| 1. |
- Rosenhall, Ulf, et al.
(författare)
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Dietary habits and hearing
- 2015
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Ingår i: International Journal of Audiology. - 1499-2027 .- 1708-8186. ; 54:Suppl. 1, s. S53-S56
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Tidskriftsartikel (refereegranskat)abstract
- Objective: Study groups from three age cohorts of 70-75 year-olds were investigated to search for possible correlations between dietary habits and auditory function.Design: A cross-sectional, epidemiological study.Study sample: A total number of 524 people (275 women, 249 men) were recruited from three age cohorts. The study sample was representative of the general population. All participants answered a diet history and were tested with pure-tone audiometry. Eleven categories of food consumption were related to pure-tone averages of low-mid frequency hearing, and high frequency hearing.Results: Two consistent correlations between diet and hearing were observed. One was a correlation between good hearing and a high consumption of fish in the male group. The other was a correlation between poor high frequency hearing and a high consumption of food rich in low molecular carbohydrates in both genders; a larger effect size was seen in females.Conclusions: The study indicates that diet is important for aural health in aging. According to this study fish is beneficial to hearing, whereas consumption of "junk food", rich in low molecular carbohydrates, is detrimental. Other correlations, e.g. between high consumption of antioxidants, were not demonstrated here, but cannot be excluded.
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| 2. |
- Hederstierna, Christina Forshell
(författare)
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Hearing in menopausal women and in women with Turner syndrome : a model for hearing matured in an estrogen-deficient environment
- 2009
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Epidemiological studies have shown that women have better high-frequency hearing than men in virtually all age groups, regardless of noise-exposure, and that agerelated hearing decline starts after age 30 in men but not until after the age of 50 in women. This coincides with the menopausal transition in most women, thus leading us to hypothesize that the menopause triggers auditory deterioration. This may be due to reduced levels of endogenous circulating estrogens, which are known to have protective effects on the auditory system. Turner syndrome is a chromosomal aberration affecting 1:2000 newborn girls, in which all or part of one X chromosome is absent. This leads to ovarian dysgenesis and little or no endogenous estrogen production. These women have, among many other syndromal features, a high occurrence of ear and hearing problems, and neurocognitive dysfunctions, including reduced visual-spatial abilities. It is assumed that estrogen deficiency is at least partially responsible for these problems. One objective of this thesis was to describe the prevalence of hearing loss and to classify audiometric configurations in a group of 143 healthy middle-aged women in the general population with respect to menopausal stage and hormone replacement therapy (HRT). A follow-up study including 101 of these women was performed 7.5 years later to describe the rate of hearing decline during the menopausal transition. Another objective was to perform a battery of hearing tests in a group of 30 adult women with Turner syndrome (TS), aimed at localizing the lesion causing the sensorineural hearing impairment and assessing central auditory function, primarily sound localization. Further we carried out a longitudinal study of hearing thresholds in a group of 69 TS women to determine whether the factors initial age, initial hearing level, karyotype, and presence/absence of a mid-frequency dip influences the rate of decline and could serve as prognostic markers. The main findings in middle-aged women in the general population are that although they have close to normal median hearing thresholds, a large proportion has significant high-frequency losses and dips, which are overlooked if only an average of thresholds at 0.5-4 kHz is used to determine prevalence of hearing impairment. Further, the menopause per se seems to be the starting point for an accelerated period of hearing decline, rather than age alone. In TS women we showed that cochlear dysfunction is the major cause for the sensorineural impairment. Phase audiometry, a test for sound localization, showed mild disturbances in the TS women compared to the reference group, suggesting that auditory-spatial dysfunction is another facet of the recognized neurocognitive phenotype in TS. Further, the rate of hearing decline in women with TS is comparable to that seen in 70-90-year-old women in the general population, regardless of initial age, hearing level, karyotype, or presence of a mid-frequency dip. The presence of a mid-frequency dip is an especially strong predictor for a future high rate of highfrequency hearing decline with subsequent social consequences.
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| 3. |
- Hederstierna, Christina, et al.
(författare)
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The prevalence of Connexin 26 mutations in the Swedish population
- 2005
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Ingår i: Audiological Medicine. - : Informa Healthcare. - 1651-386X .- 1651-3835. ; 3:3, s. 154-158
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Tidskriftsartikel (refereegranskat)abstract
- Mutations in GJB2, the gene encoding the protein Connexin 26, have been shown to account for as much as 50% of autosomal recessive, non-syndromic childhood hearing loss (ARNSHL). Early, correct diagnosis and intervention have greatly improved the possibilities for these children in learning and developing language skills. In recent years, many reports from varied parts of the world have described the local scene of mutations in Connexin 26. The prevalence differs with geographic location and assessment procedures. Mutations in Connexin 26 have until recently been identified in very few cases in Sweden, Norway and Denmark, and nationwide population samples have not been studied in the Scandinavian countries. In this study we present the results of a large nationwide and a regional study of the prevalence of the 35delG, L90P and 167delT mutations of the GJB2 gene in Sweden. A total of 2052 samples (dried blood spots) were analysed. 1501 samples were collected representing all of Sweden and 551 samples from northern Sweden. The allele frequencies in Sweden were found to be 35delG, 0.83%; L90P, 0.30%; and 167delT, 0%. The prevalence of mutations in Connexin 26 in Sweden seems to be comparable to that in other northern European countries.
