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- Heffernan, Megan, et al.
(författare)
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Sex and gender publications in brain health : a mapping review of the Asia-Pacific region
- 2024
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Ingår i: Cerebrovascular Diseases. - 1421-9786.
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Tidskriftsartikel (refereegranskat)abstract
- INTRODUCTION: Reporting of sex and gender analysis in medical research has been shown to improve quality of the science and ensures findings are applicable to women and men. There is conflicting evidence on whether efforts by funding agencies and medical journals to encourage reporting of sex and gender analysis has resulted in tangible improvements. This study mapped the inclusion of sex and gender analysis in stroke and dementia research conducted in the Asia-Pacific region.METHODS: A systematic search for Asia-Pacific stroke and dementia research was conducted in PubMed and papers included from the period 2012 to 2022. Eligible studies were reviewed for inclusion of a primary sex or gender focus and categorized by type of sex and gender analysis. Author gender was determined using an algorithm and its associations with inclusion of sex and gender analysis examined.RESULTS: Total Asia-Pacific publications increased from 109 in 2012 to 313 in 2022, but the rate of studies with a primary sex or gender focus did not increase significantly (R2 = 0.06, F(1,9) = 0.59, p = 0.46). Australia, China, India, Japan and South Korea produced the most publications over the study period and were the only countries with at least 50 publications. The impact of author gender was mixed, with female first authorship associated with inclusion of sex or gender analysis and last female authorship associated with studies having a primary sex or gender focus.CONCLUSIONS: In the Asia-Pacific, brain health research is currently centered around high income countries and efforts are needed to ensure research findings are applicable through out the region. While there was a general increase in brain health publications over the last decade, the rate of sex and gender analysis was unchanged. This demonstrates that even with efforts in some countries in place, there is currently a lack of progress in the Asia-Pacific region to produce more research focusing on sex and gender analysis.
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| 2. |
- Kivipelto, Miia, et al.
(författare)
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World-Wide FINGERS Network : A global approach to risk reduction and prevention of dementia
- 2020
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Ingår i: Alzheimer's & Dementia. - : Wiley. - 1552-5260 .- 1552-5279. ; 16:7, s. 1078-1094
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Tidskriftsartikel (refereegranskat)abstract
- Reducing the risk of dementia can halt the worldwide increase of affected people. The multifactorial and heterogeneous nature of late-onset dementia, including Alzheimer's disease (AD), indicates a potential impact of multidomain lifestyle interventions on risk reduction. The positive results of the landmark multidomain Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) support such an approach. The World-Wide FINGERS (WW-FINGERS), launched in 2017 and including over 25 countries, is the first global network of multidomain lifestyle intervention trials for dementia risk reduction and prevention. WW-FINGERS aims to adapt, test, and optimize the FINGER model to reduce risk across the spectrum of cognitive decline-from at-risk asymptomatic states to early symptomatic stages-in different geographical, cultural, and economic settings. WW-FINGERS aims to harmonize and adapt multidomain interventions across various countries and settings, to facilitate data sharing and analysis across studies, and to promote international joint initiatives to identify globally implementable and effective preventive strategies.
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| 3. |
- Kuhn, McKenzie A., et al.
(författare)
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High ebullitive, millennial-aged greenhouse gas emissions from thermokarst expansion of peatland lakes in boreal western Canada
- 2023
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Ingår i: Limnology and Oceanography. - : Association for the Sciences of Limnology and Oceanography. - 0024-3590 .- 1939-5590. ; 68:2, s. 498-513
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Tidskriftsartikel (refereegranskat)abstract
- Methane (CH4) and carbon dioxide (CO2) emissions from small peatland lakes may be highly sensitive to climate warming and thermokarst expansion caused by permafrost thaw. We studied effects of thermokarst expansion on ebullitive CH4 and CO2 fluxes and diffusive CH4 fluxes from a peatland thaw lake in boreal western Canada. Ebullitive CH4 fluxes from the thaw edge (236 ± 61 mg CH4 m−2 d−1) were double and quadruple that of the stable lake edge and center, respectively. Modeled diffusive CH4 fluxes did not differ between the thawing and stable edges (~ 50 mg CH4 m−2 d−1) but were double that of the center. Radiocarbon (14C) analysis of CH4 and CO2 bubbles from the thaw edge was older (~ 1211 and 1420 14C yr BP) than from the stable edge and the center (modern to ~ 102 and 50 14C yr BP, respectively). Incubations indicated that deep, old peat sediment was more labile along the thaw edge than in the center. While our study suggested increase CH4 emissions partly derived from millennial-aged carbon along the thaw edge, accounting for these emissions only increased the estimated total lake CH4 emissions by ~ 10%, which is a much smaller contribution than measured from thermokarst lakes in yedoma regions. Our study suggests that it is important to account for landscape history and lake types when studying the processes that govern the sensitivity of lake greenhouse gas emissions to climate change.
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