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- Af Winklerfelt Hammarberg, Sandra, et al.
(författare)
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Outcomes of psychiatric interviews and self-rated symptom scales in people on sick leave for common mental disorders: an observational study.
- 2022
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Ingår i: BMJ open. - : BMJ. - 2044-6055. ; 12:6
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Tidskriftsartikel (refereegranskat)abstract
- To investigate the correspondence between diagnoses on sick leave certificates and diagnoses made in structured psychiatric interviews. Secondary aims were to investigate length of sick leave by diagnoses on sick leave certificates, diagnoses made in structured interviews and symptom severity.Observational study consisting of a secondary analysis of data from a randomised controlled trial and an observational study.The regions of Stockholm and Västra Götaland, Sweden.480 people on sick leave for common mental disorders.Participants were examined with structured psychiatric interviews and self-rated symptom severity scales.(1) Sick leave certificate diagnoses, (2) diagnoses from the Mini International Neuropsychiatric Interview and the Self-rated Stress-Induced Exhaustion Disorder (SED) Instrument (s-ED), (3) symptom severity (Montgomery-Asberg Depression Rating Scale-self-rating version and the Karolinska Exhaustion Disorder Scale) and (4) number of sick leave days.There was little correspondence between diagnoses on sick leave certificates and diagnoses made in structured psychiatric interviews. Many participants on sick leave for SED, anxiety disorder or depression fulfilled criteria for other mental disorders. Most on sick leave for SED (76%) and anxiety disorder (67%) had depression (p=0.041). Length of sick leave did not differ by certificate diagnoses. Participants with SED (s-ED) had longer sick leave than participants without SED (144 vs 84 days; 1.72 (1.37-2.16); p<0.001). More severe symptoms were associated with longer sick leave.Diagnoses on sick leave certificates did not reflect the complex and overlapping nature of the diagnoses found in the structured psychiatric interviews. This finding is relevant to the interpretation of information from health data registers, including studies and guidelines based on these data. A result of clinical interest was that more severe symptoms predicted long-term sick leave better than actual diagnoses.
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| 2. |
- Azevedo, Carla, et al.
(författare)
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Parkinsons disease and multiple system atrophy patient iPSC-derived oligodendrocytes exhibit alpha-synuclein-induced changes in maturation and immune reactive properties
- 2022
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Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 119:12
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Tidskriftsartikel (refereegranskat)abstract
- Limited evidence has shed light on how aSYN proteins affect the oligodendrocyte phenotype and pathogenesis in synucleinopathies that include Parkinsons disease (PD) and multiple system atrophy (MSA). Here, we investigated early transcriptomic changes within PD and MSA O4(+) oligodendrocyte lineage cells (OLCs) generated from patient-induced pluripotent stem cells (iPSCs). We found impaired maturation of PD and MSA O4(+) OLCs compared to controls. This phenotype was associated with changes in the human leukocyte antigen (HLA) genes, the immunoproteasome subunit PSMB9, and the complement component C4b for aSYN p.A53T and MSA O4(+) OLCs, but not in SNCA(trip) O4(+) OLCs despite high levels of aSYN assembly formation. Moreover, SNCA overexpression resulted in the development of O4(+) OLCs, whereas exogenous treatment with aSYN species led to significant toxicity. Notably, transcriptome profiling of genes encoding proteins forming Lewy bodies and glial cytoplasmic inclusions revealed clustering of PD aSYN p.A53T O4(+) OLCs with MSA O4(+) OLCs. Our work identifies early phenotypic and pathogenic changes within human PD and MSA O4(+) OLCs.
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| 3. |
- Hammarberg, Christina, et al.
(författare)
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Independent and effective care – district nurses’ experiences of prescribing drugs : A systematic qualitative literature review
- 2024
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Ingår i: Nordic journal of nursing research. - : Sage Publications. - 2057-1585 .- 2057-1593. ; 44
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Forskningsöversikt (refereegranskat)abstract
- Numerous countries in the world have chosen to allow district nurses to prescribe drugs to streamline the primary care process. This qualitative, systematic literature study aimed to examine district nurses’ experience of prescribing within primary care. The search followed the PRISMA-P search strategy, and the quality assessment of the nine articles was completed using the review template for assessing studies with qualitative methodology, using GRADE CERQual. The databases CINAHL, Pubmed, PsycINFO, and Scopus were used. The result shows that district nurses experience prescribing as crucial for being able to meet patient needs through holistic and person-centered care. Being able to sufficiently and efficiently meet patient needs contributed to increased job satisfaction and professional pride in district nurses. However, district nurses need more collegial support and training in prescribing. The additional burden that the ability to prescribe poses needs to be addressed to prevent limitations in the prescription rights of district nurses. Through an extended prescription right, district nurses can contribute to a more efficient care system that can meet future demand for healthcare services in primary care.
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| 7. |
- Bäckman, Kerstin, 1956-, et al.
