| 1. |
- Belmont, Anne-Sophie, et al.
(författare)
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Direct writing of molecularly imprinted microstructures using a nanofountain pen
- 2007
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Ingår i: Applied Physics Letters. - : AIP Publishing. - 0003-6951 .- 1077-3118. ; 90:19
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Tidskriftsartikel (refereegranskat)abstract
- Molecularly imprinted polymers (MIPs) constitute a very appealing avenue to parallel sensors of a multitude of small target molecules due to their stability, relative ease of preparation, and their ability to recognize targets for which natural capture molecules do not exist. The authors present here a way of arraying MIP structures with micrometer dimensions, using nanofountain pen, and demonstrate their functionality using a fluorescent template molecule. (C) 2007 American Institute of Physics.
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| 2. |
- Belmont, Anne-Sophie, et al.
(författare)
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Molecularly imprinted polymer films for reflectometric interference spectroscopic sensors
- 2007
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Ingår i: Biosensors & Bioelectronics. - : Elsevier BV. - 1873-4235 .- 0956-5663. ; 22:12, s. 3267-3272
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Tidskriftsartikel (refereegranskat)abstract
- Reflectometric interference spectroscopic measurements were performed on molecularly imprinted polymer (MIP) films with the herbicide atrazine as the template molecule. A conventional imprinting protocol was used relying on non-covalent interactions between the functional monomers and the template. The MIPs were deposited on glass transducers by two different methods: spin-coating followed by in situ polymerization of thin films of monomers containing a sacrificial polymeric porogen, and autoassembly of MIP nanoparticles with the aid of an associative linear polymer. Reproducible results were obtained upon measurements of atrazine solutions in toluene with both films. Atrazine concentrations as low as 1.7 pprn could be detected with the autoassembled particle film. No or very little analyte adsorption was observed onto non-imprinted control films made by spin-coating and by particle assembly, respectively. We believe that these MIP layers in combination with the general reflectrometric transduction scheme could be a versatile sensing tool for the detection of environmentally important and other analytes. (c) 2007 Elsevier B.V. All rights reserved.
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| 3. |
- Brüggemann, Oliver, et al.
(författare)
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New configurations and applications of molecularly imprinted polymers
- 2000
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Ingår i: Journal of Chromatography A. - 0021-9673. ; 889:1-2, s. 15-24
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Tidskriftsartikel (refereegranskat)abstract
- Molecularly imprinted polymers (MIPs) are applicable in a variety of different configurations. For example, bulk polymers imprinted with β-lactam antibiotics are presented to be used as stationary phases for the chromatographic separation of β-lactam antibiotics with both aqueous and organic mobile phases. However, in some analytical applications, monosized spherical beads are preferred over the currently used ground bulk polymers. A precipitation polymerization technique allows preparation of monosized spherical imprinted beads with diameters down to 200 nm having excellent recognition properties for different target molecules. Nevertheless, with current imprinting protocols a substantial amount of template has to be used to prepare the polymer. This can be problematic if the template is poorly soluble, expensive or difficult to obtain. It is shown that for analytical applications, the functional monomer:template ratio can be drastically increased without jeopardizing the polymer's recognition properties. Furthermore, a substantial reduction of the degree of crosslinking is demonstrated, resulting in much more flexible polymers that are useful for example the preparation of thin imprinted films and membranes for sensors. Apart from analysis, MIPs also are applicable in chemical or enzymatic synthesis. For example, MIPs using the product of an enzyme reaction as template are utilized for assisting the synthetic reaction by continuously removing the product from the bulk solution by complexation. This results in an equilibrium shift towards product formation. Copyright (C) 2000 Elsevier Science B.V.
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| 4. |
- Haupt, Karsten Olaf
(författare)
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Creating a good impression
- 2002
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Ingår i: Nature Biotechnology. - : Springer Science and Business Media LLC. - 1546-1696 .- 1087-0156. ; 20:9, s. 884-885
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 5. |
- Haupt, Karsten Olaf
(författare)
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Imprinted polymers - Tailor-made mimics of antibodies and receptors
- 2003
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Ingår i: Chemical Communications. - : Royal Society of Chemistry (RSC). - 1364-548X .- 1359-7345. ; :2, s. 171-178
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Tidskriftsartikel (refereegranskat)abstract
- The technique of molecular imprinting allows the formation of specific recognition sites in synthetic polymers through the use of templates or imprint molecules. These recognition sites mimic the binding sites of antibodies and other biological receptor molecules. Molecularly imprinted polymers can therefore be used in applications relying on specific molecular binding events. The stability, ease of preparation and low cost of these materials make them particularly attractive. This review focuses on recent developments and advances in the field of molecularly imprinted materials, with special emphasis on applications in immunoassays and sensors recently developed by our group and by others.
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| 6. |
- Mhaka, Byron, et al.
(författare)
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Selective extraction of triazine herbicides from food samples based on a combination of a liquid membrane and molecularly imprinted polymers
- 2009
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Ingår i: Journal of Chromatography A. - : Elsevier BV. - 0021-9673 .- 1873-3778. ; 1216:40, s. 6796-6801
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Tidskriftsartikel (refereegranskat)abstract
- A selective extraction technique based on the combination of liquid membrane (microporous membrane liquid-liquid extraction) and molecularly imprinted polymers (MIP) was applied to triazines herbicides in food samples. Simazine, atrazine and propazine were extracted from aqueous food samples through the hydrophobic porous membrane that was impregnated with toluene, which also formed part of the acceptor phase. In the acceptor phase, the compounds were re-extracted onto MIP particles. The extraction technique was optimised for the amount of molecularly imprinted polymers particles in the organic acceptor phase, extraction time, and type of organic acceptor solvent and desorption solvent. An extraction time of 90 min and 50 mg of MIP were found to be optimum parameters. Toluene as the acceptor phase was found to give higher triazines binding onto MIP particles compared to hexane and combinations of diethyl ether and hexane. 90% methanol in water was found to be the best desorption solvent compared to acetonitrile, methanol and water. The selectivity of the technique was demonstrated by extracting spiked lettuce and apple extracts where clean chromatograms were obtained compared to liquid membrane extraction alone or to the microporous membrane liquid-liquid extraction - non-imprinted polymer combination. The MIP showed a certain degree of group specificity and the extraction efficiency in lettuce extract was 79% (0.72) for simazine. 98% (1.55) for atrazine and 86% (3.08) for propazine.
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| 7. |
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| 8. |
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| 9. |
- Parlak, Onur, et al.
(författare)
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Light-triggered switchable graphene-polymer hybrid bioelectronics
- 2016
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Ingår i: Advanced Materials Interfaces. - : Wiley-VCH Verlagsgesellschaft. - 2196-7350. ; 3:2, s. 1500353-1-1500353-7
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Tidskriftsartikel (refereegranskat)abstract
- A light-switchable graphene interface to control and regulate electrobiocatalysis in a nanoconfined space is reported for the first time. The development of switchable and/or tunable interfaces on 2D nanosurfaces endowed with desirable functionalities, and incorporation of these interfaces into remote controlled biodevices, is a rapidly emerging area in bioelectronics.
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| 10. |
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