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| 2. |
- Hegyesi, G., et al.
(author)
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Development of an FPGA-based data acquisition module for small animal PET
- 2004
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In: 2004 IEEE Nuclear Science Symposium Conference Record. - 0780387007 ; , s. 2957-2961
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Conference paper (peer-reviewed)abstract
- We report on the design of a DAQ module for a small animal PET camera developed at our institutes. During the design an important guideline was to develop a system which is built up from strictly identical DAQ modules, and which has no built-in hardware limitation on the maximum number of modules. The developed DAQ module comprises of an LSO scintillator crystal block, a position sensitive PMT, analog signal conditioning circuits, a digitizer, an FPGA for digital signal processing and a communication module through which the collected data is sent to a cluster of computers for post processing and storage. Instead of implementing hardware coincidence detection between the modules we attach a precise time-stamp to each event in our design, and the coincidence is determined by the data collecting computers during the post processing. The digital CFD algorithm implemented in the FPGA gives a time resolution of 2 to 3 ns FWHM for real detector signals.
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| 3. |
- Hegyesi, G., et al.
(author)
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Ethernet based distributed data acquisition system for a small animal PET
- 2006
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In: IEEE Transactions on Nuclear Science. - 0018-9499 .- 1558-1578. ; 53:4, s. 2112-2117
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Journal article (peer-reviewed)abstract
- We report on the design of a small animal PET scanner being developed at our institutes. The existing setup is the first version of the miniPET machine consisting of four detector modules. Each detector module consists of an 8 x 8 LSO scintillator crystal block, a position sensitive photomultiplier, a digitizer including a digital signal processing board and an Ethernet interface board. There is no hardware coincidence detection implemented in the system and coincidence is determined based on a time stamp attached to every event by a digital CFD algorithm. The algorithm is implemented in the digital signal processing board and generates a time stamp with a coincidence resolution of less than 2 us. The data acquisition system is based on Ethernet network and is highly scalable in size and performance.
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| 4. |
- Imrek, J., et al.
(author)
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Internals and evaluation of the miniPET-II detector module
- 2007
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In: 2007 IEEE Nuclear Science Symposium Conference Record. - 1424409233 - 9781424409235 ; , s. 2930-2932
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Conference paper (peer-reviewed)abstract
- We report on the architecture of the System-on-Module (SoM) developed by our group for miniPET-II, the second version of our small animal PET scanner. The paper describes the hardware and software implementation details of the SoM we realized inside the miniPET-II detector module, the embedded Linux operation system, and the the initial results of bandwidth test measurements on the assembled SoM. Detailed description is given on the interfacing of the updated miniPET IP Core to the SoM, on the efficient data transfer method that implements device-to-device DMA transfer, and on the usage of User Datagram Protocol (UDP/IP) for high speed data transfer.
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| 5. |
- Kis, S. A., et al.
(author)
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Comparison of Monte Carlo simulated and measured performance parameters of miniPET scanner
- 2007
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In: Nuclear Instruments and Methods in Physics Research Section A. - : Elsevier BV. - 0168-9002 .- 1872-9576. ; 571:02-jan, s. 449-452
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Journal article (peer-reviewed)abstract
- In vivo imaging of small laboratory animals is a valuable tool in the development of new drugs. For this purpose, miniPET, an easy to scale modular small animal PET camera has been developed at our institutes. The system has four modules, which makes it possible to rotate the whole detector system around the axis of the field of view. Data collection and image reconstruction are performed using a data acquisition (DAQ) module with Ethernet communication facility and a computer cluster of commercial PCs. Performance tests were carried out to deter-mine system parameters, such as energy resolution, sensitivity and noise equivalent count rate. A modified GEANT4-based GATE Monte Carlo software package was used to simulate PET data analogous to those of the performance measurements. GATE was run on a Linux cluster of 10 processors (64 bit, Xeon with 3.0 GHz) and controlled by a SUN grid engine. The application of this special computer cluster reduced the time necessary for the simulations by an order of magnitude. The simulated energy spectra, maximum rate of true coincidences and sensitivity of the camera were in good agreement with the measured parameters.
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| 6. |
- Kis, S. A., et al.
