| 1. |
|
|
| 2. |
- Barywani, Salim B., 1968, et al.
(författare)
-
Body iron stores had no impact on coronary heart disease outcomes: a middle-aged male cohort from the general population with 21-year follow-up
- 2022
-
Ingår i: Open Heart. - : BMJ. - 2053-3624. ; 9:1
-
Tidskriftsartikel (refereegranskat)abstract
- Background Body iron stores (BISs) have been proposed to be related to the development of cardiovascular diseases. However, results from epidemiological studies are conflicting. Knowledge on the long-term impact of BIS on cardiovascular outcomes in the general population is lacking. Purpose The aim of this study was to explore the relationship between BIS and coronary heart disease (CHD) including death due to CHD. Methods This investigation is part of 'The Study of Men Born in 1943', a longitudinal prospective study of men living in the city of Gothenburg, Sweden. This random population sample was examined in 1993 (all at 50 years of age at baseline). A medical examination was performed, and questionnaires were used to evaluate lifestyle factors. Biomarkers for iron stores (serum ferritin and serum transferrin receptor) was analysed from frozen blood samples in 2014. All hospital admissions were registered through national registers during the entire follow-up from 1993 to 2014. HRs were estimated by Cox proportional-hazard regression analyses. Results During the 21 years follow-up period, 120 participants (15.2%) developed CHD and 16 patients (2%) died due to CHD. The all-cause mortality was 15.2% (n=120) including 40 cardiovascular deaths (5.1%). In a multivariable Cox regression analysis, the daily smoking, hypertension and the increased resting heart rate was independent predictors of CHD, while no significant association was found between BIS and risk of CHD. Conclusions In a cohort of middle-aged men from the general population with well validated and prospectively collected data, we did not find any association between serum ferritin or serum transferrin receptor as markers of BIS and CHD events after 21 years of follow-up.
|
|
| 3. |
- Barywani, Salim B., 1968, et al.
(författare)
-
Impact of elevated systolic arterial pulmonary pressure on the total mortality rate after acute myocardial infarction in the elderly
- 2022
-
Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 12:1
-
Tidskriftsartikel (refereegranskat)abstract
- Reduced left ventricular ejection fraction (LVEF) is associated with increased mortality after acute myocardial infarction (AMI). However, the prognostic impact of elevated systolic pulmonary artery pressure (sPAP) in the very elderly patients after AMI is lacking. We aimed to study the impact of elevated sPAP on one- and five-year all-cause mortality after AMI in very elderly patients, 80 years of age and older. Of a total number of 353 patients (>= 80 years) who were hospitalized with acute coronary syndrome, 162 patients presenting with AMI and with available data of sPAP on echocardiography were included and followed-up for 5 years. The survival analyses were performed using Cox-Regression models adjusted for conventional risk factors including LVEF. Altogether 66 of 162 patients (41%) had ST-segment elevation MI, and 121 (75%) of patients were treated with percutaneous coronary intervention in the acute phase. Echocardiography during the admission revealed that 78 patients (48%) had a LVEF <= 45% and 66 patients (41%) had a sPAP >= 40 mmHg. After one and five years of follow-up, 23% (n = 33) and 53% (n = 86) of patients died, respectively. A multivariable Cox-Regression analysis showed that the elevated sPAP (>= 40 mmHg) was an independent predictor of increased mortality in both one and five years after AMI; HR of 2.63 (95%, CI 1.19-5.84, P 0.017) and HR of 2.08 (95%, CI 1.25-3.44, P 0.005) respectively, whereas LVEF <= 45% did not show any statistically significant impact, neither on one- nor on five-year mortality (HR 1.3, 95% CI 0.6-2.9, p = 0.469) and (HR 1.4, 95% CI 0.8-2.4, p = 0.158), respectively. Elevated sPAP was an independent risk factor for one- and five-year all-cause mortality after AMI in very elderly patients and sPAP seems to be a better prognostic predictor for all-cause mortality than LVEF. The risk of all-cause mortality after AMI increased with increasing sPAP.
|
|
| 4. |
- Chen, Xiaojing, et al.
(författare)
-
High-normal blood pressure conferred higher risk of cardiovascular disease in a random population sample of 50-year-old men: A 21-year follow-up.
