| 1. |
- Abata, E., et al.
(författare)
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Study of energy response and resolution of the ATLAS barrel calorimeter to hadrons of energies from 20 to 350 GeV
- 2010
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Ingår i: Nuclear Instruments and Methods in Physics Research Section A. - : Elsevier. - 0168-9002 .- 1872-9576 .- 0167-5087. ; 621:1-3, s. 134-150
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Tidskriftsartikel (refereegranskat)abstract
- A fully instrumented slice of the ATLAS detector was exposed to test beams from the SPS (Super Proton Synchrotron) at CERN in 2004. In this paper, the results of the measurements of the response of the barrel calorimeter to hadrons with energies in the range 20-350 GeV and beam impact points and angles corresponding to pseudo-rapidity values in the range 0.2-0.65 are reported. The results are compared to the predictions of a simulation program using the Geant 4 toolkit. (C) 2010 Published by Elsevier B.V.
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| 2. |
- Andersson-Marforio, Sonja, et al.
(författare)
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A survey of the physiotherapy treatment methods for infants hospitalised with acute airway infections in Sweden
- 2021
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Ingår i: European Journal of Physiotherapy. - : Informa UK Limited. - 2167-9169 .- 2167-9177. ; 23:3, s. 149-156
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: The purpose of this study was to investigate what treatment methods physiotherapists in Sweden use for infants 0–24 months hospitalised with acute breathing difficulties due to lower respiratory tract infections. Material and methods: We constructed an anonymous digital survey for paediatric physiotherapists in Sweden. It was distributed by e-mail and was posted on professional websites. Completed forms were obtained from all 21 counties in Sweden. Results: Eighty-eight physiotherapists replied and 52 worked with the target group. Different treatment methods were used, based on the situation and the individual’s symptom. The most common methods involved physical activity and change of the body position. Conclusions: A variety of treatment methods are used by the Swedish physiotherapists. The most commonly used are treatment methods involving frequent changes of the body position and stimulation to physical activity. Thus, the praxis in Sweden seem to differ from methods described in the literature. Methods are chosen depending on the symptoms of the patients. No differences in the choice of treatment methods were found regarding the physiotherapists’ background characteristics.
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| 3. |
- Andersson-Marforio, Sonja, et al.
(författare)
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Physiotherapy interventions encouraging frequent changes of the body position and physical activity for infants hospitalised with bronchiolitis : an internal feasibility study of a randomised control trial
- 2022
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Ingår i: Pilot and Feasibility Studies. - : Springer Science and Business Media LLC. - 2055-5784. ; 8, s. 1-10
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: The effect of a treatment that includes frequent changes of the body position for infants with bronchiolitis has not been evaluated, although it is often used in Swedish hospitals. Because of this, a randomised control trial (RCT) has begun with the aim to evaluate this treatment, comparing the effect of an individualised physiotherapy intervention, a non-individualised intervention, and standard care in a control group. The objective of this internal pilot study was to address uncertainties concerning the ongoing RCT and to determine whether the trial is feasible or not, possibly with adjustments to the protocol.METHODS: Descriptive analyses of the recruitment, retention, data supply for the primary end point, and the usability of the primary outcome measure in the full RCT were performed. A safety analysis was conducted by an independent analysis group.RESULTS: Ninety-one infants were included, 33 (36.3%), 28 (30.8%), and 30 (33.0%) in the respective allocation groups. Fifty-nine (64.8%) were boys. The median age was 2.5 (min-max 0.2-23.7) months. They remained in the study for a median of 46 hours (min-max 2-159). The recruitment rate was 19%. The data supply for the primary end point and for the primary outcome measure was lower than anticipated in the original sample size calculation. Difficulties concerning utilising the primary outcome measure were identified. The safety analysis detected no risks of harm related to participation in the study.CONCLUSIONS: It is feasible to continue the RCT with modifications of the analysis plan. Participation in the study was not associated with any safety risks.TRIAL REGISTRATION: ClinicalTrials.gov NCT03575091 . Registered 2 July 2018. Retrospectively registered.
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| 4. |
- Andersson-Marforio, Sonja, et al.
