| 1. |
- Adman, Per, et al.
(författare)
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171 forskare: ”Vi vuxna bör också klimatprotestera”
- 2019
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Ingår i: Dagens nyheter (DN debatt). - Stockholm. - 1101-2447.
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- DN DEBATT 26/9. Vuxna bör följa uppmaningen från ungdomarna i Fridays for future-rörelsen och protestera eftersom det politiska ledarskapet är otillräckligt. Omfattande och långvariga påtryckningar från hela samhället behövs för att få de politiskt ansvariga att utöva det ledarskap som klimatkrisen kräver, skriver 171 forskare i samhällsvetenskap och humaniora.
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| 2. |
- Danielsson, Axel, et al.
(författare)
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Transmission of hepatitis C virus among intravenous drug users in the Uppsala region of Sweden
- 2014
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Ingår i: Infection Ecology & Epidemiology. - : Informa UK Limited. - 2000-8686. ; 4
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Epidemiology and transmission patterns of hepatitis C virus (HCV) are important subjects as we enter a new era of treatment with directly acting antivirals (DAAs). The highest prevalence of HCV in developed countries is found among intravenous drug users (IDUs), where unsafe needle sharing practices provide the main route of infection. Efforts to prohibit the continuous spread of HCV among these groups have been initiated by the community services and health care providers. Our goal was to understand how HCV was transmitted among IDUs within a limited population group. We provide a retrospective study (2005-2007) of the HCV transmission patterns in a population of IDUs in the Uppsala region of Sweden.METHOD: Eighty-two serum samples were collected from IDUs in Uppsala County. Our reverse transcription nested polymerase chain reaction (RT-nested PCR) and sequencing method enabled a comprehensive genetic analysis for a broad spectrum of genotypes of two relatively conserved regions, NS5B and NS3, that encodes for the viral polymerase and protease, respectively. HCV RNA in serum samples was amplified and sequenced with in-house primers. Sequence similarities between individuals and subgroups were analyzed with maximum likelihood (ML) phylogenetic trees. Published HCV reference sequences from other geographic regions and countries were also included for clarity.RESULTS: Phylogenetic analysis was possible for 59 NS5B (72%) and 29 NS3 (35%) sequences from Uppsala patients. Additionally, we also included 15 NS3 sequences from Örebro patients, making a total of 44 NS3 sequences for the analysis. By analyzing the NS3 sequences, two transmission sets were found between the IDUs (>98% sequence identity), with one set consisting of two individuals and another set consisting of three individuals. In addition, the phylogenetic analysis done with our serum samples displayed clusters that distinguished them from the reference sequences.CONCLUSION: Our method seems to enable us to trace the HCV transmission between IDUs. Furthermore, the method is fairly independent of the time of infection because the method uses relatively conserved HCV sequence regions (i.e. NS5B and NS3).
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| 3. |
- Eriksson, Hanna, et al.
(författare)
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Quantitative membrane proteomics applying narrow range peptide isoelectric focusing for studies of small cell lung cancer resistance mechanisms
- 2008
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Ingår i: Proteomics. - : Wiley. - 1615-9853 .- 1615-9861. ; 28:5C, s. 3275-3276
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Tidskriftsartikel (refereegranskat)abstract
- Drug resistance is often associated with upregulation of membrane-associated drug-efflux systems, and thus global membrane proteomics methods are valuable tools in the search for novel components of drug resistance phenotypes. Herein we have compared the microsomal proteome from the lung cancer cell line H69 and its isogenic Doxorubicin-resistant subcell line H69AR. The method used includes microsome preparation, iTRAQ labeling followed by narrow range peptide IEF in an immobilized pH-gradient (IPG-IEF) and LC-MS/MS analysis. We demonstrate that the microsomal preparation and iTRAQ labeling is reproducible regarding protein content and composition. The rationale using narrow range peptide IPG-IEF separation is demonstrated by its ability to: (i) lowering the complexity of the sample by two-thirds while keeping high proteome coverage (96%), (ii) providing high separation efficiency, and (iii) allowing for peptide validation and possibly identifications of post-transcriptional modifications. After analyzing one-fifth of the IEF fractions (effective pH range of 4.0-4.5), a total of 3704 proteins were identified, among which 527 were predicted to be membrane proteins. One of the proteins found to be differentially expressed was Serca 2, a calcium pump located in the ER membrane that potentially could result in changes of apoptotic response toward Doxorubicin.
