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Träfflista för sökning "WFRF:(Heikkila W.J.) "

Search: WFRF:(Heikkila W.J.)

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  • Fall, Tove, et al. (author)
  • The Role of Adiposity in Cardiometabolic Traits : A Mendelian Randomization Analysis
  • 2013
  • In: PLoS Medicine. - : Public Library of Science (PLoS). - 1549-1277 .- 1549-1676. ; 10:6, s. e1001474-
  • Journal article (peer-reviewed)abstract
    • Background: The association between adiposity and cardiometabolic traits is well known from epidemiological studies. Whilst the causal relationship is clear for some of these traits, for others it is not. We aimed to determine whether adiposity is causally related to various cardiometabolic traits using the Mendelian randomization approach. Methods and Findings: We used the adiposity-associated variant rs9939609 at the FTO locus as an instrumental variable (IV) for body mass index (BMI) in a Mendelian randomization design. Thirty-six population-based studies of individuals of European descent contributed to the analyses. Age-and sex-adjusted regression models were fitted to test for association between (i) rs9939609 and BMI (n = 198,502), (ii) rs9939609 and 24 traits, and (iii) BMI and 24 traits. The causal effect of BMI on the outcome measures was quantified by IV estimators. The estimators were compared to the BMI-trait associations derived from the same individuals. In the IV analysis, we demonstrated novel evidence for a causal relationship between adiposity and incident heart failure (hazard ratio, 1.19 per BMI-unit increase; 95% CI, 1.03-1.39) and replicated earlier reports of a causal association with type 2 diabetes, metabolic syndrome, dyslipidemia, and hypertension (odds ratio for IV estimator, 1.1-1.4; all p<0.05). For quantitative traits, our results provide novel evidence for a causal effect of adiposity on the liver enzymes alanine aminotransferase and gamma-glutamyl transferase and confirm previous reports of a causal effect of adiposity on systolic and diastolic blood pressure, fasting insulin, 2-h post-load glucose from the oral glucose tolerance test, C-reactive protein, triglycerides, and high-density lipoprotein cholesterol levels (all p<0.05). The estimated causal effects were in agreement with traditional observational measures in all instances except for type 2 diabetes, where the causal estimate was larger than the observational estimate (p = 0.001). Conclusions: We provide novel evidence for a causal relationship between adiposity and heart failure as well as between adiposity and increased liver enzymes.
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  • Ungstrup, E., et al. (author)
  • Rocket-borne particle, field, and plasma observations in the cleft region
  • 1975
  • In: Geophysical Research Letters. - 0094-8276 .- 1944-8007. ; 2:7, s. 345-348
  • Journal article (peer-reviewed)abstract
    • First results of comprehensive observations of magnetic and electric fields, and ambient and suprathermal plasmas above the dayside auroral oval with rocket-borne instrumentation which penetrated the cleft region are reported. Measurements were also obtained equatorward and poleward of the cleft. Convection velocities as inferred from electric field measurements were generally toward noon equatorward of the cleft and were antisunward over the polar cap. Our observations of electron temperatures, electric fields and low-frequency electrostatic noise provide strong evidence of a plasma instability (Farley-Buneman) in the E-layer, which is associated with the appearance of the ‘slant E condition’ identified in ground-acquired ionograms. The positions of these measurements relative to that of the cleft were firmly established via the determination of the plasma environment with an electrostatic analyzer.
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  • Result 1-5 of 5
Type of publication
journal article (3)
reports (2)
Type of content
peer-reviewed (3)
other academic/artistic (2)
Author/Editor
Fälthammar, Carl-Gun ... (2)
Lyssenko, Valeriya (1)
Tuomi, Tiinamaija (1)
Groop, Leif (1)
Salomaa, Veikko (1)
Jula, Antti (1)
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Mannisto, Satu (1)
Perola, Markus (1)
Lind, Lars (1)
Syvänen, Ann-Christi ... (1)
Fall, Tove (1)
Isomaa, Bo (1)
van Zuydam, Natalie ... (1)
McCarthy, Mark I (1)
Ladenvall, Claes (1)
Tregouet, David Alex ... (1)
Orho-Melander, Marju (1)
Ikram, M. Arfan (1)
Amin, Najaf (1)
van Duijn, Cornelia ... (1)
Pedersen, Nancy L (1)
Ingelsson, Erik (1)
Virtamo, Jarmo (1)
Havulinna, Aki S. (1)
Ripatti, Samuli (1)
Kettunen, Johannes (1)
Thorleifsson, Gudmar (1)
Thorsteinsdottir, Un ... (1)
Stefansson, Kari (1)
Nelson, Christopher ... (1)
Hägg, Sara (1)
Mangino, Massimo (1)
Willemsen, Gonneke (1)
Madden, Pamela A. F. (1)
Gieger, Christian (1)
Peters, Annette (1)
Wichmann, H. Erich (1)
de Geus, Eco J. C. (1)
Martin, Nicholas G. (1)
Boomsma, Dorret I. (1)
Spector, Tim D. (1)
Kaprio, Jaakko (1)
Samani, Nilesh J. (1)
Jarvelin, Marjo-Riit ... (1)
Pedersen, A. (1)
Knekt, Paul (1)
Sonestedt, Emily (1)
Ploner, Alexander (1)
Metspalu, Andres (1)
Kee, Frank (1)
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University
Royal Institute of Technology (4)
Uppsala University (1)
Lund University (1)
Karolinska Institutet (1)
Language
English (5)
Research subject (UKÄ/SCB)
Natural sciences (4)
Medical and Health Sciences (1)

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