| 1. |
- Abbott, Benjamin W., et al.
(författare)
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Biomass offsets little or none of permafrost carbon release from soils, streams, and wildfire : an expert assessment
- 2016
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Ingår i: Environmental Research Letters. - : IOP Publishing. - 1748-9326. ; 11:3
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Tidskriftsartikel (refereegranskat)abstract
- As the permafrost region warms, its large organic carbon pool will be increasingly vulnerable to decomposition, combustion, and hydrologic export. Models predict that some portion of this release will be offset by increased production of Arctic and boreal biomass; however, the lack of robust estimates of net carbon balance increases the risk of further overshooting international emissions targets. Precise empirical or model-based assessments of the critical factors driving carbon balance are unlikely in the near future, so to address this gap, we present estimates from 98 permafrost-region experts of the response of biomass, wildfire, and hydrologic carbon flux to climate change. Results suggest that contrary to model projections, total permafrost-region biomass could decrease due to water stress and disturbance, factors that are not adequately incorporated in current models. Assessments indicate that end-of-the-century organic carbon release from Arctic rivers and collapsing coastlines could increase by 75% while carbon loss via burning could increase four-fold. Experts identified water balance, shifts in vegetation community, and permafrost degradation as the key sources of uncertainty in predicting future system response. In combination with previous findings, results suggest the permafrost region will become a carbon source to the atmosphere by 2100 regardless of warming scenario but that 65%-85% of permafrost carbon release can still be avoided if human emissions are actively reduced.
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| 2. |
- Dantonello, Tobias M, et al.
(författare)
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Cooperative trial CWS-91 for localized soft tissue sarcoma in children, adolescents, and young adults.
- 2009
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Ingår i: Journal of clinical oncology : official journal of the American Society of Clinical Oncology. - 1527-7755. ; 27:9, s. 1446-55
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Tidskriftsartikel (refereegranskat)abstract
- PURPOSE: To improve risk-adapted therapy for localized childhood soft tissue sarcoma within an international multicenter setting. PATIENTS AND METHODS: Four hundred forty-one patients younger than 21 years with localized rhabdomyosarcoma and rhabdomyosarcoma-like tumors (ie, extraosseous tumors of the Ewing family, synovial sarcoma, and undifferentiated sarcoma) were eligible. Therapy was stratified according to postsurgical stage, histology, and tumor site. In unresectable tumors, treatment was further adapted depending on response to induction chemotherapy, TN classification, tumor size and second-look surgery. A novel five-drug combination of etoposide, vincristine, dactinomycin, ifosfamide, and doxorubicin (EVAIA) was evaluated for high-risk patients, but cumulative chemotherapy dosage and treatment duration were reduced for the remaining individuals as compared with that of the previous trial CWS-86. Hyperfractionated accelerated radiotherapy (HART) was recommended at doses of either 32 or 48 Gy. RESULTS: At a median follow-up of 8 years, 5-year event-free survival (EFS) and overall (OS) survival for the entire cohort was 63% +/- 4% and 73% +/- 4%, respectively (all survival rates in this abstract are calculated and displayed with +/-95% CI). EFS/OS rates by histology were 60% +/- 5%/72% +/- 5% in rhabdomyosarcoma, 62% +/- 10%/69% +/- 10% for Ewing tumors of soft tissues, 84% +/- 12%/90% +/- 10% for synovial sarcoma, and 67% +/- 38%/83% +/- 30% for undifferentiated sarcoma, respectively. Response to one cycle of the five-drug combination EVAIA was similar to that of the four-drug combination VAIA used in CWS-86. Two hundred twelve patients with rhabdomyosarcoma underwent radiation (EFS, 66% +/- 6%); 53 of those patients had a favorable risk profile and received 32 Gy of HART (EFS, 73% +/- 12%). TN classification, tumor site, tumor size, histology, and age were prognostic in univariate analysis. CONCLUSION: Improved risk stratification enabled decreased therapy intensity for selected patients without compromising survival. Intensified chemotherapy with EVAIA did not improve outcome of localized high-risk rhabdomyosarcoma.
