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- Bousquet, J, et al.
(författare)
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Nrf2-interacting nutrients and COVID-19: time for research to develop adaptation strategies
- 2020
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Ingår i: Clinical and translational allergy. - : Wiley. - 2045-7022. ; 10:1, s. 58-
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Tidskriftsartikel (refereegranskat)abstract
- There are large between- and within-country variations in COVID-19 death rates. Some very low death rate settings such as Eastern Asia, Central Europe, the Balkans and Africa have a common feature of eating large quantities of fermented foods whose intake is associated with the activation of the Nrf2 (Nuclear factor (erythroid-derived 2)-like 2) anti-oxidant transcription factor. There are many Nrf2-interacting nutrients (berberine, curcumin, epigallocatechin gallate, genistein, quercetin, resveratrol, sulforaphane) that all act similarly to reduce insulin resistance, endothelial damage, lung injury and cytokine storm. They also act on the same mechanisms (mTOR: Mammalian target of rapamycin, PPARγ:Peroxisome proliferator-activated receptor, NFκB: Nuclear factor kappa B, ERK: Extracellular signal-regulated kinases and eIF2α:Elongation initiation factor 2α). They may as a result be important in mitigating the severity of COVID-19, acting through the endoplasmic reticulum stress or ACE-Angiotensin-II-AT1R axis (AT1R) pathway. Many Nrf2-interacting nutrients are also interacting with TRPA1 and/or TRPV1. Interestingly, geographical areas with very low COVID-19 mortality are those with the lowest prevalence of obesity (Sub-Saharan Africa and Asia). It is tempting to propose that Nrf2-interacting foods and nutrients can re-balance insulin resistance and have a significant effect on COVID-19 severity. It is therefore possible that the intake of these foods may restore an optimal natural balance for the Nrf2 pathway and may be of interest in the mitigation of COVID-19 severity.
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- Glaa, Besma, 1978-, et al.
(författare)
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Modeling the emergency path handling and emergency department simulation
- 2006
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Ingår i: 2006 IEEE International Conference on Systems, Man and Cybernetics. - : IEEE conference proceedings. - 1424400996 ; , s. 4585-4590
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Konferensbidrag (refereegranskat)abstract
- The emergency department in a hospital, as its name implies, is a facility to be utilized by those who require emergency medical care. This paper introduces the longitudinal organization of the patient handling called "emergency path" and it discusses the application of the company modelling methods especially the GRAI methodology in the emergency department. The goal is to optimize these paths and to improve the quality of the patient handling while mastering the costs. The development of this model was based on the ED and three geriatrics, neurology and traumatology services. Simulation was used in this paper to assess the effects of some changes at the ED of the Medical Center of Valenciennes in France. Our survey is integrated into the regional project whose theme are the emergency paths that have just been created at the ED of Valenciennes Hospital center and will contribute to the ED service project achievement.
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| 7. |
- Ibragimov, Nail H., et al.
(författare)
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Introduction to differential equations
- 2006
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Bok (övrigt vetenskapligt/konstnärligt)abstract
- This book is based on lectures in differential equations delivered by the authors, namely, by A. Al-Hammadi at the University of Bahrain and by N. Ibragimov at the Blekinge Institute of Technology, Sweden. It is designed for a one semester course in differential equations. We assume that the reader has taken standard courses in mathematical analysis and has encountered basic concepts from linear algebra such as vectors, matrices and algebraic linear systems. Our aim is to provide students with an easy to follow introduction to the subject containing classical devices enriched by fundamentals of Lie group methods given in Chapter 9.
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| 8. |
- Saidas Nair, K, et al.
(författare)
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Alteration of the serine protease PRSS56 causes angle-closure glaucoma in mice and posterior microphthalmia in humans and mice
- 2011
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Ingår i: NATURE GENETICS. - : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 43:6, s. 579-U118
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Tidskriftsartikel (refereegranskat)abstract
- Angle-closure glaucoma (ACG) is a subset of glaucoma affecting 16 million people(1-3). Although 4 million people are bilaterally blind from ACG(4,5), the causative molecular mechanisms of ACG remain to be defined. High intraocular pressure induces glaucoma in ACG. High intraocular pressure traditionally was suggested to result from the iris blocking or closing the angle of the eye, thereby limiting aqueous humor drainage. Eyes from individuals with ACG often have a modestly decreased axial length, shallow anterior chamber and relatively large lens, features that predispose to angle closure(6). Here we show that genetic alteration of a previously unidentified serine protease (PRSS56) alters axial length and causes a mouse phenotype resembling ACG. Mutations affecting this protease also cause a severe decrease of axial length in individuals with posterior microphthalmia. Together, these data suggest that alterations of this serine protease may contribute to a spectrum of human ocular conditions including reduced ocular size and ACG.
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