| 1. |
- Engert, Andreas, et al.
(författare)
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The European Hematology Association Roadmap for European Hematology Research : a consensus document
- 2016
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Ingår i: Haematologica. - Pavia, Italy : Ferrata Storti Foundation (Haematologica). - 0390-6078 .- 1592-8721. ; 101:2, s. 115-208
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Tidskriftsartikel (refereegranskat)abstract
- The European Hematology Association (EHA) Roadmap for European Hematology Research highlights major achievements in diagnosis and treatment of blood disorders and identifies the greatest unmet clinical and scientific needs in those areas to enable better funded, more focused European hematology research. Initiated by the EHA, around 300 experts contributed to the consensus document, which will help European policy makers, research funders, research organizations, researchers, and patient groups make better informed decisions on hematology research. It also aims to raise public awareness of the burden of blood disorders on European society, which purely in economic terms is estimated at (sic)23 billion per year, a level of cost that is not matched in current European hematology research funding. In recent decades, hematology research has improved our fundamental understanding of the biology of blood disorders, and has improved diagnostics and treatments, sometimes in revolutionary ways. This progress highlights the potential of focused basic research programs such as this EHA Roadmap. The EHA Roadmap identifies nine 'sections' in hematology: normal hematopoiesis, malignant lymphoid and myeloid diseases, anemias and related diseases, platelet disorders, blood coagulation and hemostatic disorders, transfusion medicine, infections in hematology, and hematopoietic stem cell transplantation. These sections span 60 smaller groups of diseases or disorders. The EHA Roadmap identifies priorities and needs across the field of hematology, including those to develop targeted therapies based on genomic profiling and chemical biology, to eradicate minimal residual malignant disease, and to develop cellular immunotherapies, combination treatments, gene therapies, hematopoietic stem cell treatments, and treatments that are better tolerated by elderly patients.
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| 2. |
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| 3. |
- Kattge, Jens, et al.
(författare)
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TRY plant trait database - enhanced coverage and open access
- 2020
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Ingår i: Global Change Biology. - : Wiley-Blackwell. - 1354-1013 .- 1365-2486. ; 26:1, s. 119-188
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Tidskriftsartikel (refereegranskat)abstract
- Plant traits-the morphological, anatomical, physiological, biochemical and phenological characteristics of plants-determine how plants respond to environmental factors, affect other trophic levels, and influence ecosystem properties and their benefits and detriments to people. Plant trait data thus represent the basis for a vast area of research spanning from evolutionary biology, community and functional ecology, to biodiversity conservation, ecosystem and landscape management, restoration, biogeography and earth system modelling. Since its foundation in 2007, the TRY database of plant traits has grown continuously. It now provides unprecedented data coverage under an open access data policy and is the main plant trait database used by the research community worldwide. Increasingly, the TRY database also supports new frontiers of trait-based plant research, including the identification of data gaps and the subsequent mobilization or measurement of new data. To support this development, in this article we evaluate the extent of the trait data compiled in TRY and analyse emerging patterns of data coverage and representativeness. Best species coverage is achieved for categorical traits-almost complete coverage for 'plant growth form'. However, most traits relevant for ecology and vegetation modelling are characterized by continuous intraspecific variation and trait-environmental relationships. These traits have to be measured on individual plants in their respective environment. Despite unprecedented data coverage, we observe a humbling lack of completeness and representativeness of these continuous traits in many aspects. We, therefore, conclude that reducing data gaps and biases in the TRY database remains a key challenge and requires a coordinated approach to data mobilization and trait measurements. This can only be achieved in collaboration with other initiatives.
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| 4. |
- Archambault, Alexi N., et al.