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| 4. |
- Idrizbegovic, Esma, et al.
(författare)
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Central auditory function in early Alzheimer's disease and in mild cognitive impairment.
- 2011
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Ingår i: Age and Ageing. - : Oxford University Press (OUP). - 0002-0729 .- 1468-2834. ; 40:2
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: to investigate auditory function in subjects with early Alzheimer's disease, mild cognitive impairment and with subjective memory complaints, in search of signs of central auditory processing dysfunction even in early stages of cognitive impairment.DESIGN AND SUBJECTS: a consecutive group of men and women, referred to the Memory Clinic at the Karolinska University Hospital, was approached for inclusion in this prospective study. One hundred and thirty-six subjects, mean age 64 years (range 50-78 years), diagnosed with Alzheimer's disease (n = 43), mild cognitive impairment (n = 59) or with subjective memory complaints (n = 34), were included.METHODS: auditory function was assessed with pure tone audiometry, speech perception in quiet and in background noise and dichotic digits tests with two or three digits.RESULTS: pure tone audiometry and speech perception scores in quiet and in background noise were normal for age and without between-group differences. Dichotic digits tests showed strongly significant differences between the three groups, where the Alzheimer's disease group performed significantly poorer than the other two groups, with the mild cognitive impairment group in an intermediate position.CONCLUSIONS: our results demonstrate that central auditory processing dysfunction is highly evident in subjects with Alzheimer's disease, and to a considerable extent even in subjects with mild cognitive impairment.
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| 5. |
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| 6. |
- Rosenhall, Ulf, et al.
(författare)
-
Dietary habits and hearing
- 2014
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- The infl uence on the hearing of micronutrients has been studied in both humans and research animals. Vitamin intake and diets with supplementation of one or more micronutrient have been studied. In a Swedish epidemiological investigation (the Gerontological and Geriatric Population Study in Gothenburg) nutrient and food intake of 70-year old persons from three age cohorts was studied. The results of a comparison between a dietary enquiry and pure tone audiometry will be presented and discussed.
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| 7. |
- Rosenhall, Ulf, et al.
(författare)
-
Dietary habits and hearing
- 2015
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Ingår i: International Journal of Audiology. - : Taylor and Francis Ltd.. - 1499-2027 .- 1708-8186. ; 54:Suppl. 1, s. S53-S56
-
Tidskriftsartikel (refereegranskat)abstract
- Objective: Study groups from three age cohorts of 70-75 year-olds were investigated to search for possible correlations between dietary habits and auditory function. Design: A cross-sectional, epidemiological study. Study sample: A total number of 524 people (275 women, 249 men) were recruited from three age cohorts. The study sample was representative of the general population. All participants answered a diet history and were tested with pure-tone audiometry. Eleven categories of food consumption were related to pure-tone averages of low-mid frequency hearing, and high frequency hearing. Results: Two consistent correlations between diet and hearing were observed. One was a correlation between good hearing and a high consumption of fish in the male group. The other was a correlation between poor high frequency hearing and a high consumption of food rich in low molecular carbohydrates in both genders; a larger effect size was seen in females. Conclusions: The study indicates that diet is important for aural health in aging. According to this study fish is beneficial to hearing, whereas consumption of "junk food", rich in low molecular carbohydrates, is detrimental. Other correlations, e.g. between high consumption of antioxidants, were not demonstrated here, but cannot be excluded.
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| 8. |
- Rosenhall, Ulf, et al.
(författare)
-
Dietary habits and hearing
- 2014
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- The infl uence on the hearing of micronutrients has been studied in both humans and research animals. Vitamin intake and diets with supplementation of one or more micronutrient have been studied. In a Swedish epidemiological investigation (the Gerontological and Geriatric Population Study in Gothenburg) nutrient and food intake of 70-year old persons from three age cohorts was studied. The results of a comparison between a dietary enquiry and pure tone audiometry will be presented and discussed.
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| 9. |
- Rosenhall, Ulf, et al.
(författare)
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Hearing of 75-year old persons over three decades : Has hearing changed?
- 2013
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Ingår i: International Journal of Audiology. - : Informa UK Limited. - 1499-2027 .- 1708-8186. ; 52:11, s. 731-739
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Tidskriftsartikel (refereegranskat)abstract
- Objective: The state of hearing in 75-year old persons was measured in a population based epidemiological study with the aim of studying if hearing had changed during a time span of 29 years. Design: An epidemiological study of generational effects in three age cohorts. Study sample: Three age cohorts were included: cohort 1 (n: 267) born in 1976-77, cohort 4 (n: 197) in 1990-91, and cohort 6 (n: 570) in 2005. The same test procedures using pure-tone audiometry and a short questionnaire were applied to the three cohorts of 75-year old residents in the same city. Results: The hearing was essentially unchanged during the span of the investigation-almost three decades. Low-frequency hearing was up to about 10 dB poorer in the most recently studied cohort compared to the previously studied cohorts. The reason for this difference is considered to depend on methodological factors. Self-assessed hearing and tinnitus was mainly unchanged, or had minor changes both to the better and to the worse. Conclusions: The hearing, both measured with pure-tone audiometry and with a short questionnaire, of 75-year old persons has not changed at all, or only marginally, over three decades.
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