| 1. |
- Allentoft, Morten E., et al.
(författare)
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Population genomics of post-glacial western Eurasia
- 2024
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Ingår i: Nature. - 0028-0836 .- 1476-4687. ; 625:7994, s. 301-311
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Tidskriftsartikel (refereegranskat)abstract
- Western Eurasia witnessed several large-scale human migrations during the Holocene1–5. Here, to investigate the cross-continental effects of these migrations, we shotgun-sequenced 317 genomes—mainly from the Mesolithic and Neolithic periods—from across northern and western Eurasia. These were imputed alongside published data to obtain diploid genotypes from more than 1,600 ancient humans. Our analyses revealed a ‘great divide’ genomic boundary extending from the Black Sea to the Baltic. Mesolithic hunter-gatherers were highly genetically differentiated east and west of this zone, and the effect of the neolithization was equally disparate. Large-scale ancestry shifts occurred in the west as farming was introduced, including near-total replacement of hunter-gatherers in many areas, whereas no substantial ancestry shifts happened east of the zone during the same period. Similarly, relatedness decreased in the west from the Neolithic transition onwards, whereas, east of the Urals, relatedness remained high until around 4,000 bp, consistent with the persistence of localized groups of hunter-gatherers. The boundary dissolved when Yamnaya-related ancestry spread across western Eurasia around 5,000 bp, resulting in a second major turnover that reached most parts of Europe within a 1,000-year span. The genetic origin and fate of the Yamnaya have remained elusive, but we show that hunter-gatherers from the Middle Don region contributed ancestry to them. Yamnaya groups later admixed with individuals associated with the Globular Amphora culture before expanding into Europe. Similar turnovers occurred in western Siberia, where we report new genomic data from a ‘Neolithic steppe’ cline spanning the Siberian forest steppe to Lake Baikal. These prehistoric migrations had profound and lasting effects on the genetic diversity of Eurasian populations.
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| 2. |
- Ölvander, Johan, et al.
(författare)
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Preface
- 2018
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Ingår i: Proceedings of NordDesign: Design in the Era of Digitalization, NordDesign 2018.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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| 3. |
- Allentoft, Morten E., et al.
(författare)
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100 ancient genomes show repeated population turnovers in Neolithic Denmark
- 2024
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Ingår i: Nature. - 0028-0836 .- 1476-4687. ; 625, s. 329-337
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Tidskriftsartikel (refereegranskat)abstract
- Major migration events in Holocene Eurasia have been characterized genetically at broad regional scales1–4. However, insights into the population dynamics in the contact zones are hampered by a lack of ancient genomic data sampled at high spatiotemporal resolution5–7. Here, to address this, we analysed shotgun-sequenced genomes from 100 skeletons spanning 7,300 years of the Mesolithic period, Neolithic period and Early Bronze Age in Denmark and integrated these with proxies for diet (13C and 15N content), mobility (87Sr/86Sr ratio) and vegetation cover (pollen). We observe that Danish Mesolithic individuals of the Maglemose, Kongemose and Ertebølle cultures form a distinct genetic cluster related to other Western European hunter-gatherers. Despite shifts in material culture they displayed genetic homogeneity from around 10,500 to 5,900 calibrated years before present, when Neolithic farmers with Anatolian-derived ancestry arrived. Although the Neolithic transition was delayed by more than a millennium relative to Central Europe, it was very abrupt and resulted in a population turnover with limited genetic contribution from local hunter-gatherers. The succeeding Neolithic population, associated with the Funnel Beaker culture, persisted for only about 1,000 years before immigrants with eastern Steppe-derived ancestry arrived. This second and equally rapid population replacement gave rise to the Single Grave culture with an ancestry profile more similar to present-day Danes. In our multiproxy dataset, these major demographic events are manifested as parallel shifts in genotype, phenotype, diet and land use.