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| 4. |
- Hedlund, Magnus, 1986-, et al.
(författare)
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Eddy Currents in a Passive Magnetic Axial Thrust Bearing for a Flywheel Energy Storage System
- 2017
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Ingår i: International journal of applied electromagnetics and mechanics. - 1383-5416 .- 1875-8800. ; 54:3, s. 389-404
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Tidskriftsartikel (refereegranskat)abstract
- Two types of passive magnetic lift bearings were evaluated in terms of thrust force and eddy current losses. The first type of bearings were based on two sets of segmented Halbach arrays mounted in repulsive mode, and the second type was based on ring-magnets. The eddy-currents studied arose in the bearing due to manufacturing variations of magnetic remanence, and due to non-radial magnetization. Both a 3D time-dependent and a quasi-stationary Finite-Element Method (FEM) formulation were used, and the simulated results were compared with lift-force measurements from experiment. The losses were found (by FEM) to be in the order of 25 W at a rotational speed of 30000 rpm while lifting a 45 kg rotor with a stiffness of 359 N/mm.
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| 5. |
- Hedlund, Magnus, 1986-, et al.
(författare)
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Flywheel Energy Storage for Automotive Applications
- 2015
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Ingår i: Energies. - : MDPI AG. - 1996-1073. ; 8:10, s. 10636-10663
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Forskningsöversikt (refereegranskat)abstract
- A review of flywheel energy storage technology was made, with a special focus on the progress in automotive applications. We found that there are at least 26 university research groups and 27 companies contributing to flywheel technology development. Flywheels are seen to excel in high-power applications, placing them closer in functionality to supercapacitors than to batteries. Examples of flywheels optimized for vehicular applications were found with a specific power of 5.5 kW/kg and a specific energy of 3.5 Wh/kg. Another flywheel system had 3.15 kW/kg and 6.4 Wh/kg, which can be compared to a state-of-the-art supercapacitor vehicular system with 1.7 kW/kg and 2.3 Wh/kg, respectively. Flywheel energy storage is reaching maturity, with 500 flywheel power buffer systems being deployed for London buses (resulting in fuel savings of over 20%), 400 flywheels in operation for grid frequency regulation and many hundreds more installed for uninterruptible power supply (UPS) applications. The industry estimates the mass-production cost of a specific consumer-car flywheel system to be 2000 USD. For regular cars, this system has been shown to save 35% fuel in the U.S. Federal Test Procedure (FTP) drive cycle.
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| 6. |
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| 7. |
- Jakobsson, Johan, et al.