- 2020
-
Ingår i: Medicine. - 1536-5964. ; 99:17
-
Tidskriftsartikel (refereegranskat)abstract
- The relationship between various categories of blood pressure (BP), subtypes of hypertension, and development of cardiovascular disease (CVD) have not been extensively studied. Therefore, our study aimed to explore this relationship in a random population sample of men born in 1943, living in Sweden and followed over a 21-year period.Participants were examined for the first time in 1993 (age 50 years), where data on medical history, concomitant diseases, and general health were collected. The examination was repeated in 2003 and with additional echocardiography also in 2014. Classification of participants according to their BP at the age of 50 years was as follows: optimal-normal BP (systolic blood pressure [SBP] <130 and diastolic BP [DBP] <85mmHg), high-normal BP (130≤SBP<140, 85≤DBP<90mmHg), isolated systolic-diastolic hypertension (ISH-IDH) (SBP ≥140 and DBP <90 or SBP <140 and DBP ≥90mmHg), and systolic-diastolic hypertension (SDH) (SBP ≥140 and DBP ≥90mmHg).During the follow-up, the incidence of heart failure (HF), CVD, and coronary heart disease were all lowest for those with optimal-normal BP. Participants with high-normal BP showed greater wall thickness and left ventricular mass index, larger LV size and larger left atrial size when compared with the optimal-normal BP group. Furthermore, those with high-normal BP, ISH-IDH, and SDH had a higher risk of CVD than those with optimal-normal BP. The adjusted relative risk of CVD was highest for SDH (hazard ratio [HR] 1.95; 95% confidence interval [95% CI] 1.37-2.79), followed by ISH-IDH (HR 1.34; 95% CI 0.93-1.95) and high-normal BP (HR 1.31; 95% CI 0.91-1.89).Over a 21-year follow-up, the participants with high-normal BP or ISH-IDH had a higher relative risk of CVD than those with optimal-normal BP.
|
|
| 5. |
- Chen, Xiaojing, et al.
(författare)
-
Impact of changes in heart rate with age on all-cause death and cardiovascular events in 50-year-old men from the general population
- 2019
-
Ingår i: Open Heart. - : BMJ. - 2053-3624. ; 6:1
-
Tidskriftsartikel (refereegranskat)abstract
- Background Resting heart rate (RHR), a known cardiovascular risk factor, changes with age. However, little is known about the association between changes in RHR and the risk of cardiovascular events. The purpose of this study was therefore to assess the impact of RHR at baseline, and the change in RHR over time, on the risk of all-cause death and cardiovascular events. Design A random population sample of men born in 1943 who were living in Gothenburg, Sweden was prospectively followed for a 21-year period. Methods Participants were examined three times: first in 1993 and then re-examined in 2003 and 2014. At each visit, a clinical examination, an ECG and laboratory analyses were performed. Change in RHR between 1993 and 2003 was defined as a decrease if RHR decreased by 5 beats per minute (bpm), an increase if RHR increased by 5 bpm or stable if the RHR change was <4bpm). Results Participants with a baseline RHR of >75 bpm in 1993 had about a twofold higher risk of all-cause death (HR 2.3, CI 1.2 to 4.7, p=0.018), cardiovascular disease (CVD) (HR 1.8, CI 1.1 to 3.0, p=0.014) and coronary heart disease (CHD) (HR 2.2, CI 1.1 to 4.5, p=0.025) compared with those with <55 bpm in 1993. Participants with a stable RHR between 1993 and 2003 had a 44% decreased risk of CVD (HR 0.56, CI 0.35 to 0.87, p=0.011) compared with participants with an increasing RHR. Furthermore, every beat increase in heart rate from 1993 was associated with a 3% higher risk for all-cause death, 1% higher risk for CVD and 2% higher risk for CHD. Conclusion High RHR was associated with an increased risk of death and cardiovascular events in men from the general population. Moreover, individuals with an increase in RHR between 50 and 60 years of age had worse outcome. © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
|
|
| 6. |
- Dahlström, Örjan, 1973-, et al.
