| 1. |
- Ewerman, Lea, et al.
(författare)
-
Immunomodulating Effects Depend on Prolactin Levels in Patients with Hyperprolactinemia
- 2020
-
Ingår i: Hormone and Metabolic Research. - Stuttgart : Thieme Medical Publishers. - 0018-5043 .- 1439-4286. ; 52:04, s. 228-235
-
Tidskriftsartikel (refereegranskat)abstract
- Prolactin is known to have immune modulatory effects acting through the prolactin receptor, which is present on a variety of immune cells. Certain chemokines contribute to form the type of T helper (Th) preponderance in the immune response. The objective of this work was to assess if hyperprolactinemia not related to pregnancy is associated with changes in circulating levels of chemokines and other immunological markers. In this cross sectional study, 35 patients with hyperprolactinemia (5 men), and 102 healthy blood donors (19 men) were included. Serum levels of Th1- Th2- and Th17-associated chemokines, C-reactive protein, immunoglobulins, and the B cell attracting chemokine CXCL13 were assessed. The hyperprolactinemic group had significantly higher levels of Th2 associated CCL22 (p=0.022), Th17 associated CXCL1 (p=0.001), B cell attracting CXCL13 (p=0.003), and C-reactive protein (p<0.001) compared to controls, and these proteins were also positively correlated with prolactin levels. While differences in CCL22, CXCL1, CXCL13, and C-reactive protein were present in patients with low or moderate hyperprolactinemia, no differences were observed at high (>3600 mU/l) prolactin levels. To evaluate a possible dose-associated response to prolactin, an in vitro model was used, showing prolactin-induced increase in T-helper cell activation at moderate levels, while activation decreased at higher levels. Hyperprolactinemia seems to have several immunomodulatory effects and was associated with increased levels of chemokines associated with Th2 and Th17 responses and B cell attraction. However, patients with greatly increased prolactin had normal levels of chemokines, and in vitro, high levels of prolactin decreased T-helper cell activation.
|
|
| 2. |
-
International Symposium on Terahertz Science and Technology between Japan and Sweden
- 2009
-
Samlingsverk (redaktörskap) (refereegranskat)abstract
- The organisers and hosts warmly welcome you to the second International Symposium on Terahertz Science and Technology between Japan and Sweden, at Chalmers University of Technology, Göteborg, on November 18-20, 2009. The symposium is organised by the Department of Microtechnology and Nanoscience (MC2) at Chalmers. The aim is to create a forum and platform where researchers from the two countries can discuss latest results and trends in the field of terahertz science and technology. This year we have two keynote and 19 invited lectures divided into nine sessions.Sandwiched between the optical on the short wavelength side and radio on the long wavelength extreme, the terahertz (THz) or far-infrared has long been considered the last remaining scientific gap in the electromagnetic spectrum. The broad spectrum of THz applications has attracted researchers from different disciplines dealing with optics and photonics, microwave engineering and semiconductor physics. The role of this meeting is not only bridging the THz-gap but also strengthening the collaboration between Japan and Sweden.Chalmers is a university of technology in which research and teaching are conducted on a broad front within technology, natural science and architecture. Chalmers was founded in 1829. The university is named after the major benefactor, William Chalmers, one of the directors of the successful Swedish East India Company in Göteborg. Chalmers became an independent foundation in 1994. The meeting will be held at William Chalmers private residence, Chalmerska huset, which was erected in 1805-1807 and designed in a neoclassical style.The workshop is sponsored by the Swedish Research Council (VR) and MC2, Chalmers. We would like to thank these organisations for their support. We would also like to thank everyone who helped to arrange Japan-Sweden Terahertz Symposium (JSTS) 2009: the international steering committee for advice; the local organising committee: Eva Hellberg, Aleksandra Malko, Aik-Yean Tang, Dr. Sergey Cherednichenko, Dr. Biddut Banik and Prof. Dag Winkler for all practical efforts; Eriko Naito and Prof. Anders Karlsson at the Embassy of Sweden in Tokyo; our host Anna Bergius Hartman during the stay in Chalmerska huset; Dr. Göran Alestig for arranging the lab tour; invited speakers and everyone who attends or contributes to this event.On behalf of the local organising committee, we would like to welcome you all and wish you a pleasant and fruitful stay in Göteborg.Welcome!Jan Stake JSTS 2009 Chairman
|
|
| 3. |
-
Proceedings of the 2nd International Symposium on Terahertz Science and Technology between Japan and Sweden
- 2010
-
Samlingsverk (redaktörskap) (refereegranskat)abstract
- Preface - Japan-Sweden Terahertz Symposium (JSTS) 2009.“BRIDGING THE GAP BETWEEN RADIO WAVES AND LIGHT”.The second International Symposium on Terahertz Science and Technology between Japan and Sweden, was held in Göteborg, Sweden, November 18-20, 2009. Chalmers vice president Stefan Bengtsson followed by two keynote lectures, presented by Professor Nishizawa and Professor Kollberg, opened the symposium. Successive invited lectures were held in Chalmerska huset, where scientists from both Japan and Sweden presented frontier research covering a wide range of aspects in the field of terahertz science, techniques and applications. The aim of this forum is to provide a platform where researchers from the two countries can discuss latest results and trends in the field of terahertz science and technology.Sandwiched between the optical on the short wavelength side and radio on the long wavelength extreme, the terahertz (THz) or far-infrared has long been considered the last remaining scientific gap in the electromagnetic spectrum. The broad spectrum of THz applications has attracted researchers from different disciplines dealing with optics and photonics, microwave engineering and semiconductor physics. The role of this meeting is not only bridging the THz-gap and expanding the use of the electromagnetic spectrum but also strengthening the collaboration between Japan and Sweden.
|
|