(författare)
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Cumulative Burden of Colorectal Cancer Associated Genetic Variants Is More Strongly Associated With Early-Onset vs Late-Onset Cancer
- 2020
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Ingår i: Gastroenterology. - : Elsevier BV. - 0016-5085 .- 1528-0012. ; 158:5, s. 1274-1286.e12
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND & AIMS: Early-onset colorectal cancer (CRC, in persons younger than 50 years old) is increasing in incidence; yet, in the absence of a family history of CRC, this population lacks harmonized recommendations for prevention. We aimed to determine whether a polygenic risk score (PRS) developed from 95 CRC-associated common genetic risk variants was associated with risk for early-onset CRC.METHODS: We studied risk for CRC associated with a weighted PRS in 12,197 participants younger than 50 years old vs 95,865 participants 50 years or older. PRS was calculated based on single nucleotide polymorphisms associated with CRC in a large-scale genome-wide association study as of January 2019. Participants were pooled from 3 large consortia that provided clinical and genotyping data: the Colon Cancer Family Registry, the Colorectal Transdisciplinary Study, and the Genetics and Epidemiology of Colorectal Cancer Consortium and were all of genetically defined European descent. Findings were replicated in an independent cohort of 72,573 participants.RESULTS: Overall associations with CRC per standard deviation of PRS were significant for early-onset cancer, and were stronger compared with late-onset cancer (P for interaction = .01); when we compared the highest PRS quartile with the lowest, risk increased 3.7-fold for early-onset CRC (95% CI 3.28-4.24) vs 2.9-fold for late-onset CRC (95% CI 2.80-3.04). This association was strongest for participants without a first-degree family history of CRC (P for interaction = 5.61 x 10(-5)). When we compared the highest with the lowest quartiles in this group, risk increased 4.3-fold for early-onset CRC (95% CI 3.61-5.01) vs 2.9-fold for late-onset CRC (95% CI 2.70-3.00). Sensitivity analyses were consistent with these findings.CONCLUSIONS: In an analysis of associations with CRC per standard deviation of PRS, we found the cumulative burden of CRC-associated common genetic variants to associate with early-onset cancer, and to be more strongly associated with early-onset than late-onset cancer, particularly in the absence of CRC family history. Analyses of PRS, along with environmental and lifestyle risk factors, might identify younger individuals who would benefit from preventive measures.
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| 5. |
- Evans, P. A., et al.
(författare)
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Swift and NuSTAR observations of GW170817 : Detection of a blue kilonova
- 2017
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 358:6370, s. 1565-1569
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Tidskriftsartikel (refereegranskat)abstract
- With the first direct detection of merging black holes in 2015, the era of gravitational wave (GW) astrophysics began. A complete picture of compact object mergers, however, requires the detection of an electromagnetic (EM) counterpart. We report ultraviolet (UV) and x-ray observations by Swift and the Nuclear Spectroscopic Telescope Array of the EM counter part of the binary neutron star merger GW170817. The bright, rapidly fading UV emission indicates a high mass (approximate to 0.03 solar masses) wind-driven outflow with moderate electron fraction (Y-e approximate to 0.27). Combined with the x-ray limits, we favor an observer viewing angle of approximate to 30 degrees away from the orbital rotation axis, which avoids both obscuration from the heaviest elements in the orbital plane and a direct view of any ultrarelativistic, highly collimated ejecta (a gamma-ray burst afterglow).
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| 6. |
- Franklin, Oskar, et al.
(författare)
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Organizing principles for vegetation dynamics
- 2020
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Ingår i: Nature plants. - : Springer Science and Business Media LLC. - 2055-026X .- 2055-0278. ; 6:5, s. 444-453
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Tidskriftsartikel (refereegranskat)abstract
- Plants and vegetation play a critical-but largely unpredictable-role in global environmental changes due to the multitude of contributing processes at widely different spatial and temporal scales. In this Perspective, we explore approaches to master this complexity and improve our ability to predict vegetation dynamics by explicitly taking account of principles that constrain plant and ecosystem behaviour: natural selection, self-organization and entropy maximization. These ideas are increasingly being used in vegetation models, but we argue that their full potential has yet to be realized. We demonstrate the power of natural selection-based optimality principles to predict photosynthetic and carbon allocation responses to multiple environmental drivers, as well as how individual plasticity leads to the predictable self-organization of forest canopies. We show how models of natural selection acting on a few key traits can generate realistic plant communities and how entropy maximization can identify the most probable outcomes of community dynamics in space- and time-varying environments. Finally, we present a roadmap indicating how these principles could be combined in a new generation of models with stronger theoretical foundations and an improved capacity to predict complex vegetation responses to environmental change. Integrating natural selection and other organizing principles into next-generation vegetation models could render them more theoretically sound and useful for earth system applications and modelling climate impacts.
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| 7. |
- Glasser, Neil F., et al.
(författare)
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Glacial lake drainage in Patagonia (13-8 kyr) and response of the adjacent Pacific Ocean
- 2016
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Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 6
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Tidskriftsartikel (refereegranskat)abstract
- Large freshwater lakes formed in North America and Europe during deglaciation following the Last Glacial Maximum. Rapid drainage of these lakes into the Oceans resulted in abrupt perturbations in climate, including the Younger Dryas and 8.2 kyr cooling events. In the mid-latitudes of the Southern Hemisphere major glacial lakes also formed and drained during deglaciation but little is known about the magnitude, organization and timing of these drainage events and their effect on regional climate. We use 16 new single-grain optically stimulated luminescence (OSL) dates to define three stages of rapid glacial lake drainage in the Lago General Carrera/Lago Buenos Aires and Lago Cohrane/Pueyrredon basins of Patagonia and provide the first assessment of the effects of lake drainage on the Pacific Ocean. Lake drainage occurred between 13 and 8 kyr ago and was initially gradual eastward into the Atlantic, then subsequently reorganized westward into the Pacific as new drainage routes opened up during Patagonian Ice Sheet deglaciation. Coupled ocean-atmosphere model experiments using HadCM3 with an imposed freshwater surface hosing to simulate glacial lake drainage suggest that a negative salinity anomaly was advected south around Cape Horn, resulting in brief but significant impacts on coastal ocean vertical mixing and regional climate.