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| 4. |
- Amann, Daniel, 1967-
(författare)
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Exploring affordability in concept generation for complex defence products
- 2022
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- National defence budgets face pressure from intergenerational escalating costs for complex defence products, such as fighter aircraft and submarines. These escalating costs originate from ever-increasing performance requirements due to the competitive nature of warfare. In combat, only winning is good enough. Therefore, the products’ performance is considered crucial for gaining an edge over an opponent. As the continuous development of ever-costlier complex defence products is not sustainable, it is high time for a path change towards affordability, meaning less costly products without any compromises in terms of operational requirements. However, the fact that this cost escalation has long been recognised as unsustainable indicates that a path change towards affordability will not be easy to achieve. Such a path change will likely require radical changes in product concepts – even though costs might be reduced in other ways, product concepts are believed to have the greatest potential. In accordance with this assumption, this thesis suggest that the phenomenon of continuous generation of ever-costlier complex defence concepts is ultimately sealed in the front end of innovation, where opportunities are identified and product concepts are defined. Accordingly, this thesis aims to explore how firms and customers can influence activities in the front end of innovation in order to successfully manage the affordability of complex defence products. This aim is approached through phenomenon-driven research performed in a set of four concatenated studies, represented by five papers. By letting successive studies be informed by preceding studies, new knowledge and theory are added to this under-researched topic. Empirically, several factors and aspects influencing the front end of innovation are identified as potential barriers to or enablers of path changes towards affordability. In addition, different measures that companies and customers can adopt to support such path changes are proposed. The thesis contributes to extant theory by providing a definition of affordability adapted to complex defence products, and by contrasting affordability with established concepts and methods aimed at making products less costly. Furthermore, benefits and deficiencies in the industry’s handling of concept generation for complex defence products are highlighted from an affordability perspective, and the influence of specific characteristics on path changes towards affordability in relation to complex defence equipment is described and discussed. Finally, conditions supporting affordability related to opportunities, knowledge and motivations are described, and the benefits of providing those generating complex capability-oriented concepts with cost-related information are demonstrated.In addition to these contributions to theory, this thesis has several implications for the practice of companies and governmental customers. It highlights measures that these two sets of actors can take to shape conditions and, thereby, influence key activities in the front end of innovation to generate complex defence-product concepts that meet affordability criteria. These suggested measures constitute an embryo of an explicit approach to affordability management.
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| 5. |
- Dalbøge, Annett, et al.
(författare)
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Upper arm elevation and repetitive shoulder movements : A general population job exposure matrix based on expert ratings and technical measurements
- 2016
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Ingår i: Occupational and Environmental Medicine. - : BMJ. - 1351-0711 .- 1470-7926. ; 73:8, s. 553-560
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Tidskriftsartikel (refereegranskat)abstract
- Objectives We recently constructed a general population job exposure matrix (JEM), The Shoulder JEM, based on expert ratings. The overall aim of this study was to convert expert-rated job exposures for upper arm elevation and repetitive shoulder movements to measurement scales. Methods The Shoulder JEM covers all Danish occupational titles, divided into 172 job groups. For 36 of these job groups, we obtained technical measurements (inclinometry) of upper arm elevation and repetitive shoulder movements. To validate the expert-rated job exposures against the measured job exposures, we used Spearman rank correlations and the explained variance according to linear regression analyses (36 job groups). We used the linear regression equations to convert the expert-rated job exposures for all 172 job groups into predicted measured job exposures. Bland-Altman analyses were used to assess the agreement between the predicted and measured job exposures. Results The Spearman rank correlations were 0.63 for upper arm elevation and 0.64 for repetitive shoulder movements. The expert-rated job exposures explained 64% and 41% of the variance of the measured job exposures, respectively. The corresponding calibration equations were y=0.5%time+0.16×expert rating and y=27°/s+0.47×expert rating. The mean differences between predicted and measured job exposures were zero due to calibration; the 95% limits of agreement were ±2.9% time for upper arm elevation >90° and ±33°/s for repetitive shoulder movements. Conclusions The updated Shoulder JEM can be used to present exposure-response relationships on measurement scales.
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| 6. |
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| 7. |
- Fich, Lars Brorson, et al.