(författare)
-
Efficacy of pre-participation cardiac evaluation recommendations among athletes participating in World Athletics Championships
- 2020
-
Ingår i: European Journal of Preventive Cardiology. - : Sage Publications. - 2047-4873 .- 2047-4881. ; 27:14, s. 1480-1490
-
Tidskriftsartikel (refereegranskat)abstract
- Background Athletes competing in athletics (track and field) at international level may be participating with underlying undiagnosed life-threatening cardiovascular conditions. Our objective was to analyse variations in pre-participation cardiac evaluation prevalence among athletes participating in two International Association of Athletics Federations (IAAF) World Athletics Championships, with regard to the human developmental level and global region of their home countries, as well as athletes’ age category, gender, event group and medical insurance type.Design Cross-sectional web-based survey.MethodsA total of 1785 athletes competing in the IAAF World Under 18 Championships Nairobi 2017 and World Championships London 2017 were invited to complete a pre-participation health questionnaire investigating the experience of a pre-participation cardiac examination.Results A total of 704 (39%) of the athletes participated. Among these, 59% (60% of women; 58% of men) reported that they had been provided at least one type of pre-participation cardiac evaluation. Athletes from very high income countries, Europe and Asia, showed a higher prevalence of at least one pre-participation cardiac evaluation.Conclusions The prevalence of pre-participation cardiac evaluation in low to middle income countries, and the African continent in particular, needs urgent attention. Furthermore, increases in evaluation prevalence should be accompanied by the development of cost-effective methods that can be adopted in all global regions.
|
|
| 7. |
-
Digitalisering av lärares undervisning : Översikt och exempel från examensarbeten vid ämneslärarprogrammet i samhällskunskap
- 2020
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Denna publikation är en del av rapportserien DINO – Digitalisering i nya offentligheter. Syftet med rapportserien är att publicera tidiga forskningsresultat som handlar om samhällets digitalisering i vid mening, och särskilt det som sker inom och i relation till offentliga verksamheter.Digitaliseringen av skolan handlar om ett offentligt sammanhang i allra högsta grad. Och bland lärarstudenterna som vi handleder på ämneslärarprogrammet i samhällsvetenskap har kraven på att arbeta med digitala verktyg och att ha digital kompetens fångat mångas intresse och uppmärksamhet. Vi vill därför ge en inblick i den kunskap som skapas kring temat i den här rapporten. Rapporten vänder sig till en intresserad allmänhet, men även forskare och universitetslärare som undervisar lärarstudenter, lärarstudenter som står i startgroparna för att skriva examensarbeten, samt aktiva lärare som vill få inblick i kollegors utmaningar och tillvägagångssätt när det gäller digitaliseringen och användningen av digitala verktyg i undervisningen.I rapporten vill vi dela med oss av relevanta sätt att studera och förstå hur lärare i grundskola och på gymnasiet kan undervisa med digitala verktyg, hur studenterna kan arbeta för att fånga detta, samt visa på resultat som framkommit ur examensarbetena.
|
|
| 8. |
|
|
| 9. |
- Hansson, Per-Olof, 1968-, et al.
(författare)
-
Frontrunners in ICT : Kenyan runners’ improvement in training, informal learning and economic opportunities using smartphones
- 2014
-
Ingår i: ijEDict - International Journal of Education and Development using Information and Communication Technology. - 1814-0556. ; 10:4, s. 4-20
-
Tidskriftsartikel (refereegranskat)abstract
- The primary aim of this research was to study how mobile technology shapes, changes, and develops informal learning outside the classroom and school environment. In this study we provided each of the 30 Kenyan elite runners with a simple Android smartphone and free Internet for one year. This research project was a developmental intervention with a participatory action research approach, and aimed to facilitate innovation and examine how the runners developed their training, informal learning, and economic opportunities using a smartphone. Logs and tracking of smartphone usage recorded quantitative data, and interviews and participatory observations gathered qualitative data. Key findings were that the smartphone improved the runners’ training and race performance and created business opportunities. Second, a smartphone with an Internet connection empowered marginalized groups and augmented informal learning opportunities. Third, that a smartphone was not a significant technological hurdle for impoverished or uneducated individuals. Fourth, the participants were able to learn with little or no guidance or scaffolding. Fifth, the tracking log data indicated both a breadth and depth to individual learning. This participatory action research made a significant impact on the participants’ lives and the most common statement from the interviews was the statement “it helps us a lot”.
|
|
| 10. |
|
|