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| 8. |
- Glasser, Neil F., et al.
(författare)
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Younger Dryas and early Holocene age glacier advances in Patagonia
- 2012
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Ingår i: Quaternary Science Reviews. - : Elsevier BV. - 0277-3791 .- 1873-457X. ; 58, s. 7-17
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Tidskriftsartikel (refereegranskat)abstract
- Reliable dating of Southern Hemisphere glacier fluctuations since the Last Glacial Maximum (LGM) is crucial to resolving debates about millennial-scale climate change. Here we present Be-10 dates for lateral, valley-mouth and cross-valley moraines formed between the contemporary South American North Patagonian Icefield (NPI) and its LGM position in four separate valleys around 47 degrees S. This is an area near the core of the precipitation-bearing southern westerly winds, where it is known that rapid shifts in climate occurred during Lateglacial times. The dates indicate that outlet glaciers advanced, or at least stabilised, to form large moraines east of an expanded NPI at 11.0 +/- 0.5/11.2 +/- 0.6, 11.5 +/- 0.6, 11.7 +/- 0.6 and 12.8 +/- 0.7 ka (Putnam southern-hemisphere production rates and Dunai scaling scheme, assumed boulder erosion rate of 2 mm/ka). Four of these ages are statistically indistinguishable and probably represent a single, regional ice advance. The dates indicate that glaciers in Patagonia were larger during these times than at any point since the LGM and provide evidence in Patagonia for glacier advances around the time of the European Younger Dryas (12.9-11.7 ka) and into the very early Holocene. Although palaeoclimatic records from this area are often contradictory, these glacier advances were probably associated with a period of cooling or regionally increased precipitation related to the changes in the position of the southern westerly winds.
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| 9. |
- Glasser, Neil, et al.
(författare)
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The glacial geomorphology and Pleistocene history of South America between 38 degrees S and 56 degrees S
- 2008
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Ingår i: QUATERNARY SCIENCE REVIEWS. - : Elsevier. - 0277-3791. ; 27:3-4, s. 365-390
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Tidskriftsartikel (refereegranskat)abstract
- This paper presents new mapping of the glacial geomorphology of southern South America between latitudes 38 degrees S and 56 degrees S, approximately the area covered by the former Patagonian Ice Sheets. Glacial geomorphological features, including glacial lineations, moraines, meltwater channels, trimlines, sandur and cirques, were mapped from remotely sensed images (Landsat 7 ETM +, pan-sharpened Landsat 7 and ASTER). The landform record indicates that the Patagonian Ice Sheets consisted of 66 main outlet glaciers, together with numerous local cirque glaciers and independent ice domes in the surrounding mountains. In the northern part of the mapped area, in the Chilean Lake District (38-42 degrees S), large piedmont glaciers developed on the western side of the Andes and the maximum positions of these outlet glaciers are, in general, marked by arcuate terminal moraines. To the east of the Andes between 38 degrees S and 42 degrees S, outlet glaciers were more restricted in extent and formed "alpine-style" valley glaciers. Along the eastern flank of the Andes south of similar to 45 degrees S a series of large fast-flowing outlet glaciers drained the ice sheet. The location of these outlet glaciers was topographically controlled and there was limited scope for interactions between individual lobes. West of the Andes at this latitude, there is geomorphological evidence for an independent ice cap close to sea level on the Taitao Peninsula. The age of this ice cap is unclear but it may represent evidence of glacier growth during the Antarctic Cold Reversal and/or Younger Dryas Chronozone. Maximum glacier positions are difficult to determine along much of the western side of the Andes south of 42 degrees S because of the limited land there, and it is assumed that most of these glaciers had marine termini. In the south-east of the mapped area, in the Fuegan Andes (Cordillera Darwin), the landform record provides evidence of ice-sheet initiation. By adding published dates for glacier advances from the literature we present maps of pre-Last Glacial Maximum (LGM) glacier extent, LGM extent and the positions of other large mapped moraines younger than LGM in age. A number of large moraines occur within the known LGM limits. The age of these moraines is unknown but, since many of them lie well outside the established maximum Neoglacial positions, the possibility that they reflect a return to glacial climates during the Younger Dryas Chronozone or Antarctic Cold Reversal cannot be discounted.
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