| 1. |
- Andersson, Björn, 1977, et al.
(författare)
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Protein profiling identified dissociations between growth hormone-mediated longitudinal growth and bone mineralization in short prepubertal children
- 2011
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Ingår i: Journal of Proteomics. - : Elsevier BV. - 1876-7737 .- 1874-3919. ; 74:1, s. 89-100
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Tidskriftsartikel (refereegranskat)abstract
- Growth hormone (GH) promotes longitudinal growth and bone mineralization. In this study, a proteomic approach was used to analyze the association between serum protein expression pattern and height-adjusted bone mineralization in short prepubertal children receiving GH treatment. Patterns of protein expression were compared with those associated with longitudinal bone growth. Specific protein expression patterns associated with changes in height-adjusted bone mineralization in response to GH treatment were identified. Out of the 37 peaks found in significant regression models, 27 were uniquely present in models correlated with changes in bone mineralization and 7 peaks were uniquely present in models correlated with changes in height. The peaks identified corresponded to apolipoproteins, transthyretin, serum amyloid A4 and hemoglobin beta. We conclude that a proteomic approach could be used to identify specific protein expression patterns associated with bone mineralization in response to GH treatment and that height-adjusted bone mineralization and longitudinal bone growth are regulated partly by the same and partly by different mechanisms. Protein isoforms with different post-translational modifications might be of importance in the regulation of these processes. However, further validation is needed to assess the clinical significance of the results.
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| 2. |
- Andersson, Björn, 1977, et al.
(författare)
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Proteins related to lipoprotein profile were identified using a pharmaco-proteomic approach as markers for growth response to growth hormone (GH) treatment in short prepubertal children
- 2009
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Ingår i: Proteome Science. - : Springer Science and Business Media LLC. - 1477-5956. ; 7
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: The broad range in growth observed in response to growth hormone (GH) treatment is mainly caused by individual variations in both GH secretion and GH sensitivity. Individual GH responsiveness can be estimated using evidence-based models that predict the response to GH treatment; however, these models can be improved. High-throughput proteomics techniques can be used to identify proteins that may potentially be used as variables in such models in order to improve their predictive ability. Previously we have reported that proteomic analyses can identify biomarkers that discriminate between short prepubertal children with idiopathic short stature (ISS) who show good or poor growth in response to GH treatment. In this study we used a pharmaco-proteomic approach to identify novel factors that correlate with the growth response to GH treatment in prepubertal children who are short due to GH deficiency or ISS. The study included 128 short prepubertal children receiving GH treatment, of whom 39 were GH-deficient and 89 had ISS. Serum protein expression profiles at study start and after 1 year of GH treatment were analyzed using SELDI-TOF. Cross-validated regression and random permutation analyses were performed to identify significant correlations between protein expression patterns and the 2-year growth response to GH treatment. RESULTS: At start of treatment we identified a combination of seven protein peaks that correlated with the 2-year growth response in the GH-deficient group (R2 = 0.73). After 1 year of treatment, a combination of four peaks in the GH-deficient group (R2 = 0.64), eight peaks in the ISS group R2 = 0.47) and eight peaks in the total study group correlated with the 2-year growth response R2 = 0.38).The peaks identified corresponded to apolipoproteins A-I, A-II, C-I, C-III, transthyretin and serum amyloid A 4, which are all part of the high-density lipoprotein. CONCLUSION: Using a proteomic approach we identified biomarkers related to the lipoprotein profile that could be used to predict growth response to GH treatment in prepubertal children who are short as a result of GH-deficiency or who have ISS.These results support our previous findings that apolipoproteins and transthyretin may have a role in GH sensitivity.
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| 3. |
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| 4. |
- Aronsson, Gunnar, et al.
(författare)
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Arbets- och organisationspsykologi : Individ och organisation i samspel
- 2012. - 1
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Bok (övrigt vetenskapligt/konstnärligt)abstract
- Boken anlägger ett brett perspektiv på individen i arbetslivet som spänner över både arbets- och organisationspsykologi. Författarna tar upp de ramar som modernt arbetsliv skapar och hur individen rör sig innanför dessa. De beskriver arbetets roll i livet, samspelet på arbetsplatsen och vilken betydelse det kan ha för individen. Likaså behandlas fenomen som organisationsförändringar, ledarskap och motivation. Författarna har en gedigen erfarenhet av undervisning och forskning inom ämnet vilket gör boken både pedagogiskt upplagd och uppdaterad inom de senaste rönen. Boken är skriven för studerande i psykologi och beteendevetenskapliga utbildningar samt i företagsekonomi med organisationsinriktning. Boken är även lämplig för HR-specialister, chefer och andra med intresse av hur samspelet mellan individ och organisation bidrar till att skapa hållbara arbetsvillkor och effektiva organisationer.
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| 5. |
- Bartonek, Asa, et al.
