| 1. |
- Hansson, Julia, 1978, et al.
(författare)
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Biodiesel from Bark and Black Liquor—A Techno-Economic, Social, and Environmental Assessment
- 2024
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Ingår i: Energies. - Göteborg : IVL Svenska Miljöinstitutet. - 1996-1073 .- 1996-1073. ; 17:1
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Tidskriftsartikel (refereegranskat)abstract
- A techno-economic assessment and environmental and social sustainability assessments of novel Fischer–Tropsch (FT) biodiesel production from the wet and dry gasification of biomass-based residue streams (bark and black liquor from pulp production) for transport applications are presented. A typical French kraft pulp mill serves as the reference case and large-scale biofuel-production-process integration is explored. Relatively low greenhouse gas emission levels can be obtained for the FT biodiesel (total span: 16–83 g CO2eq/MJ in the assessed EU countries). Actual process configuration and low-carbon electricity are critical for overall performance. The site-specific social assessment indicates an overall positive social effect for local community, value chain actors, and society. Important social aspects include (i) job creation potential, (ii) economic development through job creation and new business opportunities, and (iii) health and safety for workers. For social risks, the country of implementation is important. Heat and electricity use are the key contributors to social impacts. The estimated production cost for biobased crude oil is about 13 €/GJ, and it is 14 €/GJ (0.47 €/L or 50 €/MWh) for the FT biodiesel. However, there are uncertainties, i.e., due to the low technology readiness level of the gasification technologies, especially wet gasification. However, the studied concept may provide substantial GHG reduction compared to fossil diesel at a relatively low cost.
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| 2. |
- Andersson, Christian X, 1973, et al.
(författare)
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CD43 has a functional NLS, interacts with beta-catenin, and affects gene expression
- 2004
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Ingår i: Biochem. Biophys. Res. Commun.. - : Elsevier BV. ; 316:1, s. 12-17
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Tidskriftsartikel (refereegranskat)abstract
- CD43 is a transmembrane molecule with a highly O-glycosylated extracellular domain of mucin type. It is a normal constituent of leukocytes and found in colon adenoma, but not in normal colon epithelia. Here it is shown that the cytoplasmic tail of CD43 contains a functional bipartite nuclear localization signal directing it to the nucleus. The intracellular domain of CD43 interacts with beta-catenin and causes an upregulation of the beta-catenin target genes c-MYC and CyclinD1. The present results suggest that CD43 can be involved in nuclear signaling and via beta-catenin interaction be involved in cell proliferation.
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| 3. |
- Andersson, Christian X, 1973, et al.
(författare)
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Shedding and gamma-Secretase mediated intramembrane proteolysis of the mucin-type molecule CD43
- 2005
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Ingår i: Biochem J.. ; 387:2, s. 377-384
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Tidskriftsartikel (refereegranskat)abstract
- CD43 is a transmembrane molecule that contains a 123-aminoacids-long cytoplasmic tail and a highly O-glycosylated extracellular domain of mucin type. Endogenous CD43 expressed in COLO 205, K562 and Jurkat cells revealed a membrane-associated, 20 kDa CD43-specific cytoplasmic tail fragment (CD43-CTF) upon inhibition of gamma-secretase. This fragment was formed by an extracellular cleavage, as it was not accumulated after treating cells with 1,10-phenanthroline, a metalloprotease inhibitor. When CD43 was transfected into HEK-293 cells expressing dominant-negative PS1 (presenilin-1), the CD43-CTF was accumulated, but not in cells with wild-type PS1. Owing to its accumulation in the presence of a non-functional PS variant, it may thus be a novel gamma-secretase substrate. This CTF is formed by an extracellular cleavage close to the membrane, is a fragment that can be concluded to be a substrate for gamma-secretase. However, the intracellular gamma-secretase product has not been possible to detect, suggesting a quick processing of this product. During normal growth the CTF was not found without gamma-secretase inhibition, but when the cells (COLO 205) were very confluent the fragment could be detected. The intracellular domain of CD43 has previously been shown to contain a functional nuclear localization signal, and has been suggested to be involved in gene activation. From this and the present results, a novel way to explain how mucin-type molecules may transduce intracellular signals can be proposed.
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| 4. |
- Andersson, Karin, 1952, et al.
(författare)
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Criteria and Decision Support for A Sustainable Choice of Alternative Marine Fuels
- 2020
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Ingår i: Sustainability. - : MDPI AG. - 2071-1050. ; 12:9, s. 3623-
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Tidskriftsartikel (refereegranskat)abstract
- To reach the International Maritime Organization, IMO, vision of a 50% greenhouse gas (GHG) emission reduction by 2050, there is a need for action. Good decision support is needed for decisions on fuel and energy conversion systems due to the complexity. This paper aims to get an overview of the criteria types included in present assessments of future marine fuels, to evaluate these and to highlight the most important criteria. This is done using a literature review of selected scientific articles and reports and the authors’ own insights from assessing marine fuels. There are different views regarding the goal of fuel change, what fuel names to use as well as regarding the criteria to assess, which therefore vary in the literature. Quite a few articles and reports include a comparison of several alternative fuels. To promote a transition to fuels with significant GHG reduction potential, it is crucial to apply a life cycle perspective and to assess fuel options in a multicriteria perspective. The recommended minimum set of criteria to consider when evaluating future marine fuels differ somewhat between fuels that can be used in existing ships and fuels that can be used in new types of propulsion systems
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| 5. |
- Askman, Sandra, et al.
