| 1. |
- Akita, Munehira, et al.
(författare)
-
Asian ergonomics in the new millennium
- 2000
-
Ingår i: Ergonomics for the New Millenium. - : Human Factors and Ergonomics Society. - 0945289138 ; , s. 690-691
-
Konferensbidrag (refereegranskat)abstract
- Asia has more than a half of the world population. However, ergonomics has not been widely applied with exceptions of Japan and Korea. Recently, the excitement of ergonomics is being spread to other countries such as Hong Kong, Taiwan, and Indonesia. Although there have been two regional conferences, PPCOE and SEA Conference, Asian ergonomists have not met together to discuss their activities in a world conference. Therefore, the objectives of this symposium is to provide the opportunities for them to discuss the current status of ergonomics and possibly joints efforts to promote ergonomics in Asia. At the same time, this symposium intends to introduce the ergonomics activities in Asia to Western and non-Asian ergonomists and to look for new guidance to enhance its activities from the world renowned exports who have experienced in working in Asia with Asian ergonomists. This syposium consists of two sessions: one panel session and one technical session
|
|
| 2. |
- Alfredson, Jens, 1970-
(författare)
-
Differences in Situational Awareness and How to Manage Them in Development of Complex Systems
- 2007
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Situationsmedvetenhet (Eng. Situational Awareness), (SA), handlar om att ha koll på läget och vara medveten om vad som händer. Redan då ett komplext system utvecklas får vi en möjlighet att påverka vilken SA en framtida användare av systemet kan komma att få. Det gäller att ta tillvara på detta tillfälle! Ibland uppträder skillnader i SA, beroende på en rad olika orsaker. Denna avhandling handlar om SA och hur man kan använda de skillnaderna vid utveckling av komplexa system. Detta är relevant vid utveckling av en rad olika typer av komplexa system, även om de flesta exempel i denna avhandling kommer från flygdomänen.Avhandlingen innehåller beskrivningar hämtade från litteratur inom området och förslag på utveckling av SA-teori utifrån fokus på just skillnader. Skillnaden mellan vad du behöver vara medveten om och vad du verkligen är medveten om föreslås ge en indikation om individens SA. Vidare föreslås skillnaden mellan vad du är medveten om och vad du tror dig vara medveten om också ge en indikation om individens SA. SA kan skattas för en grupp av människor som arbetar tillsammans, genom variationerna i hur samstämmiga deras uppfattningar är.Termen situationshantering (Eng. Situation Management), (SM), föreslås med en vidare mening än SA, inkluderande SA, men också varje del av perceptionscykeln, hantering av mentala resurser och hantering av situationen genom extern påverkan. SM är en väl lämpad term vid utveckling av komplexa system då fokus här är på situationen och hur den kan hanteras, snarare än fokus på vad en individ eller en grupp uppfattar.Att skatta skillnader i SA och att kunna särskilja olika typer av skillnader är viktiga förutsättningar för att kunna hantera skillnader i SA vid utveckling av komplexa system på ett bra sätt. I avhandlingen gås flera sätt att skatta sådana skillnader igenom och speciellt tas för- och nackdelar med ögonrörelsemätning upp. Med referens till litteraturen och till de bilagda artiklarna beskrivs skillnader i SA beroende på a) designalternativ, b) roller i processen från utveckling till användning c) kontext och d) analysnivå. Skillnaderna i SA föreslås ses som både kvantitativa (dvs. hög eller låg SA) och kvalitativa (tex. olika aspekter av en situation).Ansatser såsom SM, realtidsvärdering, mätning och analys av SA på flera nivåer samtidigt samt simulatorbaserad design föreslås för att hantera skillnader i SA vid utveckling av komplexa system.