(författare)
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Head and Trunk Movements During Turning Gait in Children with Cerebral Palsy
- 2019
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Ingår i: Journal of motor behavior. - : ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD. - 0022-2895 .- 1940-1027. ; 51:4, s. 362-370
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Tidskriftsartikel (refereegranskat)abstract
- Thirty children with cerebral palsy (CP) and 22 typical developing (TD) were tested with 3D-gait analysis. At turning, trunk rotation was larger in CP2 (GMFCS II) than in TD and CP1 (GMFCS I), and head flexion was larger in CP3 (GMFCS III) than TD. Maximum head and trunk flexion values during the entire trial were larger in CP3 than in the other groups, and trunk flexion was larger in CP2 than in TD. Trial time increased with GMFCS-level. Less trunk rotation than TD and CP1 reflects spatial insecurity in CP2, which in CP3 is compensated by the walker. The flexed head and trunk in CP3 and trunk in CP2 may reflect deficits in proprioception and sensation requiring visual control of the lower limbs.
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| 6. |
- Bolk, Jenny, et al.
(författare)
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National population-based cohort study found that visual-motor integration was commonly affected in extremely preterm born children at six-and-a-half years
- 2018
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Ingår i: Acta Paediatrica. - : WILEY. - 0803-5253 .- 1651-2227. ; 107:5, s. 831-837
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Tidskriftsartikel (refereegranskat)abstract
- Aim: This study aimed to explain the relationship between visual-motor integration (VMI) abilities and extremely preterm (EPT) birth, by exploring the influence of perinatal variables, cognition, manual dexterity and ophthalmological outcomes. Methods: This was part of the population-based national Extremely Preterm Infant Study in Sweden (EXPRESS) study. We studied 355 children, born at a gestational age of <27 weeks from April 2004 to March 2007, and 364 term-born controls. At six-and-a-half years of age, we assessed VMI, cognitive function, motor skills and vision. VMI impairment was classified as <-1 standard deviation (SD). Results: The mean (SD) VMI score was 87 (+/- 12) in preterm children compared to 98 (+/- 11) in controls (p < 0.001). VMI impairment was present in 55% of preterm infants and in 78% of children born at 22-23 weeks. Male sex and postnatal steroids showed a weak association with poorer visual-motor performance, whereas low manual dexterity and cognitive function showed a stronger association. Conclusion: Poor VMI performance was common in this EXPRESS cohort of children born EPT. Its strong association to cognition and manual dexterity confirms that all of these factors need to be taken into account when evaluating risks in preterm born children.
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| 7. |
- Decker, Ralph, 1968, et al.
(författare)
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Protein markers of body composition in response to growth hormone (GH) treatment in short prepubertal children
- 2010
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Ingår i: Hormone Research Paediatr.
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Konferensbidrag (refereegranskat)abstract
- Background Recently our group identified lipoprotein biomarkers able to predict linear growth response to GH treatment in short prepubertal children. Previously, it was also shown that biomarkers identified by a proteomic approach were able to discriminate between good or poor growth responders to GH treatment. Hypothesis We hypothesize that high-throughput proteomics techniques can be used to identify proteins not only to predict longitudinal growth response, but also changes in body composition. Objectives The objectives are to implement newly identified biomarkers in future advanced prediction models to avoid over- and under-treatment with GH and to find surrogate markers for predictors difficult to access, e.g. growth hormone (GH) secretion capacity. Study design 128 short prepubertal children were included in the study receiving GH treatment, of whom 39 were GH-deficient and 89 had idiopathic short stature (ISS). Serum protein expression profiles at study start and after 1 year of GH treatment were analyzed using surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF-MS). Body composition after 2 years was analyzed by DEXA. Statistics Cross-validated regression and random permutation analyses were performed to identify significant correlations between protein expression patterns and the 2-year changes in body composition during GH treatment. Results In the present study we identified biomarkers able to predict lean mass (from arms and legs) and the decrease in subcutaneous fat mass (from arms and legs) at 2 yrs using a pharmaco-proteomic approach. Apolipoproteins were identified as unique markers of the GH treatment on lean mass and of fat mass (r2 >0.32, p<0.05). Serum amyloid A4, belonging to the apolipoprotein family, was a marker of both muscle and fat mass. Conclusion We show a proteomic approach being suitable to identify biomarkers before start of GH treatment playing a role in lipid transport and lipid metabolism able to predict body composition at 1 and 2 years of GH treatment.
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| 8. |
- Decker, Ralph, 1968, et al.
(författare)
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Protein markers predict body composition during growth hormone (GH) treatment in short prepubertal children.
