| 1. |
- Fockler, J., et al.
(författare)
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Remote blood collection from older adults in the Brain Health Registry for plasma biomarker and genetic analysis
- 2022
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Ingår i: Alzheimer's and Dementia. - : Wiley. - 1552-5260 .- 1552-5279. ; 18:12, s. 2627-2636
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Tidskriftsartikel (refereegranskat)abstract
- Introduction: Use of online registries to efficiently identify older adults with cognitive decline and Alzheimer's disease (AD) is an approach with growing evidence for feasibility and validity. Linked biomarker and registry data can facilitate AD clinical research. Methods: We collected blood for plasma biomarker and genetic analysis from older adult Brain Health Registry (BHR) participants, evaluated feasibility, and estimated associations between demographic variables and study participation. Results: Of 7150 participants invited to the study, 864 (12%) enrolled and 629 (73%) completed remote blood draws. Participants reported high study acceptability. Those from underrepresented ethnocultural and educational groups were less likely to participate. Discussion: This study demonstrates the challenges of remote blood collection from a large representative sample of older adults. Remote blood collection from>600 participants within a short timeframe demonstrates the feasibility of our approach, which can be expanded for efficient collection of plasma AD biomarker and genetic data. © 2022 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
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| 2. |
- Benisty, H., et al.
(författare)
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Low-loss photonic-crystal and monolithic InP integration : Bands, bends, lasers, filters
- 2004
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Ingår i: Photonic Crystal Materials and Devices II. - : SPIE - International Society for Optical Engineering. - 0819452688 ; , s. 119-128
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Konferensbidrag (refereegranskat)abstract
- Practical realizations of 2D (planar) photonics crystal (PhC) are either on a membrane or etched through a conventional heterostructure. While fascinating objects can emerge from the first approach, only the latter approach lends itself to a progressive integration of more compact PhC's towards monolithic PICs based on InP. We describe in this talk the various aspects from technology to functions and devices, as emerged from the European collaboration "PCIC". The main technology tour de force is deep-etching with aspect ratio of about 10 and vertical sidewall, achieved by three techniques (CAIBE, ICP-RIE, ECR-RIE). The basic functions explored are bends, splitters/combiners, mirrors, tapers, and the devices are filters and lasers. At the end of the talk, I will emphasize some positive aspects of "broad" multimode PhC waveguides, in view of compact add-drop filtering action, notably.
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| 3. |
- Happ, T. D., et al.
(författare)
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Single-mode operation of coupled-cavity lasers based on two-dimensional photonic crystals
- 2001
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Ingår i: Applied Physics Letters. - : AIP Publishing. - 0003-6951 .- 1077-3118. ; 79:25, s. 4091-4093
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Tidskriftsartikel (refereegranskat)abstract
- We report the fabrication of short-cavity lasers with highly reflective two-dimensional photonic crystal mirrors on an InGaAsP/InP laser structure emitting at 1.57 mum. An intracavity photonic crystal mirror creates two coupled cavities, which provide additional longitudinal mode selection for stable single-mode operation with side-mode suppression ratios exceeding 35 dB. The shortest lasers with l=100 mum overall length have a threshold current of 13 mA and provide more than 4 mW power under continuous wave operation. Longer devices with l=200 mum deliver up to 9 mW. A maximum modulation bandwidth of 7.9 GHz was determined by relative intensity noise measurements.
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| 4. |
- Kamp, M., et al.
(författare)
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Photonic crystal based active optoelectronic devices
- 2006
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Ingår i: Photonic Crystals: Advances in Design, Fabrication, and Characterization. - Weinheim, FRG : Wiley-Blackwell. - 9783527602599 ; , s. 329-346
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- We have described a number of ways to integrate photonic crystals with active optoelectronic devices. PhCs can be used as mirrors in semiconductor lasers where their high reflectivity allow the fabrication of lasers with small cavity length. Lasers with a length down to 100 μm and two PhC mirrors have been demonstrated.
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| 5. |
- Kamp, M., et al.
(författare)
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Semiconductor photonic crystals for optoelectronics
- 2004
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Ingår i: Physica. E, Low-Dimensional systems and nanostructures. - : Elsevier BV. - 1386-9477 .- 1873-1759. ; 21:2-4, s. 802-808
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Tidskriftsartikel (refereegranskat)abstract
- We present a number of designs for the integration of photonic crystals (PC) with active semiconductor devices. As a first step, the use of PC blocks as laser mirrors is demonstrated. Ridge-waveguide lasers with a length of 100 mum and two PC mirrors achieve threshold currents below 8 mA. In order to obtain single-mode operation, an intracavity PC mirror can be used, which effectively separates the laser into two coupled cavities. Lasing occurs where two modes of the cavities coincide, leading to single-mode operation with a side-mode suppression ratio (SMSR) of over 35 dB. We also present two full PC devices: a single-mode laser with a coupled resonant cavity waveguide (CROW) and a tunable laser. The CROW device consists of a chain of 40 hexagonal cavities formed in a block of PC, with a total length of 140 mum. Low threshold, single-mode operation with over 40 dB SMSR is demonstrated. Coupled cavities are used for the tunable PC laser, which covers a tuning range of over 30 nm.
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| 6. |
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