(författare)
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The effect of physiotherapy including frequent changes of body position and stimulation to physical activity for infants hospitalised with acute airway infections. Study protocol for a randomised controlled trial
- 2020
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Ingår i: Trials. - : Springer Science and Business Media LLC. - 1745-6215. ; 21:1
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Tidskriftsartikel (refereegranskat)abstract
- Background: Every year, many infants are infected with the respiratory syncytial virus (RSV) or other agents and need hospitalisation due to bronchiolitis. The disease causes much suffering and high costs. Thus, it is important that the treatment methods are both effective and cost-efficient. The use of different physiotherapy treatment methods is debated, and not all methods are evaluated scientifically. The clinical praxis in Sweden that includes frequent changes of body position and stimulation to physical activity has not previously been evaluated. The aim of this clinical study is to evaluate this praxis. Methods: This study is a clinical two-centre individually randomised controlled trial (RCT) with three parallel groups. The participants will be randomly assigned to an individualised physiotherapy intervention, a non-individualised intervention, or a control group. All three groups will receive the standard care at the ward, and the two intervention groups will receive additional treatment, including different movements of the body. The primary outcome measure is a clinical index based on determinants for hospitalisation. Baseline assessments will be compared with the assessments after 24 h. The secondary outcome measures include vital signs, the parents' observations, time spent at the hospital ward, and referrals to an intensive care unit. We also want see if there is any immediate effect of the first intervention, after 20 min. Discussion: This study will add knowledge about the effect of two physiotherapy interventions that are commonly in use in Swedish hospitals for infants with bronchiolitis or other acute lower respiratory tract infections. Trial registration: ClinicalTrials.gov NCT03575091. Registered July 2, 2018 - retrospectively registered.
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| 5. |
- Baltag, Alexandru, et al.
(författare)
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Logical Models of Informational Cascades
- 2013
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Ingår i: Logic Across the University: Foundations and Applications. - 9781848901223 ; , s. 405-432
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Bokkapitel (refereegranskat)abstract
- In this paper, we investigate the social herding phenomenon known as informational cascades, in which sequential inter-agent communication might lead to epistemic failures at group level, despite availability of information that should be sufficient to track the truth. We model an example of a cascade, and check the correctness of the individual reasoning of each agent involved, using two alternative logical settings: an existing probabilistic dynamic epistemic logic, and our own novel logic for counting evidence. Based on this analysis, we conclude that cascades are not only likely to occur but are sometimes unavoidable by "rational" means: in some situations, the group’s inability to track the truth is the direct consequence of each agent’s rational attempt at individual truth-tracking. Moreover, our analysis shows that this is even so when rationality includes unbounded higher-order reasoning powers (about other agents’ minds and about the belief-formation-and-aggregation protocol, including an awareness of the very possibility of cascades), as well as when it includes simpler, non-Bayesian forms of heuristic reasoning (such as comparing the amount of evidence pieces).
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| 6. |
- Benatar, Michael, et al.
(författare)
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Safety and efficacy of arimoclomol in patients with early amyotrophic lateral sclerosis (ORARIALS-01) : a randomised, double-blind, placebo-controlled, multicentre, phase 3 trial
- 2024
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Ingår i: Lancet Neurology. - : Elsevier. - 1474-4422 .- 1474-4465. ; 23:7, s. 687-699
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Tidskriftsartikel (refereegranskat)abstract
- Background: Amyotrophic lateral sclerosis is a progressive neurodegenerative disorder leading to muscle weakness and respiratory failure. Arimoclomol, a heat-shock protein-70 (HSP70) co-inducer, is neuroprotective in animal models of amyotrophic lateral sclerosis, with multiple mechanisms of action, including clearance of protein aggregates, a pathological hallmark of sporadic and familial amyotrophic lateral sclerosis. We aimed to evaluate the safety and efficacy of arimoclomol in patients with amyotrophic lateral sclerosis.Methods: ORARIALS-01 was a multinational, randomised, double-blind, placebo-controlled, parallel-group trial done at 29 centres in 12 countries in Europe and North America. Patients were eligible if they were aged 18 years or older and met El Escorial criteria for clinically possible, probable, probable laboratory-supported, definite, or familial amyotrophic lateral sclerosis; had an ALS Functional Rating Scale-Revised score of 35 or more; and had slow vital capacity at 70% or more of the value predicted on the basis of the participant's age, height, and sex. Patients were randomly assigned (2:1) in blocks of 6, stratified by use of a stable dose of riluzole or no riluzole use, to receive oral arimoclomol citrate 1200 mg/day (400 mg three times per day) or placebo. The Randomisation sequence was computer generated centrally. Investigators, study personnel, and study participants were masked to treatment allocation. The primary outcome was the Combined Assessment of Function and Survival (CAFS) rank score over 76 weeks of treatment. The primary outcome and safety were analysed in the modified intention-to-treat population. This trial is registered with ClinicalTrials.gov, NCT03491462, and is completed.Findings: Between July 31, 2018, and July 17, 2019, 287 patients were screened, 245 of whom were enrolled in the trial and randomly assigned. The modified intention-to-treat population comprised 239 patients (160 in the arimoclomol group and 79 in the placebo group): 151 (63%) were male and 88 (37%) were female; mean age was 57·6 years (SD 10·9). CAFS score over 76 weeks did not differ between groups (mean 0·51 [SD 0·29] in the arimoclomol group vs 0·49 [0·28] in the placebo group; p=0·62). Cliff's delta comparing the two groups was 0·039 (95% CI –0·116 to 0·194). Proportions of participants who died were similar between the treatment groups: 29 (18%) of 160 patients in the arimoclomol group and 18 (23%) of 79 patients in the placebo group. Most deaths were due to disease progression. The most common adverse events were gastrointestinal. Adverse events were more often deemed treatment-related in the arimoclomol group (104 [65%]) than in the placebo group (41 [52%]) and more often led to treatment discontinuation in the arimoclomol group (26 [16%]) than in the placebo group (four [5%]).Interpretation: Arimoclomol did not improve efficacy outcomes compared with placebo. Although available biomarker data are insufficient to preclude future strategies that target the HSP response, safety data suggest that a higher dose of arimoclomol would not have been tolerated.Funding: Orphazyme.