(författare)
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Decreased neutrophil function in newly diagnosed multiple myeloma patients is restored with lenalidomide therapy
- 2024
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Ingår i: EUROPEAN JOURNAL OF HAEMATOLOGY. - 0902-4441 .- 1600-0609.
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Tidskriftsartikel (refereegranskat)abstract
- ObjectivesBacterial infections are common and a major cause of morbidity and mortality in multiple myeloma (MM). We have investigated the function of polymorphonuclear leukocyte (PMN), the immune system's first line of defense against bacteria, in peripheral blood (PB) and bone marrow (BM) samples from patients with newly diagnosed MM (NDMM), smoldering MM (SMM), monoclonal gammopathy of undetermined significance (MGUS) and healthy controls.MethodsPhagocytosis and oxidative burst in PMN cells from patients and healthy donors were investigated using PhagoTest and PhagoBurst assay.ResultsPMN from NDMM, SMM, and MGUS patients had reduced phagocytosis and oxidative burst ability compared with healthy controls. The dysfunction was most prominent in BM samples from MM, SMM, and MGUS patients. Importantly the reduced phagocytosis in MM patients was restored in patients on lenalidomide therapy. Consistently the ability of Escherichia coli stimulated oxidative burst in BM was reduced for the MM, SMM, and MGUS cohort in contrast to the healthy controls and the patients on lenalidomide treatment.ConclusionOur results show that MM patients have neutrophil dysfunction that could contribute to susceptibility for bacterial infections and that lenalidomide therapy was associated with restored PMN function.
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| 6. |
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| 7. |
- Azar, Christian, 1969, et al.
(författare)
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Brazilian Ethanol has the Edge.
- 2007
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Ingår i: Financial Times.
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 8. |
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| 9. |
- Bahner, Julia, et al.
(författare)
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Access to sexuality : Disabled people's experiences of multiple barriers
- 2021
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Ingår i: Accessibility Denied : Understanding Inaccessibility and Everyday Resistance to Inclusion for Persons with Disabilities - Understanding Inaccessibility and Everyday Resistance to Inclusion for Persons with Disabilities. - 9781003120452 ; , s. 123-139
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Bokkapitel (refereegranskat)abstract
- This chapter concerns disabled people’s experiences of barriers to accessing sexuality. It draws on an analysis of materials produced in ten projects by civil society organisations, including self-advocacy organisations, sexual rights organisations and organisations working on behalf of disabled people. These materials comprise books, handbooks, videos, websites and other online materials, and are based on the lived experiences of people with intellectual disability and mobility impairments. The projects mainly focus on providing information about sexuality and relationships, sexual and gender identity issues, and experiences of disability services in relation to sexuality. The analysis identifies the following types of sexual access barriers: (1) inadequate information, (2) psycho-emotional barriers, (3) relational barriers, (4) support-related barriers, and (5) policy barriers. These barriers to sexual access are often related to general disabling barriers and ableist norms. This intersection of barriers at personal, social, organisational and policy levels greatly impacts on disabled people’s opportunities in their sexual lives specifically, and as equal citizens generally.
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| 10. |
- Barrett, Jennifer H., et al.
(författare)
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Fine mapping of genetic susceptibility loci for melanoma reveals a mixture of single variant and multiple variant regions
- 2015
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Ingår i: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 136:6, s. 1351-1360
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Tidskriftsartikel (refereegranskat)abstract
- At least 17 genomic regions are established as harboring melanoma susceptibility variants, in most instances with genome-wide levels of significance and replication in independent samples. Based on genome-wide single nucleotide polymorphism (SNP) data augmented by imputation to the 1,000 Genomes reference panel, we have fine mapped these regions in over 5,000 individuals with melanoma (mainly from the GenoMEL consortium) and over 7,000 ethnically matched controls. A penalized regression approach was used to discover those SNP markers that most parsimoniously explain the observed association in each genomic region. For the majority of the regions, the signal is best explained by a single SNP, which sometimes, as in the tyrosinase region, is a known functional variant. However in five regions the explanation is more complex. At the CDKN2A locus, for example, there is strong evidence that not only multiple SNPs but also multiple genes are involved. Our results illustrate the variability in the biology underlying genome-wide susceptibility loci and make steps toward accounting for some of the missing heritability. What's new? In genome-wide association studies, researchers identify genetic variants that frequently associate with a particular disease, though the variants identified may not contribute to the molecular cause of the disease. This study took a closer look at 17 regions associated with melanoma, fine mapping the regions both in people with melanoma and in healthy controls. Though single SNPs account for the association in some regions, they found that in a few regions, several SNPs - and possibly multiple genes - contributed to the association signal. These findings illustrate the importance of not overlooking the interaction between multiple genetic markers when conducting such studies.
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