(författare)
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Effects and mechanisms of supramaximal High-Intensity Interval Training on extrapulmonary manifestations in people with and without Chronic Obstructive Pulmonary Disease (COPD-HIIT) : study protocol for a multi-centre, randomized controlled trial
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Background: Beyond being a pulmonary disease, chronic obstructive pulmonary disease (COPD) presents with extrapulmonary manifestations including reduced cognitive, cardiovascular, and muscle function. While exercise training is the cornerstone in the non-pharmacological treatment of COPD, there is a need for new exercise training methods due to suboptimal adaptations when following traditional exercise guidelines, often applying moderate-intensity continuous training (MICT). In people with COPD, short-duration high-intensity interval training (HIIT) holds the potential to induce a more optimal stimulus for training adaptations while circumventing the ventilatory burden often associated with MICT in people with COPD. We aim to determine the effects of supramaximal HIIT and MICT on extrapulmonary manifestations in people with COPD compared to matched healthy controls.Methods: COPD-HIIT is a prospective, multi-centre, randomised, controlled trial with blinded assessors and data analysts, employing a parallel-group trial. In Phase 1, we will investigate the effects and mechanisms of a 12-week intervention of supramaximal HIIT compared to MICT in people with COPD (n = 92) and matched healthy controls (n = 70). Participants will perform watt-based cycling 2–3 times weekly. In Phase 2, we will determine how exercise training and inflammation impact the trajectories of neurodegeneration, in people with COPD, over 24 months. In addition to the 92 participants with COPD performing HIIT or MICT, a usual care group (n = 46) is included in phase 2. In both phases, the primary outcomes are change from baseline in cognitive function, cardiorespiratory fitness, and muscle power. Key secondary outcomes include change from baseline exercise tolerance, brain structure and function measured by MRI, neuroinflammation measured by PET/CT, systemic inflammation, and intramuscular adaptations. Feasibility of the interventions will be comprehensively investigated.Discussion: The COPD-HIIT trial will determine the effects of supramaximal HIIT compared to MICT in people with COPD and healthy controls. We will provide evidence for a novel exercise modality that might overcome the barriers associated with MICT in people with COPD. We will also shed light on the impact of exercise at different intensities to reduce neurodegeneration. The goal of the COPD-HIIT trial is to improve the treatment of extrapulmonary manifestations of the disease.Trial registration: Clinicaltrials.gov: NCT06068322. Prospectively registered on 2023-09-28.
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| 8. |
- Köhler, Johan, et al.
(författare)
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A hybrid cold gas microthruster system for spacecraft
- 2001
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Ingår i: Digest of Papers for the 11th Int Conf on Solid-State Sensors and Actuators - Transducers '01 and Eurosensors XV, Munich, Germany, June 10-14. ; , s. 886-889
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Konferensbidrag (refereegranskat)
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| 9. |
- Lindholm, Carl-Johan, et al.
(författare)
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Experimental analysis of stresses in curved sandwich structures
- 2015
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Ingår i: 20th International Conference on Composite Materials.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Some studies indicate that the cross-section of large wind turbine blades subjected to wind and gravity loads will ovalise due to the Brazier effects [1,2]. This feature could however not be verified by numerical experiments of a FE model of a fictive 61.5 m blade, based on the NREL 5MW reference turbine [3], subjected to simplified load cases. Accurate prediction of failure modes of sandwich structures based on finite element calculations are highly important if accurate predictions of such features in large wind turbine blades are to be investigated.In this study, an experimental setup designed to cause deflection and stress patterns in the core similar to what might be achieved by the Brazier effect in a wind turbine blade subjected to severe wind loads has been carried out. The test set up will highlight stress in the through-thickness direction, causing classical shell theory to be circumspect as a modelling tool. By designing specimens with different foam core material properties, stiffness and strength, different failure modes were observed in the test. Through the use of combinations of solid and shell elements and geometrically nonlinear analyses, the experimental effects were shown to be predictable by an otherwise linear FE model.
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| 10. |
- Lindholm, Carl-Johan, et al.
(författare)
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Experimental analysis of stresses in sandwich structures due to the brazier effect
- 2015
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Ingår i: ICCM International Conferences on Composite Materials. ; 2015-July
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Konferensbidrag (refereegranskat)abstract
- © 2015 International Committee on Composite Materials. All rights reserved. Some studies indicate that the cross-section of large wind turbine blades subjected to wind and gravity loads will ovalise due to the Brazier effects [1,2]. This feature could however not be verified by numerical experiments of a FE model of a fictive 61.5 m blade, based on the NREL 5MW reference turbine [3], subjected to simplified load cases. Accurate prediction of failure modes of sandwich structures based on finite element calculations are highly important if accurate predictions of such features in large wind turbine blades are to be investigated. In this study, an experimental setup designed to cause deflection and stress patterns in the core similar to what might be achieved by the Brazier effect in a wind turbine blade subjected to severe wind loads has been carried out. The test set up will highlight stress in the through-thickness direction, causing classical shell theory to be circumspect as a modelling tool. By designing specimens with different foam core material properties, stiffness and strength, different failure modes were observed in the test. Through the use of combinations of solid and shell elements and geometrically nonlinear analyses, the experimental effects were shown to be predictable by an otherwise linear FE model.
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