| 1. |
- Björk, Ann-Kristin, et al.
(författare)
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Occupational allergic contact dermatitis to gloves, follow-up of investigated patients
- 2014
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Ingår i: Contact Dermatitis. - : Wiley. - 0105-1873. ; 70:Suppl s1, s. 94-94
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Background: In the Department of Occupational and Environmental Dermatology there has been an increase in the inflow of patients, working as surgical nurses or surgeons. They have been referred due to presumed occupational contact dermatitis. Results from investigated patients have in part been presented previously, where the investigation has shownmultiple contact allergies caused by their occupational use of gloves. Allergens such as diphenylguanidine were found in the gloves and contact allergies to their rubber gloves were found. Many of the patients have been working for decades in their present occupation, but the hand dermatitis had often been present for less than a year. Objectives: To present a follow-up of patientswith hand dermatitis due to gloves. Methods: A follow-up of the patients and a structure for the investigation of the individual patient are given. Results: The cases will be presented with their contact allergies, howtheinvestigation isperformedandtheoutcomeof theprevention by avoiding gloves containing the allergens diagnosed in the individual patients. Conclusions: For health care personnel hand hygiene and the wearing of protective gloves are mandatory. Our findings indicate that the increased need to use rubber gloves and at the same time the exclusion of latex gloves give rise to new contact allergies which are clinically relevant. In the investigation, and the advice given to the patients, several factors have to be taken into consideration, including the fast change of glove material. The cases indicate the importance of close cooperation between chemists and dermatologists and the possibility to perform chemical analysis. Furthermore, and just as important for this patient group, is that with correct diagnosis and advice the contact dermatitis can actually heal completely and the patients continue in their work.
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| 2. |
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| 3. |
- Brynolf, Andreas, et al.
(författare)
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Contact allergy investigations in healthcare workers with face mask-related skin disease
- 2023
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Ingår i: Contact Dermatitis. - 0105-1873. ; 89:1, s. 16-19
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Tidskriftsartikel (refereegranskat)abstract
- Background: During the COVID-19 pandemic, the use of face masks has increased among healthcare workers (HCWs). Questionnaire studies have shown a high frequency of self-reported facial adverse skin reactions. Case reports have been published on face mask-induced allergic contact dermatitis and urticaria. Objectives: To describe the results of the contact allergy investigations in consecutive HCWs investigated for skin reactions to face masks during the COVID-19 pandemic and the results of the chemical investigations of face masks supplied by the hospital. Methods: Participants were patch tested with baseline series and chemicals previously reported in face masks not included in the baseline series. Face mask(s) brought by the HCW were tested as is and/or in acetone extract. Chemical analyses were performed on nine different face masks for potential allergens. Results: Fifty-eight HCWs were investigated. No contact allergies were found to the face mask(s) tested. Eczema was the most common type of skin reaction, followed by an acneiform reaction. Colophonium-related substances were found in one respirator and 2,6-di-t-butyl-4-methylphenol (BHT) were found in two respirators. Conclusion: Based on this report, contact allergies to face masks is uncommon. Patch test with colophonium-related substances and BHT should be considered when investigating adverse skin reactions to face masks.
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| 4. |
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| 5. |
- Enberg, Johanna, et al.
(författare)
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The use of carvone in consecutive patch testing
- 2023
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Ingår i: Contact Dermatitis. - : John Wiley & Sons. - 0105-1873 .- 1600-0536. ; 88:3, s. 206-211
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Carvone (l-carvone) is a mint-tasting flavour additive that most of us is exposed to and can cause allergic contact reactions.OBJECTIVES: To analyse the frequency and the relevance of positive carvone reactions in a dermatitis population.METHOD: A retrospective analysis of dermatitis patients consecutively tested with carvone from 2017 to 2021. Data were retrieved from the department's patch-test database.RESULTS: Of 3554 patients tested with carvone, 28 (0.79%) had a positive reaction. Carvone-positive patients had higher mean age, were significantly more likely female (p < 0.001) and had often an intraoral/lip involvement (p < 0.001). In the carvone-positive group, 50% (n = 14) had a relevant reaction, and in 4 of 14, the relevance was first revealed after test reading. Of the carvone-positive patients, 18 of 28 did not have a coexisting allergy to a fragrance/flavour allergen and of these 44% had a relevant allergy.CONCLUSIONS: The study suggests that a significant fraction of relevant carvone contact allergies may be overlooked if the allergen is not tested. Furthermore, as the exposure is widespread, inclusion of carvone in the Swedish baseline series may be justified even if the contact allergy prevalence is below 1%.
