| 1. |
- Feigin, Valery L., et al.
(författare)
-
Global, regional, and national burden of stroke and its risk factors, 1990-2019 : a systematic analysis for the Global Burden of Disease Study 2019
- 2021
-
Ingår i: Lancet Neurology. - : Elsevier. - 1474-4422 .- 1474-4465. ; 20:10, s. 795-820
-
Tidskriftsartikel (refereegranskat)abstract
- Background Regularly updated data on stroke and its pathological types, including data on their incidence, prevalence, mortality, disability, risk factors, and epidemiological trends, are important for evidence-based stroke care planning and resource allocation. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) aims to provide a standardised and comprehensive measurement of these metrics at global, regional, and national levels. Methods We applied GBD 2019 analytical tools to calculate stroke incidence, prevalence, mortality, disability-adjusted life-years (DALYs), and the population attributable fraction (PAF) of DALYs (with corresponding 95% uncertainty intervals [UIs]) associated with 19 risk factors, for 204 countries and territories from 1990 to 2019. These estimates were provided for ischaemic stroke, intracerebral haemorrhage, subarachnoid haemorrhage, and all strokes combined, and stratified by sex, age group, and World Bank country income level. Findings In 2019, there were 12.2 million (95% UI 11.0-13.6) incident cases of stroke, 101 million (93.2-111) prevalent cases of stroke, 143 million (133-153) DALYs due to stroke, and 6.55 million (6.00-7.02) deaths from stroke. Globally, stroke remained the second-leading cause of death (11.6% [10.8-12.2] of total deaths) and the third-leading cause of death and disability combined (5.7% [5.1-6.2] of total DALYs) in 2019. From 1990 to 2019, the absolute number of incident strokes increased by 70.0% (67.0-73.0), prevalent strokes increased by 85.0% (83.0-88.0), deaths from stroke increased by 43.0% (31.0-55.0), and DALYs due to stroke increased by 32.0% (22.0-42.0). During the same period, age-standardised rates of stroke incidence decreased by 17.0% (15.0-18.0), mortality decreased by 36.0% (31.0-42.0), prevalence decreased by 6.0% (5.0-7.0), and DALYs decreased by 36.0% (31.0-42.0). However, among people younger than 70 years, prevalence rates increased by 22.0% (21.0-24.0) and incidence rates increased by 15.0% (12.0-18.0). In 2019, the age-standardised stroke-related mortality rate was 3.6 (3.5-3.8) times higher in the World Bank low-income group than in the World Bank high-income group, and the age-standardised stroke-related DALY rate was 3.7 (3.5-3.9) times higher in the low-income group than the high-income group. Ischaemic stroke constituted 62.4% of all incident strokes in 2019 (7.63 million [6.57-8.96]), while intracerebral haemorrhage constituted 27.9% (3.41 million [2.97-3.91]) and subarachnoid haemorrhage constituted 9.7% (1.18 million [1.01-1.39]). In 2019, the five leading risk factors for stroke were high systolic blood pressure (contributing to 79.6 million [67.7-90.8] DALYs or 55.5% [48.2-62.0] of total stroke DALYs), high body-mass index (34.9 million [22.3-48.6] DALYs or 24.3% [15.7-33.2]), high fasting plasma glucose (28.9 million [19.8-41.5] DALYs or 20.2% [13.8-29.1]), ambient particulate matter pollution (28.7 million [23.4-33.4] DALYs or 20.1% [16.6-23.0]), and smoking (25.3 million [22.6-28.2] DALYs or 17.6% [16.4-19.0]). Interpretation The annual number of strokes and deaths due to stroke increased substantially from 1990 to 2019, despite substantial reductions in age-standardised rates, particularly among people older than 70 years. The highest age-standardised stroke-related mortality and DALY rates were in the World Bank low-income group. The fastest-growing risk factor for stroke between 1990 and 2019 was high body-mass index. Without urgent implementation of effective primary prevention strategies, the stroke burden will probably continue to grow across the world, particularly in low-income countries.
|
|
| 2. |
- Hayat, Z., et al.
(författare)
-
A Novel Model-driven Framework for the Development of Web-based Geographical Information Systems
- 2023
-
Ingår i: Proceedings - 13th International Conference on Software Technology and Engineering, ICSTE 2023. - : IEEE. - 9798350371475 ; , s. 26-30
-
Konferensbidrag (refereegranskat)abstract
- Web-based Geographical Information Systems (Web-GIS) aim to store, analyze, and disseminate geospatial information, enabling effective decision-making. However, their development requires professional expertise and incurs high development costs, resulting in resource limitations for many organizations in developing their own GIS. To address these challenges, we propose a Geo-Location System (GLS) Framework with a Model-driven approach that will ease the developers to automatically develop their customized Web-GIS using Google Maps API. The framework incorporates a GLS meta-model encompassing essential concepts for Web-GIS development and proposes two novel features using OCL constraints to enhance the framework's capabilities. The framework also includes a customized tree editor and a graphical modeling tool that allows the easy modeling and visualization of any complex Web-GIS. Moreover, the framework provides an Acceleo transformation engine that automatically transforms models into executable Web code. The resulting source code is browser-ready without manual modifications. The proposed framework is validated with a real-world case study which demonstrates its effectiveness in reducing the overall development complexity, cost, and time.
|
|
| 3. |
- Kashif, Ahsan-Ullah, et al.
