SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Helleday T) "

Sökning: WFRF:(Helleday T)

  • Resultat 1-10 av 190
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • Berglund, U. W., et al. (författare)
  • Validation and development of MTH1 inhibitors for treatment of cancer
  • 2016
  • Ingår i: Annals of Oncology. - : Elsevier BV. - 0923-7534 .- 1569-8041. ; 27:12, s. 2275-2283
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Previously, we showed cancer cells rely on the MTH1 protein to prevent incorporation of otherwise deadly oxidised nucleotides into DNA and we developed MTH1 inhibitors which selectively kill cancer cells. Recently, several new and potent inhibitors of MTH1 were demonstrated to be non-toxic to cancer cells, challenging the utility of MTH1 inhibition as a target for cancer treatment. Material and methods: Human cancer cell lines were exposed in vitro to MTH1 inhibitors or depleted of MTH1 by siRNA or shRNA. 8-oxodG was measured by immunostaining and modified comet assay. Thermal Proteome profiling, proteomics, cellular thermal shift assays, kinase and CEREP panel were used for target engagement, mode of action and selectivity investigations of MTH1 inhibitors. Effect of MTH1 inhibition on tumour growth was explored in BRAF V600E-mutated malignant melanoma patient derived xenograft and human colon cancer SW480 and HCT116 xenograft models. Results: Here, we demonstrate that recently described MTH1 inhibitors, which fail to kill cancer cells, also fail to introduce the toxic oxidized nucleotides into DNA. We also describe a new MTH1 inhibitor TH1579, (Karonudib), an analogue of TH588, which is a potent, selective MTH1 inhibitor with good oral availability and demonstrates excellent pharmacokinetic and anti-cancer properties in vivo. Conclusion: We demonstrate that in order to kill cancer cells MTH1 inhibitors must also introduce oxidized nucleotides into DNA. Furthermore, we describe TH1579 as a best-in-class MTH1 inhibitor, which we expect to be useful in order to further validate the MTH1 inhibitor concept.
  •  
2.
  •  
3.
  •  
4.
  •  
5.
  •  
6.
  • Erickson, A, et al. (författare)
  • Spatially resolved clonal copy number alterations in benign and malignant tissue
  • 2022
  • Ingår i: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 608:7922, s. 360-
  • Tidskriftsartikel (refereegranskat)abstract
    • Defining the transition from benign to malignant tissue is fundamental to improving early diagnosis of cancer1. Here we use a systematic approach to study spatial genome integrity in situ and describe previously unidentified clonal relationships. We used spatially resolved transcriptomics2 to infer spatial copy number variations in >120,000 regions across multiple organs, in benign and malignant tissues. We demonstrate that genome-wide copy number variation reveals distinct clonal patterns within tumours and in nearby benign tissue using an organ-wide approach focused on the prostate. Our results suggest a model for how genomic instability arises in histologically benign tissue that may represent early events in cancer evolution. We highlight the power of capturing the molecular and spatial continuums in a tissue context and challenge the rationale for treatment paradigms, including focal therapy.
  •  
7.
  •  
8.
  •  
9.
  •  
10.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-10 av 190
Typ av publikation
tidskriftsartikel (154)
konferensbidrag (34)
annan publikation (1)
forskningsöversikt (1)
Typ av innehåll
refereegranskat (136)
övrigt vetenskapligt/konstnärligt (52)
populärvet., debatt m.m. (2)
Författare/redaktör
Helleday, T (177)
Berglund, UW (35)
Sanjiv, K (32)
Mortusewicz, O (22)
Scobie, M (22)
Koolmeister, T (21)
visa fler...
Loseva, O (19)
Gad, H (18)
Schultz, N (14)
Jemth, AS (14)
Wiita, E (11)
Calderon-Montano, JM (11)
Visnes, T (10)
Kalderen, C. (10)
Almlof, I. (10)
Rudd, SG (10)
Jenssen, D (9)
Llona-Minguez, S (9)
Benitez-Buelga, C (9)
Wallner, O (9)
Herr, P (8)
Desroses, M (8)
Lundback, T (8)
Hoglund, A. (7)
Hagenkort, A (7)
Homan, E (6)
Michel, M (6)
Henriksson, M (6)
Helleday, Ragnberth (6)
Arnaudeau, C (6)
Pham, T (6)
Brautigam, L (6)
Gokturk, C (6)
Rasti, A. (6)
Burgos-Moron, E (6)
Orta, ML (6)
Pudelko, L (6)
Das, I. (5)
Herold, N (5)
Hansson, J. (5)
Grander, D (5)
Hamdy, FC (5)
Altun, M (5)
Tarish, F (5)
Axelsson, H. (5)
Tuominen, R (5)
Hanna, BMF (5)
Schaller, T (5)
Lopez-Lazaro, M (5)
Groth, P (5)
visa färre...
Lärosäte
Karolinska Institutet (165)
Stockholms universitet (20)
Umeå universitet (7)
Kungliga Tekniska Högskolan (5)
Uppsala universitet (5)
Göteborgs universitet (3)
visa fler...
Lunds universitet (3)
RISE (2)
Linköpings universitet (1)
visa färre...
Språk
Engelska (189)
Odefinierat språk (1)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (26)
Naturvetenskap (7)
Teknik (2)
Samhällsvetenskap (1)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy