or separate injections of a reduced antigen vaccine (Tdap5, Sanofi Pasteur MSD) and an inactivated polio vaccine, and 230 adolescents received the same or another booster vaccine (Tdap1, SSI, Denmark). Pre-vaccination antibody concentrations against pertussis antigens were significantly higher at 15 than 5 years of age, probably due to natural boosting between the studies. Tdap5 induced comparable anti-PT concentrations at both ages, but antibody responses were significantly higher to filamentous haemagglutinin, pertactin and fimbriae 2/3 in adolescents. As expected, a higher amount of PT (Tdap1, 20 mu g) induced a stronger anti-PT response than a lower amount (Tdap5, 2.5 mu g). The frequency of adverse events was low and there were no serious adverse reactions. All local reactions had an early onset and a short duration. A large swelling or redness of more than half of the upper arm circumference was reported in 8/475 5-year-olds and in 6/230 15-year-olds. Children vaccinated with Tdap5 reported more moderate pain in adolescence than at preschool age, whereas itching was only reported in preschool children. Sweden introduced DTaP vaccines in 1996 after a 17-year hiatus with no general pertussis vaccination and pertussis was still endemic at the time of the studies. The frequency of adverse events was nevertheless low in both preschool children and adolescents and antibody responses were adequate. These studies document immunogenicity and reactogenicity in a trial cohort consecutively vaccinated with acellular pertussis vaccines from infancy to adolescence. (C) 2015 Elsevier Ltd. All rights reserved.
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| 4. |
- Franciscangelis, C., et al.
(författare)
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Vibration measurement on composite material with embedded optical fiber based on phase-OTDR
- 2017
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Ingår i: Proceedings of SPIE - The International Society for Optical Engineering Volume 10168, Sensors and Smart Structures Technologies for Civil, Mechanical, and Aerospace Systems 2017; 101683Q (2017). - : SPIE. - 9781510608214
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Konferensbidrag (refereegranskat)abstract
- Distributed sensors based on phase-optical time-domain reflectometry (phase-OTDR) are suitable for aircraft health monitoring due to electromagnetic interference immunity, small dimensions, low weight and flexibility. These features allow the fiber embedment into aircraft structures in a nearly non-intrusive way to measure vibrations along its length. The capability of measuring vibrations on avionics structures is of interest for what concerns the study of material fatigue or the occurrence of undesirable phenomena like flutter. In this work, we employed the phase-OTDR technique to measure vibrations ranging from some dozens of Hz to kHz in two layers of composite material board with embedded polyimide coating 0.24 numerical aperture single-mode optical fiber. © 2017 SPIE.
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| 6. |
- Hallander, H, et al.
(författare)
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[New pertussis vaccines are tested].
- 1992
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Ingår i: Läkartidningen. - 0023-7205 .- 1652-7518. ; 89:45, s. 3820-2, 3825
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Tidskriftsartikel (refereegranskat)
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| 7. |
- Hallander, P., et al.
(författare)
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Forming induced wrinkling of composite laminates with mixed ply material properties; an experimental study
- 2015
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Ingår i: Composites. Part A, Applied science and manufacturing. - : Elsevier BV. - 1359-835X .- 1878-5840. ; 78, s. 234-245
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Tidskriftsartikel (refereegranskat)abstract
- One disadvantage of multi-layer forming of unidirectional (UD) prepreg tape is the risk of out-of-plane wrinkling. This study aims to show how mixed ply material properties affect global wrinkling behaviour. An experimental study was performed using pre-stacked UD prepreg on a forming tool with varying cross sections. Parameters studied include local interply friction, effects of co-stacking and fibre stresses in critical fibre directions. Experimental evaluation was performed on out-of-plane defect height, type and location. The study shows that fibre stresses in some fibre directions were crucial for the shearing required to avoid wrinkling. The same fibre stresses may cause wrinkling if the lamina is stacked in a non-beneficial order. Changing the friction locally, or reducing the number of difficult combinations of fibre angles, improves the forming outcome slightly. However, in order to make a significant improvement, co-stacking or different fibre stacking is required.
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| 8. |
- Hallander, P., et al.
(författare)
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Interface manipulation towards wrinkle-free forming of stacked UD prepreg layers
- 2016
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Ingår i: Composites. Part A, Applied science and manufacturing. - : Elsevier. - 1359-835X .- 1878-5840. ; 90, s. 340-348
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this paper is to experimentally study how forming behaviour can be changed by local manipulation of prepreg interfacial characteristics. Different methods for surface modification are examined, however all were aimed at enabling significantly increased interply friction. The paper shows that by using increased friction in between layers, these neighbouring pairs will act together during forming, thereby either improving or exacerbating the forming outcome. For the geometry utilized, wrinkle free forming was obtained when the cross-plied layers were paired to deform mainly through intraply shear during forming. The method is supported by the appended numerical analysis and interaction between forming mechanisms and radius thinning is instigated as part of the experimental outcome.
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