|
|
| 3. |
- Alm, Torbjörn, 1941-
(författare)
-
Simulator-Based Design : Methodology and vehicle display application
- 2007
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Human-in-the-loop simulators have long been used in the research community as well as in industry. The aviation field has been the pioneers in the use of simulators for design purposes. In contrast, corresponding activities in the automotive area have been less widespread. Published reports on experimental activities based on human-in-the-loop simulations have focused on methods used in the study, but nobody seems to have taken a step back and looked at the wider methodological picture of Simulator-Based Design. The purpose of this thesis is to fill this gap by drawing, in part, upon the author’s long experience in this field.In aircraft and lately also in ground vehicles there has been a technology shift from pure mechanics to computer-based systems. The physical interface has turned into screen-based solutions. This trend towards glass has just begun for ground vehicles. This development in vehicle technology has opened the door for new design approaches, not only for design itself, but also for the development process. Simulator-Based Design (SBD) is very compatible with this trend. The first part of this thesis proposes a structure for the process of SBD and links it to the corresponding methodology for software design.In the second part of the thesis the focus changes from methodology to application and specifically to the design of three-dimensional situation displays. Such displays are supposed to support the human operator with a view of a situation beyond the more or less limited visual range. In the aircraft application interest focuses on the surrounding air traffic in the light of the evolving free-flight concept, where responsibility for separation between aircraft will be (partly) transferred from ground-based flight controllers to air crews. This new responsibility must be supported by new technology and the situational view must be displayed from the perspective of the aircraft. Some basic design questions for such 3D displays were investigated resulting in an adaptive interface approach, where the current situation and task govern the details of information presentation.The thesis also discusses work on situation displays for ground vehicles. The most prominent example may be the Night Vision system, where the road situation ahead is depicted on a screen in the cab. The existing systems are based on continuous presentation, an approach that we have questioned, since there is strong evidence for negative behavioral adaptation. This means, for example, that the driver will drive faster, since vision has been enhanced, and thereby consume the safety margins that the system was supposed to deliver. Our investigation supports a situation-dependant approach and no continuous presentation.In conclusion, the results from our simulator-based studies showed advantages for adaptive interface solutions. Such design concepts are much more complicated than traditional static interfaces. This finding emphasizes the need for more dynamic design resources in order to have a complete understanding of the situation-related interface changes. The use of human-in-the-loop simulators and deployment of Simulator-Based Design will satisfy this need.
|
|
| 4. |
- Anandapadmanaban, Madhanagopal, et al.
(författare)
-
High-resolution structure of TBP with TAF1 reveals anchoring patterns in transcriptional regulation
- 2013
-
Ingår i: Nature Structural & Molecular Biology. - : NATURE PUBLISHING GROUP, 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA. - 1545-9993 .- 1545-9985. ; 20:8, s. 1008-
-
Tidskriftsartikel (refereegranskat)abstract
- The general transcription factor TFIID provides a regulatory platform for transcription initiation. Here we present the crystal structure (1.97 angstrom) and NMR analysis of yeast TAF1 N-terminal domains TAND1 and TAND2 bound to yeast TBP, together with mutational data. We find that yeast TAF1-TAND1, which in itself acts as a transcriptional activator, binds TBPs concave DNA-binding surface by presenting similar anchor residues to TBP as does Mot1 but from a distinct structural scaffold. Furthermore, we show how TAF1-TAND2 uses an aromatic and acidic anchoring pattern to bind a conserved TBP surface groove traversing the basic helix region, and we find highly similar TBP-binding motifs also presented by the structurally distinct TFIIA, Mot1 and Brf1 proteins. Our identification of these anchoring patterns, which can be easily disrupted or enhanced, provides insight into the competitive multiprotein TBP interplay critical to transcriptional regulation.
|
|
| 5. |
- Andrésen, Cecilia, et al.