(författare)
-
A TCAD approach for non-linear evaluation of microwave power transistor and its experimental verification by LDMOS
- 2010
-
Ingår i: Journal of Computational Electronics. - : SpringerLink. - 1569-8025 .- 1572-8137. ; 9:2, s. 79-86
-
Tidskriftsartikel (refereegranskat)abstract
- A simulation technique is developed in TCAD to study the non-linear behavior of RF power transistor. The technique is based on semiconductor transport equations to swot up the overall non-linearity’s occurring in RF power transistor. Computational load-pull simulation technique (CLP) developed in our group, is further extended to study the non-linear effects inside the transistor structure by conventional two-tone RF signals, and initial simulations were done in time domain. The technique is helpful to detect, understand the phenomena and its mechanism which can be resolved and improve the transistor performance. By this technique, the third order intermodulation distortion (IMD3) was observed at different power levels. The technique was successfully implemented on a laterally-diffused field effect transistor (LDMOS). The value of IMD3 obtained is −22 dBc at 1-dB compression point (P 1 dB) while at 10 dB back off the value increases to −36 dBc. Simulation results were experimentally verified by fabricating a power amplifier with the similar LDMOS transistor.
|
|
| 4. |
- Kashif, Ahsan-Ullah, et al.
(författare)
-
A TCAD Approach to Design a Broadband Power Amplifier
- 2010
-
Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Technology Computer Aided Design (TCAD) provides an alternate method to study the power amplifier (PA) design prior to fabrication. It is very useful for the extraction of an accurate large signal model. This paper presents a design approach from device to circuit level to study broadband PA performance of RF-LDMOS using computational load-pull (CLP) analysis. To validate the TCAD approach, we have designed a broadband (1.9 - 2.5 GHz) class AB power amplifier. The concept is verified by designing an output broadband matching network at optimum impedance value (Zf) of RF-LDMOS using ADS software. The large signal results verify this concept and RF output power of 30.8 dBm is achieved with comparable gain and efficiency.
|
|
| 5. |
- Kashif, Ahsan-Ullah, et al.
(författare)
-
Switching Behavior of Microwave Power Transistor Studied in TCAD for Switching Class Power Amplifiers and Experimental Verification by LDMOS based Class-F Power Amplifier
- 2010
-
Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- This paper presents a TCAD study of high speed switching behavior of RF power-transistor in class-F Power Amplifier. We utilized finite harmonics loads for achieving maximum efficiency, without external circuitry. The in house developed computational load–pull (CLP) simulation technique is further extended to investigate the odd harmonic effects of RF transistor in class-F operation. An LD-MOSFET is studied which provided 81.2 % power added efficiency (PAE) at 1 GHz. The concept is experimentally verified by fabricating a class-F PA using same transistor. In the measurement, 76 % PAE is achieved, which is close to the TCAD simulated results. TCAD is an excellent tool to study the behavior of active devices. It has an ability to enhance and optimize the performance of transistor according to system specifications before fabrication.
|
|
| 6. |
- Shah, Said Nasir, et al.
(författare)
-
Bioactive, antioxidant and antimicrobial properties of chemically fingerprinted essential oils extracted from Eucalyptus globulus: in-vitro and in-silico investigations
- 2023
-
Ingår i: Frontiers in Chemistry. - : FRONTIERS MEDIA SA. - 2296-2646. ; 11
-
Tidskriftsartikel (refereegranskat)abstract
- Innovative approaches are urgently required to treat divestating bacterial diseases in the face of rising bacterial resistance rates. The current investigative work focused on hydro-distilling Tasmanian blue gum (Eucalyptus globulus) to isolate the essential oil, which was then tested for bioactivity, antioxidant capacity, and antibacterial activity using in-vitro and in silico assays. The antioxidant activity was avualated against DPPH and FRAP. With results of 69.63 RSA (%) (mu L/L AAE) at a concentration of 5 mL/L and 51.56 (mu L/L AAE) at concentration of 90 ppm in the 2,20-diphenyl-1-picryl hydrazyl (DPPH) and ferric reducing antioxidant power (FRAP) assays, respectively, the extracted oil indicated considerable antioxidant activity. The extracted oil demonstrated powerful antibacterial activity in in-vitro tests against both Gram-positive and Gram-negative bacterial strains, including Bordetella bronchiseptica (21 mm), Staphylococcus epidermidis (19 mm), and Staphylococcus aureus (19 mm), with significant minimal inhibitory (MIC) and minimum bactericidal (MIB) concentrations. Additionally, GC-MS analysis of the oil from E. globulus identified several low-molecular-weight compounds, including Eucalyptol, gamma-Terpinene, Shisool acetate, 1,3-trans,5-cis-Octatriene, 2,6-Dimethyl-1,3,5,7-octatetraene, E,E, Cyclohexene, 1-methyl-4-(1-methylethylidene), Benzene, 1-methyl-4-(1-methylethenyl), Butanoic acid, 3-methyl-, 3-methylbutyl ester, and 1,3,8-p-Menthatriene. Several other compounds were also identified, including Fenchol, 2-Methyl-trans-3a,4,7,7a-tetrahydroindane, (E,E,E)-2,4,6-Octatriene, 1,2,3,6-Tetrahydrobenzylalcohol, acetate, Alloaromadendrene, Phenol, 2-ethyl-4,5-dimethyl, Phenol, 2-methyl-5-(1-methylethyl)-, p-Cymen-7-ol, 1,5,5-Trimethyl-6-methylene-cyclohexene, 1,3-Cyclohexadiene, 1-methyl-4-(1-methylethyl)-, 2,6-Octadien-1-ol, 3,7-dimethyl-, acetate, (Z), and more. The bioactive potential of Eucalyptus globulus essential oil against 1AJ6 and 1R4U was highlighted by molecular docking analyses, suggesting its utility as a natural source of antioxidant and antibacterial compounds with the potential to replace chemical disinfectants in a variety of applications.
|
|