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| 6. |
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| 7. |
- Hamnerius, Nils, et al.
(författare)
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Colophonium-related Allergic Contact Dermatitis Caused by Medical Adhesive Tape Used to Prevent Skin Lesions in Soldiers
- 2023
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Ingår i: Acta Dermato-Venereologica. - 0001-5555. ; 103
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Tidskriftsartikel (refereegranskat)abstract
- Medical adhesive tapes are commonly recommended for the prevention of friction blisters during hiking and military marches. The aim of this paper is to report on the results of investigations into an outbreak of taperelated foot dermatitis in 26 military conscripts following continuous use of medical adhesive tapes for several days during a field exercise. Patch tests were performed using baseline series and aimed testing was performed with colophonium-related substances and different medical adhesive tapes. Contact allergy to the adhesive tapes used was found in 20 (77%) subjects, and contact allergy to colophonium in 16 (61%). Chemical analysis detected colophonium-related substances in the culprit tapes. Compared with consecutive dermatitis patients investigated at our Department of Occupational and Environmental Dermatology in the previous 10 years, conscripts with colophonium allergy had increased odds ratios for concomitant contact allergy to phenol formaldehyde resins and fragrance substances including hydroperoxides of limonene and linalool. The results show that prolonged use of medical adhesive tapes on intact skin carries a high risk for allergic contact dermatitis. Prior to their introduction on the market, medical devices should be assessed for possible side-effects.
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| 8. |
- Hamnerius, Nils, et al.
(författare)
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Factors influencing the skin exposure to diphenylguanidine in surgical gloves
- 2014
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Ingår i: Contact Dermatitis. - : Wiley. - 0105-1873. ; 70:Suppl s1, s. 59-60
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Background: For health care personnelhandhygieneandwearing appropriate protective gloves are compulsory. We have noticed an increase of hand eczema caused by contact allergy from rubber chemicals such as diphenylguanidine (DPG) in synthetic rubber gloves used by surgeons and surgical nurses. The exposure time to surgical gloves as well as the number of gloves used per day vary. Furthermore surgery very often includes the use of skin disinfectants before glove donning. Objectives: Does the exposure time influence the amount of DPG released from the gloves? Does the exposure of skin disinfectants before glove donning influence the release of DPG? Methods: Using synthetic sweat, the amount of DPG released from the inside of the gloves at different timeswas measured by HPLC. The remaining extractable DPG was estimated by washing the inside of the gloves with ethanol (50% in water) for 10min. The amount of DPG found on the hands exposed to 3ml skin disinfectant allowed to dry prior to glove donning was compared to the amount found on unexposed hands. After wearing gloves for 60 min the handswerewashedwith ethanol and the amount of DPG recovered was analysed with HPLC. Results: After 10, 30, 60 and 180 min approximately 73%, 79%, 82%, 87% of the total amount of DPG was released. For all comparisons the amount of DPG released was higher on the hand exposed to disinfectants compared with the unexposed hand. Conclusions: A comparatively short exposure time to gloves (10min) implies a substantial exposure to DPG. Thus, repeated usage of glovesmight enhance skin exposure to this rubber chemical. Skin disinfectants does increase the amount of DPG released from the gloves. Thus, possibly the components of the disinfectant remaining on the skin or some othermechanism add to the exposure to DPG.
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| 9. |
- Hamnerius, Nils, et al.
(författare)
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Fast and Standardized Skin Grafting of Leg Wounds With a New Technique : Report of 2 Cases and Review of Previous Methods
- 2016
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Ingår i: Eplasty: Open Access Journal of Plastic and Reconstructive Surgery. - 1937-5719. ; 16
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Forskningsöversikt (refereegranskat)abstract
- BACKGROUND: Chronic leg ulcers remain a challenge to the treating physician. Such wounds often need skin grafts to heal. This necessitates a readily available, fast, simple, and standardized procedure for grafting.OBJECTIVES: The aim of this work was to test a novel method developed for outpatient transplant procedures.METHODS: The procedure employs a handheld disposable dermatome and a roller mincer that cut the skin into standardized micrografts that can be spread out onto a suitable graft bed. Wounds were followed until healed and photographed.RESULTS: The device was successfully used to treat and close a traumatic lower limb wound and a persistent chronic venous leg ulcer. The donor site itself healed by secondary intent with minimal cosmetic impairment.CONCLUSION: The method was successfully used to graft 2 lower extremity wounds.
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