(författare)
-
Molecular characterization of the interaction between the disordered c-Myc transactivation domain and the TATA-binding protein (TBP)
-
Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- The proto-oncogene c-myc affects the occurrence, expansion, and evolution of numerous aggressive human cancers, and is often associated with the late-stage and/or poor prognostic disease. Regulation of target gene activity by c-Myc occurs through protein interactions with the c-Myc transactivation domain (TAD) which, in addition to binding the TATA-binding protein (TBP) also recruits a wide variety of co-activators and suppressor proteins. Here, we present a molecular model, based on NMR, X-ray crystallography and SPR measurements, which describes how the c-Myc TAD binds to TBP. Our model contributes to the understanding of how c-Myc can regulate individual genes as well as entire gene programs.
|
|
| 6. |
- Blumenstein, Kathrin, et al.
(författare)
-
Nutritional niche overlap potentiates the use of endophytes in biocontrol of a tree disease
- 2015
-
Ingår i: BioControl (Dordrecht). - : Springer Science and Business Media LLC. - 1386-6141 .- 1573-8248. ; 60:5, s. 655-667
-
Tidskriftsartikel (refereegranskat)abstract
- Asymptomatic endophytic fungi are often regarded as potent biocontrol agents in plants, but the competitive interactions between endophytes and other microbes within the same host plant are poorly understood. We tested a hypothesis that as compared to asymptomatic endophytes, an aggressive pathogen inhabiting the same host is able to utilize carbon substrates more efficiently. Using phenotype microarray, we determined the carbon utilization profiles of the highly virulent Dutch elm disease (DED) pathogen Ophiostoma novo-ulmi, and four asymptomatic elm (Ulmus spp.) endophyte isolates that were selected based on their differential association to the DED-susceptibility pattern of the host elms. The competitive interactions between isolates were evaluated using a niche overlap index. In contrast to our hypothesis, the studied endophytes exhibited extensive niche overlap with the pathogen, suggesting that some endophyte strains might protect elms against DED-pathogen through competition for substrates and provide new tools for biocontrol of DED.
|
|
| 7. |
- Chou, Chia-Ying, et al.
(författare)
-
Precipitation kinetics during post-heat treatment of a L-PBF processed SS446 ferritic stainless steel
-
Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- The microstructure response to post-heat treatments of SS446 ferritic stainless steel processed by laser powder bed fusion is investigated, with focus on the precipitation kinetics of Cr2N. Precipitation simulations are conducted using the precipitation module (TC-PRISMA) within the Thermo-Calc Software Package. The annealed microstructure is characterized by scanning electron microscopy and the results are used for model validation and calibration. The microstructure and hardness responses to post heat treatments is discussed in terms of optimal solid-solution strengthening in SS446 ferritic stainless steel alloys processed by laser-powder bed fusion.
|
|
| 8. |
|
|
| 9. |
- Chou, Chia-Ying, et al.
(författare)
-
Precipitation Kinetics During Post-heat Treatment of an Additively Manufactured Ferritic Stainless Steel
- 2022
-
Ingår i: Metallurgical and Materials Transactions. A. - : Springer Nature. - 1073-5623 .- 1543-1940. ; 53:8, s. 3073-3082
-
Tidskriftsartikel (refereegranskat)abstract
- The microstructure response of laser-powder bed fusion (L-PBF)-processed ferritic stainless steel (AISI 441) during post-heat treatments is studied in detail. Focus is on the precipitation kinetics of the Nb-rich phases: Laves (Fe2Nb) and the cubic carbo-nitride (NbC), as well as the grain structure evolution. The evolution of the precipitates is characterized using scanning and transmission electron microscopy (SEM and TEM) and the experimental results are used to calibrate precipitation kinetics simulations using the precipitation module (TC-PRISMA) within the Thermo-Calc Software package. The calculations reproduce the main trend for both the mean radii for the Laves phase and the NbC, and the amount of Laves phase, as a function of temperature. The calibrated model can be used to optimize the post-heat treatment of additively manufactured ferritic stainless steel components and offer a creator tool for process and structure linkages in an integrated computational materials engineering (ICME) framework for alloy and process development of additively manufactured ferritic steels.
|
|
| 10. |
|
|
