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- Byström, Erik, 1980, et al.
(författare)
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En e-resurs vara eller inte vara. En kvalitativ metod för utvärdering av tidskrifter och databaser.
- 2017
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Ingår i: Förvärv i en föränderlig tid: Nationell konferens om förvärv och samlingsuppbyggnad. Kungliga biblioteket, 1 juni 2017.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Under 2015 och 2016 testade Göteborgs universitetsbibliotek att använda mellansidor som en metod för att utvärdera den kvalitativa användningen av en e-tidskrift eller databas. I Postern presenteras tillvägagångssätt och resultat.
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- Glimelius, Bengt, et al.
(författare)
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U-CAN : a prospective longitudinal collection of biomaterials and clinical information from adult cancer patients in Sweden.
- 2018
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Ingår i: Acta Oncologica. - : Taylor & Francis. - 0284-186X .- 1651-226X. ; 57:2, s. 187-194
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Tidskriftsartikel (refereegranskat)abstract
- Background: Progress in cancer biomarker discovery is dependent on access to high-quality biological materials and high-resolution clinical data from the same cases. To overcome current limitations, a systematic prospective longitudinal sampling of multidisciplinary clinical data, blood and tissue from cancer patients was therefore initiated in 2010 by Uppsala and Umeå Universities and involving their corresponding University Hospitals, which are referral centers for one third of the Swedish population.Material and Methods: Patients with cancer of selected types who are treated at one of the participating hospitals are eligible for inclusion. The healthcare-integrated sampling scheme encompasses clinical data, questionnaires, blood, fresh frozen and formalin-fixed paraffin-embedded tissue specimens, diagnostic slides and radiology bioimaging data.Results: In this ongoing effort, 12,265 patients with brain tumors, breast cancers, colorectal cancers, gynecological cancers, hematological malignancies, lung cancers, neuroendocrine tumors or prostate cancers have been included until the end of 2016. From the 6914 patients included during the first five years, 98% were sampled for blood at diagnosis, 83% had paraffin-embedded and 58% had fresh frozen tissues collected. For Uppsala County, 55% of all cancer patients were included in the cohort.Conclusions: Close collaboration between participating hospitals and universities enabled prospective, longitudinal biobanking of blood and tissues and collection of multidisciplinary clinical data from cancer patients in the U-CAN cohort. Here, we summarize the first five years of operations, present U-CAN as a highly valuable cohort that will contribute to enhanced cancer research and describe the procedures to access samples and data.
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- Neikter, Magnus, 1988-, et al.
(författare)
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Fatigue Crack Growth of Electron Beam Melted Ti-6Al-4V in High-Pressure Hydrogen
- 2020
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Ingår i: Materials. - : MDPI. - 1996-1944. ; 13:6
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Tidskriftsartikel (refereegranskat)abstract
- Titanium-based alloys are susceptible to hydrogen embrittlement (HE), a phenomenon that deteriorates fatigue properties. Ti-6Al-4V is the most widely used titanium alloy and the effect of hydrogen embrittlement on fatigue crack growth (FCG) was investigated by carrying out crack propagation tests in air and high-pressure H2 environment. The FCG test in hydrogen environment resulted in a drastic increase in crack growth rate at a certain Δ K, with crack propagation rates up to 13 times higher than those observed in air. Possible reasons for such behavior were discussed in this paper. The relationship between FCG results in high-pressure H2 environment and microstructure was investigated by comparison with already published results of cast and forged Ti-6Al-4V. Coarser microstructure was found to be more sensitive to HE. Moreover, the electron beam melting (EBM) materials experienced a crack growth acceleration in-between that of cast and wrought Ti-6Al-4V.
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- Robinson, Jonathan, 1986, et al.
(författare)
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An atlas of human metabolism
- 2020
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Ingår i: Science Signaling. - : American Association for the Advancement of Science (AAAS). - 1945-0877 .- 1937-9145. ; 13:624
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Tidskriftsartikel (refereegranskat)abstract
- Genome-scale metabolic models (GEMs) are valuable tools to study metabolism and provide a scaffold for the integrative analysis of omics data. Researchers have developed increasingly comprehensive human GEMs, but the disconnect among different model sources and versions impedes further progress. We therefore integrated and extensively curated the most recent human metabolic models to construct a consensus GEM, Human1. We demonstrated the versatility of Human1 through the generation and analysis of cell- and tissue-specific models using transcriptomic, proteomic, and kinetic data. We also present an accompanying web portal, Metabolic Atlas (https://www.metabolicatlas.org/), which facilitates further exploration and visualization of Human1 content. Human1 was created using a version-controlled, open-source model development framework to enable community-driven curation and refinement. This framework allows Human1 to be an evolving shared resource for future studies of human health and disease.
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| 7. |
- Sjöland, Helen, 1959, et al.
(författare)
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Pulmonary embolism and deep venous thrombosis after COVID-19: long-term risk in a population-based cohort study
- 2023
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Ingår i: Research and Practice in Thrombosis and Haemostasis. - 2475-0379. ; 7:5
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Tidskriftsartikel (refereegranskat)abstract
- Background: Venous thromboembolism (VTE) (pulmonary embolism [PE] or deep venous thrombosis [DVT]) is common during acute COVID-19. Long-term excess risk has not yet been established. Objectives: To study long-term VTE risk after COVID-19. Methods: Swedish citizens aged 18 to 84 years hospitalized and/or testing positive for COVID-19 between January 1, 2020, and September 11, 2021 (exposed), stratified by initial hospitalization, were compared to matched (1:5), nonexposed, population-derived subjects without COVID-19. Outcomes were incident VTE, PE, or DVT recorded within 60, 60 to <180, and & GE;180 days. Cox regression was used for evalu-ation, and a model adjusted for age, sex, comorbidities, and socioeconomic markers was developed to control for confounders. Results: Among exposed patients, 48,861 were hospitalized for COVID-19 (mean age, 60.6 years) and 894,121 were without hospitalization (mean age, 41.4 years). Among patients hospitalized for COVID-19, fully adjusted hazard ratios during 60 to <180 days were 6.05 (95% CI, 4.80-7.62) for PE and 3.97 (CI, 2.96-5.33) for DVT compared with that for nonexposed patients with corresponding estimates among those with COVID-19 without hospitalization 1.17 (CI, 1.01-1.35) and 0.99 (CI, 0.86-1.15), based on 475 and 2311 VTE events, respectively. Long-term (& GE;180 days) hazard ratios in patients hospitalized for COVID-19 were 2.01 (CI, 1.51-2.68) for PE and 1.46 (CI, 1.05-2.01) for DVT, while nonhospitalized patients had similar risk as nonexposed patients, based on 467 and 2030 VTE events, respectively. Conclusion: Patients hospitalized for COVID-19 retained an elevated excess risk of VTE, mainly PE, after 180 days, while long-term risk of VTE in individuals with COVID-19 without hospitalization was similar to that in the nonexposed patients.
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