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| 3. |
- Dvouletý, Ondřej, et al.
(författare)
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Scaling the right answers – Creating and maintaining hope through social entrepreneurship in light of humanitarian crises
- 2023
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Ingår i: Journal of Business Venturing Insights. - : Elsevier Inc.. - 2352-6734. ; 19
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Tidskriftsartikel (refereegranskat)abstract
- Triggered by the Russo–Ukrainian war starting early in 2022 and the subsequent movement of refugees toward various European countries, this rapid response paper provides five reflections on the role of social entrepreneurship in light of humanitarian crises. We validate two problems with the help of a problem owner from social entrepreneurial practice and suggest answers to them grounded in existing evidence documented in the academic literature (translational research approach). First, we show how social entrepreneurs can focus on solving the right problems in chaotic and fast-paced crises, and second, we illustrate measures to scale appropriately. Finally, on a meta-level, hope emerges as an additional answer. Even if social entrepreneurs should not address the “right” problems and even if they scale inappropriately, in light of any humanitarian crises, they still contribute value by creating hope for their societies, their stakeholders, and for themselves. © 2022 The Authors
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| 4. |
- Fink, Matthias, et al.
(författare)
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Ethical Orientation and Research Misconduct Among Business Researchers Under the Condition of Autonomy and Competition
- 2023
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Ingår i: Journal of Business Ethics. - : Springer Science and Business Media LLC. - 0167-4544 .- 1573-0697. ; 183:2, s. 619-636
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Tidskriftsartikel (refereegranskat)abstract
- The topics of ethical conduct and governance in academic research in the business field have attracted scientific and public attention. The concern is that research misconduct in organizations such as business schools and universities might result in practitioners, policymakers, and researchers grounding their decisions on biased research results. This study addresses ethical research misconduct by investigating whether the ethical orientation of business researchers is related to the likelihood of research misconduct, such as selective reporting of research findings. We distinguish between deontological and consequentialist ethical orientations and the competition between researchers and investigate the moderating role of their perceived autonomy. Based on global data collected from 1031 business scholars, we find that researchers with a strong deontological ethical orientation are less prone to misconduct. This effect is robust against different levels of perceived autonomy and competition. In contrast, researchers having a consequentialist ethical orientation is positively associated with misconduct in business research. High levels of competition in the research environment reinforce this effect. Our results reveal a potentially toxic combination comprising researchers with a strong consequentialist orientation who are embedded in highly competitive research environments. Our research calls for the development of ethical orientations grounded on maxims rather than anticipated consequences among researchers. We conclude that measures for ethical governance in business schools should consider the ethical orientation that underlies researchers’ decision-making and the organizational and institutional environment in which business researchers are embedded.
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| 5. |
- Kraus, Sascha, et al.
(författare)
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Diskussionslinien der Entrepreneurial Marketing – Forschung: Ergebnisse einer Zitationsanalyse
- 2011
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Ingår i: Zeitschrift für Betriebswirtschaft. - : Springer. - 0044-2372 .- 1861-8928. ; :6, s. 27-58
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Tidskriftsartikel (refereegranskat)abstract
- Abstract: Entrepreneurial Marketing (EM) is a research field that grows dynamically and that seems to be heterogeneous. Heterogeneity of a research field exacerbates the orientation in and the advancement of the field. Therefore, this article strives to inventarize the EM-literature and thereby to identify key discussion lines of EM research.Based on a comprehensive literature analysis, we first outline the history of EM research, and identify core authors and core journal Based on a citation analysis of 199 EM papers with a total of 6,222 references and an ensuing expert evaluation, we identify four key discussion lines: (1) theoretical foundations, (2) entrepreneurship-marketing interface, (3) new venture- and SME-marketing, and (4) EM in the sense of innovative, proactive and risk-oriented marketing. These four discussion lines and the respective literature constitute a framework for the advancement of EM research.
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