(författare)
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Can architectural design alter the physiological reaction to psychosocial stress? : a virtual TSST experiment
- 2014
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Ingår i: Physiology and Behavior. - 0031-9384 .- 1873-507X. ; 135, s. 91-97
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Tidskriftsartikel (refereegranskat)abstract
- It has long been established, that views to natural scenes can a have a dampening effect on physiological stress responses. However, as people in Europe, Canada and North America today spent 50-85% of their time indoors, attention might also be paid to how the artificial man-made indoor environment influences these mechanisms. The question that this study attempts to start addressing is therefore whether certain design, characteristics of indoor spaces can make a difference to the physiological stress response as well. Using a virtual version of the Trier Social Stress Test, in which the space is computer generated and properties of the space therefore can be systematically varied, we measured saliva cortisol and heart rate variability in participants in a closed room versus a room with openings. As shown by a significant linear contrast interaction between groups and TSST conditions, participants in the closed room responded with more pronounced cortisol reactivity to stress induction, and continued to show higher levels throughout recovery, compared to participants in the open room. No differences were found regarding any part of the autonomic nervous system.
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| 8. |
- Fich, Lars Brorson, et al.
(författare)
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Can architectural design alter the physiological reaction to psychosocial stress? A virtual TSST experiment.
- 2014
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Ingår i: Physiology & Behavior. - : Elsevier BV. - 1873-507X .- 0031-9384. ; 135, s. 91-97
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Tidskriftsartikel (refereegranskat)abstract
- Is has long been established, that views to natural scenes can a have a dampening effect on physiological stress responses. However, as people in Europe, Canada and North America today spent 50-85% of their time indoors, attention might also be paid to how the artificial man-made indoor environment influences these mechanisms. The question that this study attempts to start addressing is therefore whether certain design, characteristics of indoor spaces can make a difference to the physiological stress response as well. Using a virtual version of the Trier Social Stress Test, in which the space is computer generated and properties of the space therefore can be systematically varied, we measured saliva cortisol and heart rate variability in participants in a closed room versus a room with openings. As shown by a significant linear contrast interaction between groups and TSST conditions, participants in the closed room responded with more pronounced cortisol reactivity to stress induction, and continued to show higher levels throughout recovery, compared to participants in the open room. No differences were found regarding any part of the autonomic nervous system.
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| 9. |
- Frisvad, Jeppe Revall, et al.
(författare)
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Survey of Models for Acquiring the Optical Properties of Translucent Materials
- 2020
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Ingår i: Computer graphics forum (Print). - : Wiley. - 0167-7055 .- 1467-8659. ; 39, s. 729-755
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Tidskriftsartikel (refereegranskat)abstract
- The outset of realistic rendering is a desire to reproduce the appearance of the real world. Rendering techniques therefore operate at a scale corresponding to the size of objects that we observe with our naked eyes. At the same time, rendering techniques must be able to deal with objects of nearly arbitrary shapes and materials. These requirements lead to techniques that oftentimes leave the task of setting the optical properties of the materials to the user. Matching the appearance of real objects by manual adjustment of optical properties is however nearly impossible. We can render objects with a plausible appearance in this way but cannot compare the appearance of a manufactured item to that of its digital twin. This is especially true in the case of translucent objects, where we need more than a goniometric measurement of the optical properties. In this survey, we provide an overview of forward and inverse models for acquiring the optical properties of translucent materials. We map out the efforts in graphics research in this area and describe techniques available in related fields. Our objective is to provide a better understanding of the tools currently available for appearance specification when it comes to digital representations of real translucent objects.
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| 10. |
- Hansen, Poul Kyvsgaard, et al.
(författare)
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Modular product architecture and organizational structure for continuous innovation
- 2018
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Many companies have adopted a product modularization strategy to deal with the increasing need for more frequent updates and customization of products and services. To realize the benefits there is a ned for developing a modular product and service architecture. But, decisions regarding architecture design require an organizational structure facilitating the inclusion of the holistic cross-functional insight. This paper we will present some findings from our on-going, and planned, research. The focus is on issues related to opportunities and challenges regarding alignment between product architecture and organizational structure in both the developing and the operational phases of a product life cycle. Empirical data has been collected from four different companies, all of them having many years of experience with product modularization. The findings indicate that the alignment between modular product architecture and organisational structure has major effect on the success with modular products in a long-term perspective. To support continuous innovation, the modular architecture needs to be managed, developed and maintained by a dedicated organisation to keep the focus on design for reuse.
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