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| 7. |
- Dahlberg, Anders, et al.
(författare)
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Den nya rödlistan har 746 svampar
- 2010
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Ingår i: Svensk mykologisk tidskrift. - 1653-0357. ; 31:2, s. 37-47
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Tidskriftsartikel (refereegranskat)abstract
- The new Red List that was recently presented by the Swedish Species Information Centre (Gärdenfors 2010) includes 746 species of fungi considered to be threatened. Compared to the previous Red List published in 2005, 36 species have been down-listed whereas 150 species have been added, thus the list has increased by 114. The changes are above all due to increased knowledge of taxonomy, ecology and distribution. In the present paper members of the Species Specialist Group for Fungi 2006-2010 summarize the background and results of the red-listing process and present the habitats in which the red-listed species occur.
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| 8. |
- Dahlberg, Anders, et al.
(författare)
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Svampar – Fungi
- 2010
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Ingår i: Rödlistade arter i Sverige 2010 – The 2010 Red List of Swedish Species. - 9789188506351 ; , s. 231-246
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 9. |
- Dovemark, Marianne, 1952, et al.
(författare)
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Deregulation, Privatisation and Marketisation of Nordic Comprehensive Education: Social Changes Reflected in Schooling
- 2018
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Ingår i: Education Inquiry. - : Informa UK Limited. - 2000-4508. ; 9:1, s. 122-141
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Tidskriftsartikel (refereegranskat)abstract
- The Nordic countries are often perceived as a coherent group representing the Nordic model of welfare states, with a strong emphasis on the public provision of universal welfare and a strong concern with social equality. But today we see a change in the Nordic model as part of a global knowledge economy. The aim of this article is to examine education in the five Nordic countries utilising three dimensions of political change: deregulation, marketisation and privatisation. We also analyse the parallel changes in relation to segregation and differentiation in education. The analysis shows that the themes related to deregulation seem to show fairly similar patterns and structures in all contexts. The emerging differences were discovered mainly in the themes of marketisation and privatisation. Institutional segregation emerges in all Nordic countries to different extents along the lines of these three processes, and we observe a simultaneous social segregation and differentiation with an ambiguous connection to them. Based on these findings, the question of what is left of the “Nordic model” could be raised.
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| 10. |
- Hansen, Jens Ulrik, et al.
(författare)
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A Logic-Based Approach to Pluralistic Ignorance
- 2014
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Ingår i: Logic and Interactive RAtionality Yearbook 2012, Volume II. ; , s. 226-245
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- “Pluralistic ignorance” is a phenomenon mainly studied in social psychology. Viewed as an epistemic phenomenon, one way to define it is as a situation where “no one believes, but everyone believes that everyone else believes”. In this paper various versions of pluralistic ignorance are formalized using epistemic/doxastic logic (based on plausibility models). The motive is twofold. Firstly, the formalizations are used to show that the various versions of pluralistic ignorance are all consistent, thus there is nothing in the phenomenon that necessarily goes against logic. Secondly, pluralistic ignorance, is on many occasions, assumed to be fragile. In this paper, however, it is shown that pluralistic ignorance need not be fragile to announcements of the agents’ beliefs. Hence, to dissolve pluralistic ignorance in general, something more than announcements of the subjective views of the agents is needed. Finally, suggestions to further research are outlined.
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