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- Ramilowski, JA, et al.
(författare)
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Functional annotation of human long noncoding RNAs via molecular phenotyping
- 2020
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Ingår i: Genome research. - : Cold Spring Harbor Laboratory. - 1549-5469 .- 1088-9051. ; 30:7, s. 1060-1072
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Tidskriftsartikel (refereegranskat)abstract
- Long noncoding RNAs (lncRNAs) constitute the majority of transcripts in the mammalian genomes, and yet, their functions remain largely unknown. As part of the FANTOM6 project, we systematically knocked down the expression of 285 lncRNAs in human dermal fibroblasts and quantified cellular growth, morphological changes, and transcriptomic responses using Capped Analysis of Gene Expression (CAGE). Antisense oligonucleotides targeting the same lncRNAs exhibited global concordance, and the molecular phenotype, measured by CAGE, recapitulated the observed cellular phenotypes while providing additional insights on the affected genes and pathways. Here, we disseminate the largest-to-date lncRNA knockdown data set with molecular phenotyping (over 1000 CAGE deep-sequencing libraries) for further exploration and highlight functional roles for ZNF213-AS1 and lnc-KHDC3L-2.
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- Hayatsu, K., et al.
(författare)
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Lunar radiation dose due to cosmic rays and their secondary particles
- 2010
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Ingår i: 61st International Astronautical Congress 2010, IAC 2010.Prague, 27 September-1 October 2010. - 9781617823688 ; 5, s. 4084-4088
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Konferensbidrag (refereegranskat)abstract
- To be able to safely perform human activities on the lunar surface, it is very important to assess the radiation environment, including the dose from galactic cosmic Rays (GCRs) and large Solar Energetic Particles (SEPs). Especially, large SPEs are highly hazardous to lunar habitants. In this paper, several SPEs have been evaluated in order to estimate the effective dose equivalent on the lunar surface. Several events give more than 1 Sv without any shield.
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