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- Dahlquist, Erik, 1951-, et al.
(författare)
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Experimental and numerical investigation of pellet and black liquor gasification for polygeneration plant
- 2017
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Ingår i: Applied Energy. - : Elsevier Ltd. - 0306-2619 .- 1872-9118. ; 204, s. 1055-1064
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Tidskriftsartikel (refereegranskat)abstract
- It is vital to perform system analysis on integrated biomass gasification in chemical recovery systems in pulp and paper and heat and power plants for polygeneration applications. The proposed integration complements existing pulp and paper and heat and power production systems with production of chemicals such as methane and hydrogen. The potential to introduce gasification-based combined cycles comprising gas turbines and steam turbines to utilize black liquors and wood pellets also merits investigation. To perform such analysis, it is important to first build knowledge on expected synthesis gas composition by gasifying at smaller scale different types of feed stock. In the present paper, the synthesis gas quality from wood pellets gasification has been compared with black liquor gasification by means of numerical simulation as well as through pilot-scale experimental investigations. The experimental results have been correlated into partial least squares models to predict the composition of the synthesis gas produced under different operating conditions. The gas quality prediction models are combined with physical models using a generic open-source modelling language for investigating the dynamic performance of large-scale integrated polygeneration plants. The analysis is further complemented by considering potential gas separation using modern membrane technology for upgrading the synthesis gas with respect to hydrogen content. The experimental data and statistical models presented in this study form an important literature source for future use by the gasification and polygeneration research community on further integrated system analysis.
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- Järås, Marcus, et al.
(författare)
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Csnk1a1 inhibition has p53-dependent therapeutic efficacy in acute myeloid leukemia
- 2014
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Ingår i: Journal of Experimental Medicine. - : Rockefeller University Press. - 1540-9538 .- 0022-1007. ; 211:4, s. 605-612
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Tidskriftsartikel (refereegranskat)abstract
- Despite extensive insights into the underlying genetics and biology of acute myeloid leukemia (AML), overall survival remains poor and new therapies are needed. We found that casein kinase 1 alpha (Csnk1a1), a serine-threonine kinase, is essential for AML cell survival in vivo. Normal hematopoietic stem and progenitor cells (HSPCs) were relatively less affected by shRNA-mediated knockdown of Csnk1a1. To identify downstream mediators of Csnk1a1 critical for leukemia cells, we performed an in vivo pooled shRNA screen and gene expression profiling. We found that Csnk1a1 knockdown results in decreased Rps6 phosphorylation, increased p53 activity, and myeloid differentiation. Consistent with these observations, p53-null leukemias were insensitive to Csnk1a1 knockdown. We further evaluated whether D4476, a casein kinase 1 inhibitor, would exhibit selective antileukemic effects. Treatment of leukemia stem cells (LSCs) with D4476 showed highly selective killing of LSCs over normal HSPCs. In summary, these findings demonstrate that Csnk1a1 inhibition causes reduced Rps6 phosphorylation and activation of p53, resulting in selective elimination of leukemia cells, revealing Csnk1a1 as a potential therapeutic target for the treatment of AML.
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- Kalantar-Zadeh, Kamyar, et al.
(författare)
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Nomenclature in nephrology : preserving renal and nephro in the glossary of kidney health and disease
- 2021
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Ingår i: JN. Journal of Nephrology. - : SPRINGER HEIDELBERG. - 1121-8428 .- 1724-6059. ; 34:3, s. 639-648
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Tidskriftsartikel (refereegranskat)abstract
- A recently published nomenclature by a "Kidney Disease Improving Global Outcomes" (KDIGO) Consensus Conference suggested that the word "kidney" should be used in medical writings instead of "renal" or "nephro" when referring to kidney disease and kidney health. Whereas the decade-old move to use "kidney" more frequently should be supported when communicating with the public-at-large, such as the World Kidney Day, or in English speaking countries in communications with patients, care-partners, and non-medical persons, our point of view is that "renal" or "nephro" should not be removed from scientific and technical writings. Instead, the terms can coexist and be used in their relevant contexts. Cardiologists use "heart" and "cardio" as appropriate such as "heart failure" and "cardiac care units" and have not replaced "cardiovascular" with "heartvessel", for instance. Likewise, in nephrology, we consider that "chronic kidney disease" and "continuous renal replacement therapy" should coexist. We suggest that in scientific writings and technical communications, the words "renal" and "nephro" and their derivatives are more appropriate and should be freely used without any pressure by medical journals to compel patients, care-partners, healthcare providers, researchers and other stakeholders to change their selected words and terminologies. We call to embrace the terms "kidney", "renal" and "nephro" as they are used in different contexts and ask that scientific and medical journals not impose terminology restrictions for kidney disease and kidney health. The choice should be at the discretion of the authors, in the different contexts including in scientific journals.
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