(författare)
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Preschool teachers and their professional knowledge : teaching mathematics in preschool
- 2015
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Ingår i: 25th EECERA Annual conference 'Innovation, experimentation and adventure in early childhood' : Abstract Book. ; , s. 272-272
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Konferensbidrag (refereegranskat)abstract
- The aim of this paper is to discuss the knowledge preschool teachers need when they teach mathematics. The study focuses on how the knowledge from curriculum affect and is transmitted to teaching and how content is selected, valued and organised when they work with mathematics and documentation. Earlier research shows that the official curricula are important and have impact on how teachers organise the practice (Carr, 2007; Clements & Sarama, 2007). This paper is discussing preschool teacher’s professional knowledge in relation to mathematics and documentation and curriculum. Curriculum theory is used as frame factor in the analysis (Dahlberg et al., 2005; Lundgren, 1972; National Agency, 2010 & 2012). The empirical data drawn from a larger study in Sweden (Bäckman, 2015) include interviews with 19 Swedish preschool teachers. Focus was on their understanding of knowledge and strategies in teaching mathematics. Analyses also consist of frame factors like policy documents and the national preschool curriculum. The ethical considerations follow the rules from The Swedish Research Council (2011). The main findings of the analyses concerning preschool teachers' professional knowledge in relation to teaching mathematics are that policy documents and the national curriculum are strong frame factors and also support different educational strategies. The teachers want to design learning environments that supports children’s mathematical exploring and learning. In that work they used documentation as a strategy to organise the teaching. Children’s teachers need knowledge of the frame factors, both international and national, when they create participatory practice and learning opportunities for children.
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| 8. |
- Djelloul, Mehdi, et al.
(författare)
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Reporting on methods to generate and purify rodent and human oligodendrocytes from different sources
- 2017
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Ingår i: Stem Cell Research. - : Elsevier BV. - 1873-5061. ; 20, s. 58-66
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Tidskriftsartikel (refereegranskat)abstract
- Oligodendrocytes are part of the glial cells located in the central nervous system, capable of providing trophic support to neurons and ensheathing their axons. These cells can become dysfunctional under pathologic condition. Rodent and human pluripotent stem cells are inexhaustible sources for producing oligodendrocytes that can be used for disease modeling and cell replacement therapy studies. They also offer many opportunities to model the contribution of oligodendrocytes in non-genetic disorders such as multiple system atrophy. In this method article, we provide robust and reproducible differentiation protocols to obtain oligodendrocyte progenitor cells and purify them using fluorescence activated cell sorting.
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| 9. |
- Fagerlönn, Johan, et al.
(författare)
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Designing a multimodal warning display for an industrial control room
- 2017
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Ingår i: ACM International Conference Proceeding Series. - New York, NY, USA : ACM. - 9781450353731
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Konferensbidrag (refereegranskat)abstract
- This paper presents the development of a multimodal warning display for a paper mill control room. In previous work, an informative auditory display for control room warnings was proposed. The proposed auditory solution conveys information about urgent events by using a combination of auditory icons and tonal components. The main aim of the present study was to investigate if a complementary visual display could increase the effectiveness and acceptance of the existing auditory solution. The visual display was designed in a user-driven design process with operators. An evaluation was conducted both before and after the implementation. Subjective ratings showed that operators found it easier to identify the alarming section using the multimodal display. These results can be useful for any designer intending to implement a multimodal display for warnings in an industrial context. © 2017 Copyright is held by the owner/author(s).
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| 10. |
- Falk, Malin Värmå, et al.
(författare)
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A qualitative study of facilitators and barriers to participate in a needle exchange program for women who inject drugs
- 2020
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Ingår i: Harm Reduction Journal. - : BMC. - 1477-7517. ; 17:1
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Tidskriftsartikel (refereegranskat)abstract
- Background Women who inject drugs (WWID) show higher levels of injecting risk behaviour compared to men, putting them at risk of contracting HIV and hepatitis C (HCV). Compared to men, WWID are also less present in harm reduction programs such as needle exchange programs (NEP). The aim of this study is to investigate reasons for, and barriers to, participation in NEP among WWID in Sweden, and to identify measures that could be taken to strengthen the program and increase participation among WWID. Method In-depth interviews (IDIs) were conducted with 20 WWID who had participated in the Stockholm NEP for at least six months and was over 18 years old. IDIs were audio recorded and transcribedet verbatim. Qualitative content analysis was used to identify themes. Results The need for sterile injection equipment was identified as the main driver to join and remain in the NEP program. Continuous participation in the NEP was further driven by easy access to a multitude of health-related services. The most valued service was the sexual and reproductive health services (SRHR), allowing participants to access contraceptives, cervical cancer screening and sexually transmitted infections testing (STI-testing). NEP staffs' respectful treatment of participants further contributed to program participation. However, participants also expressed a number of concerns around NEP participation, which created barriers to joining. These included losing custody or visitation rights to children, male partner jealousy and violence, unwillingness to spend time in the waiting area and fear of receiving positive HIV/HCV test results. Practical barriers included limited opening hours and travel distance to the NEP. To strengthen the program, most participants requested additional SRHR services. Most participants also proposed some form of "women only" access to the NEP, to strengthen the feeling of the NEP as a safe space. Conclusion This study identified factors that may increase uptake of NEP among WWID. Additional SRHR services and "women only" access are recommended to be implemented and evaluated as part of NEP. These findings may inform and improve the current scale-up of NEPs in Sweden to ensure equal access to services.
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