(author)
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Performance Characteristics of a miniPET Scanner Dedicated to Small Animal Imaging
- 2005
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In: 2005 IEEE Nuclear Science Symposium Conference Record. - 0780392213 - 9780780392212 ; , s. 1645-1648
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Conference paper (peer-reviewed)abstract
- An easy to scale up modular PET scanner was developed for imaging small animals. Energy resolution, spatial resolution and count rate performance were determined as system parameters. The configuration provided an average energy resolution of 19.6 % and the image resolution ranges was 1.5 to 2.3 mm in radial direction. The sensitivity of the miniPET was 1.08 cps/kBq as determined using a point source. In addition, results of rat brain scan performed with FDG are given to characterize imaging capability of the system. The displayed data document that the miniPET scanner supports good quality brain imaging of small animals.
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| 7. |
- Valastyán, Iván, et al.
(author)
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LSO based dual slice helical CT and PET demonstrators
- 2011
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In: Nuclear Instruments and Methods in Physics Research Section A. - : Elsevier BV. - 0168-9002 .- 1872-9576. ; 633, s. S300-S302
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Journal article (peer-reviewed)abstract
- Two demonstrators, a spiralCT and a miniPET, have been designed and constructed for educational purposes. Computed tomographs (CTs) and positron emission tomographs (PETs) are some of the most commonly used structural and functional imaging devices in medicine, respectively. There is a need for transparent demonstrators where the principles of the different modalities and their functions are presented. The aim of the developments of these systems was to present the major building blocks of CT and PET for undergraduate students. Photon detection in both systems is based on small pixelised scintillation crystals with position sensitive PMT readout. Similar analogue and digital data processing based on FPGA technique is applied for the demonstrators and common image reconstruction and presentation software components are used.
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| 8. |
- Valastyán, Iván, et al.
(author)
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Novel time over threshold based readout method for MRI compatible small animal PET detector
- 2012
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In: 2012 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC). - : IEEE. - 9781467320306 ; , s. 1295-1299
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Conference paper (peer-reviewed)abstract
- Combined PET-MRI scanners start a new era in medical imaging. However the development of MRI compatible PET detector module is a challenging task. SiPM sensors are insensitive to magnetic field and constitute a promising solution. A drawback is the high dark current. A readout concept for SiPM based small animal PET detector module is presented in this paper. The results show that the readout of the SiPM is possible using only four ADC channels and the position map is comparable to the ideal solution. The detector modules based on the method are feasible solution for MRI compatible PET scanners.
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| 9. |
- Haak-Frendscho, M, et al.
(author)
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Histidine decarboxylase expression in human melanoma.
- 2000
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In: Journal of Investigative Dermatology. - : Elsevier BV. - 0022-202X .- 1523-1747. ; 115:3, s. 345-52
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Journal article (peer-reviewed)abstract
- Histamine has been implicated as one of the mediators involved in regulation of proliferation in both normal and neoplastic tissues. Histidine decarboxylase, the only enzyme that catalyzes the formation of histamine from L-histidine, is an essential regulator of histamine levels. In this study, we investigated the gene and protein expression of histidine decarboxylase in melanoma. Reverse transcriptase polymerase chain reaction and in situ hybridization studies of WM-35, WM-983/B, HT-168, and M1 human melanoma cell lines both resulted in positive signals for histidine decarboxylase messenger RNA. A polyclonal chicken antibody was developed against human histidine decarboxylase and protein expression was confirmed by western blot analysis of the cell lysates, revealing a predominant immunoreactive band at approximately 54 kDa corresponding to monomeric histidine decarboxylase. Protein expression of histidine decarboxylase was also shown by flow cytometric analysis and strong punctate cytoplasmic staining of melanoma cell lines. Moreover, both primary and metastatic human melanoma tissues were brightly stained for histidine decarboxylase. When compared with the very weak or no reactions on cultivated human melanocytes both western blot and immunohistochemical studies showed much stronger histidine decarboxylase expression in melanoma cells. These findings suggest that expression of histidine decarboxylase is elevated in human melanoma.
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| 10. |
- Imrek, J., et al.
(author)
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Development of an improved detector module for miniPET-II
- 2007
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In: 2006 IEEE Nuclear Science Symposium Conference Record. - : IEEE. - 1424405610 - 9781424405619 ; , s. 3037-3040
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Conference paper (peer-reviewed)abstract
- We present a new detector module developed for miniPET-II, the second generation of the miniPET small animal PET scanners. The improved module features new hardware components for better performance: LySO crystal material, increased number of crystal segments, Hamamatsu H9500 PSPMT, Xilinx Virtex-4 FPGA and Gigabit Ethernet. However, the principle of operation is the same: no hardware coincidence detection is implemented, data is acquired in list mode and transfered over an Ethernet network. The resulting new module is more suitable for full ring configurations.
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