| 1. |
- Tabassum, R, et al.
(författare)
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Genetic architecture of human plasma lipidome and its link to cardiovascular disease
- 2019
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Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10:1, s. 4329-
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Tidskriftsartikel (refereegranskat)abstract
- Understanding genetic architecture of plasma lipidome could provide better insights into lipid metabolism and its link to cardiovascular diseases (CVDs). Here, we perform genome-wide association analyses of 141 lipid species (n = 2,181 individuals), followed by phenome-wide scans with 25 CVD related phenotypes (n = 511,700 individuals). We identify 35 lipid-species-associated loci (P <5 ×10−8), 10 of which associate with CVD risk including five new loci-COL5A1, GLTPD2, SPTLC3, MBOAT7 and GALNT16 (false discovery rate<0.05). We identify loci for lipid species that are shown to predict CVD e.g., SPTLC3 for CER(d18:1/24:1). We show that lipoprotein lipase (LPL) may more efficiently hydrolyze medium length triacylglycerides (TAGs) than others. Polyunsaturated lipids have highest heritability and genetic correlations, suggesting considerable genetic regulation at fatty acids levels. We find low genetic correlations between traditional lipids and lipid species. Our results show that lipidomic profiles capture information beyond traditional lipids and identify genetic variants modifying lipid levels and risk of CVD.
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| 2. |
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| 3. |
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| 4. |
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| 5. |
- Hautala, Lauri, et al.
(författare)
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Experimental observation of structural phase transition in CsBr clusters
- 2017
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Ingår i: Physical Review B. - 1098-0121. ; 95:4
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Tidskriftsartikel (refereegranskat)abstract
- Formation and growth of CsBr clusters embedded in unsupported Ar clusters was studied using synchrotron radiation photoelectron spectroscopy. The development of the core-level electronic structure for cluster sizes between a few and a few hundred atoms contained information about the local coordination of the constituent particles. The experimental results indicate that a gradual structural phase transition from NaCl structure to CsCl structure for CsBr clusters takes place at around 160 atoms per cluster.
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| 6. |
- Hautala, Lauri, et al.
(författare)
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Probing RbBr solvation in freestanding sub-2 nm water clusters
- 2017
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Ingår i: Physical Chemistry Chemical Physics. - : Royal Society of Chemistry (RSC). - 1463-9076 .- 1463-9084. ; 19:36, s. 25158-25167
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Tidskriftsartikel (refereegranskat)abstract
- Concentration dependent solvation of RbBr in freestanding sub-2 nm water clusters was studied using core level photoelectron spectroscopy with synchrotron radiation. Spectral features recorded from dilute to saturated clusters indicate that either solvent shared or contact ion pairs are present in increasing amount when the concentration exceeds 2 mol kg-1. For comparison, spectra from anhydrous RbBr clusters are also presented.
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| 8. |
- Koivikko, Niina, et al.
(författare)
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Activity and in situ DRIFT studies on vanadia catalysts during oxidative dehydrogenation of sulfur-contaminated methanol
- 2022
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Ingår i: Applied Catalysis B: Environmental. - : Elsevier BV. - 0926-3373. ; 318
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Tidskriftsartikel (refereegranskat)abstract
- Silica-titania (70/30) supported vanadium catalysts were prepared, characterized, and studied in oxidative dehydrogenation of sulfur-contaminated methanol. The quality of vanadia species is dependent on temperature and gas conditions during preparation, support type, support specific surface area and VOx surface density. For example, upon heating the amount of V2O5 decrease along with formation of polymeric species. Such changes may occur also during the catalytic reaction. The reaction experiments and characterization results showed that the stability of polymeric vanadia species and total acidity has a connection with better formaldehyde production performance. The best performance was observed for N2-calcined silica-titania catalyst. Easy reducibility of the catalyst, as in the case of reference catalysts, leads to further oxidation of formaldehyde.
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| 9. |
- Kokkonen, E., et al.
(författare)
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Fragmentation of mercury compounds under ultraviolet light irradiation
- 2015
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Ingår i: Journal of Chemical Physics. - : AIP Publishing. - 0021-9606 .- 1089-7690. ; 143:7
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Tidskriftsartikel (refereegranskat)abstract
- Ultraviolet light induced photofragmentation of mercury compounds is studied experimentally with electron energy resolved photoelectron-photoion coincidence techniques and theoretically with computational quantum chemical methods. A high resolution photoelectron spectrum using synchrotron radiation is presented. Fragmentation of the molecule is studied subsequent to ionization to the atomic-mercury-like d orbitals. State dependent fragmentation behaviour is presented and specific reactions for dissociation pathways are given. The fragmentation is found to differ distinctly in similar orbitals of different mercury compounds.
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