- 2013
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Ingår i: Clinical Endocrinology. - : Wiley. - 0300-0664 .- 1365-2265. ; 79:5, s. 675-82
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: A high-throughput pharmaco-proteomic approach has previously been successfully used to identify lipoprotein biomarkers related to changes in longitudinal growth and bone mass in response to growth hormone (GH) treatment. The aim of this study was to identify protein markers involved in the diverse anabolic and lipolytic remodelling of body composition during GH treatment. DESIGN, PATIENTS AND MEASUREMENTS: The study population consisted of 128 prepubertal children receiving GH treatment. Thirty-nine were short as a result of GH deficiency and 89 had idiopathic short stature (ISS). Serum protein expression profiles at study start and after one year of GH treatment were analysed using surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS). Body composition was analysed by dual-energy X-ray absorptiometry (DXA), reliably estimating muscle mass from appendicular (arms and legs) lean soft tissue mass (LST). DXA was also used to estimate appendicular bone mineral content (BMC) and fat mass for the total body. RESULTS: Specific protein expression patterns associated with GH response in different body compartments were identified. Among identified proteins different isoforms of nutrition markers such as apolipoproteins (Apo) were recognized; Apo C-I, Apo A-II, serum amyloid A4 (SAA4) and transthyretin (TTR). In addition, unidentified peaks were associated with GH effects on specific body compartments. CONCLUSIONS: Our results suggest that unique protein markers are associated with remodelling of different body compartments during GH treatment, which in the future might be useful to optimize GH treatment not only with regard to longitudinal growth. © 2013 Blackwell Publishing Ltd.
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| 9. |
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Ett gränslöst arbetsliv : temanummer till Gunnar Aronsson
- 2013
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Samlingsverk (redaktörskap) (refereegranskat)abstract
- Genom detta temanummer i Arbetsmarknad & Arbetsliv vill vi uppmärksamma den forskning och det arbete för svenskt arbetsliv som professor Gunnar Aronsson har bedrivit under sin långa verksamhet som forskare. Under sina anställningar vid Psykologiska institutionen på Stockholms universitet och på Arbetslivsinstitutet har Gunnar kommit att bli en av de absoluta centralfigurerna inom svensk arbetslivsforskning. Han har på ett högst påtagligt sätt själv bedrivit, medverkat i och inspirerat till forskning som på många viktiga sätt bidragit till att utveckla förståelsen av arbetsvillkor, arbetsmiljöns betydelse för de anställdas hälsa och välbefinnande samt vad arbetslivets förändring betyder för personer på arbetsmarknaden.Som tema för detta numer har vi valt ”Ett gränslöst arbetsliv”. Gränslöst arbete är ett tema i forskningen som Gunnar bedrivit i samarbete med en lång rad prominenta kolleger och som bland annat resulterat i två böcker (Allvin m fl 2006, 2011). I det fallet har gränslöshet handlat om hur avregleringen av arbetet när det gäller tid, rum och innehåll gjort arbetet mer otydligt. Men gränslöshet kan också appliceras på en enskild persons – i detta fall Gunnar Aronssons – arbetsliv. Det är i högsta grad gränslöst i dessa aspekter. När det gäller Gunnars gränslösa arbetsliv kan vi, i termer av tid, konstatera att det i hans fall inte finns någon åldersgräns för hur länge man kan vara produktiv och bidra till arbetslivsforskningen. När det gäller den rumsliga dimensionen har Gunnar gjort gränsöverskridande insatser på både Stockholms universitet och Arbetslivsinstitutet men också genom samarbete med kolleger på andra platser. Innehållsligt sett har Gunnar Aronsson svept över en mängd olika teman men trots denna gränslöshet finns ändå en gemensam nämnare – att göra arbetslivet till en så bra plats som möjligt för den anställde.Med detta temanummer har vi haft som ambition att särskilt belysa några teman i Gunnar Aronssons forskning. Vi har bjudit in en mängd författarkonstellationer, med tidigare och nuvarande samarbeten och kopplingar till Gunnar, att efter sedvanligt granskningsförfarande medverka till temanumret. Många forskare har bidragit till artiklarna vilket illustrerar omfattningen av det sociala kontaktnät som omger Gunnar Aronsson. De som skrivit de olika artiklarna har alla på olika sätt samarbetat med Gunnar genom åren, som handledare för hans doktorsavhandling, som kolleger och som doktorander. I varje artikel finns en not som klargör forskarnas samarbete med Gunnar Aronsson.
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| 10. |
- Gäddlin, Per-Olof, 1946-, et al.
(författare)
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Hospital readmissions and morbidity in a fifteen-year follow-up of very low birthweight children in Southeast Sweden
- 2007
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Ingår i: Acta Paediatrica. - : Wiley. - 0803-5253 .- 1651-2227. ; 96:4, s. 499-505
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Tidskriftsartikel (refereegranskat)abstract
- Aim: To study the effect of very low birthweight on hospital care and morbidity, and their relationship to gender, birthweight and neonatal complications. Methods: Eighty-five very low birthweight (VLBW; <= 1500 g) children and term controls born in 1987-1988 in south-east region of Sweden were checked in registers regarding readmissions and diagnoses, need for habilitation and child psychiatric care up to 15 years of age. Ophthalmological examinations were made at age 4 in 64 of VLBW and 61 of control children, and at age 15 in 59 of VLBW and 55 of control children. Results: VLBW boys had three times more readmissions compared with normal weight control boys (p = 0.003). Neonatal risk factors for readmissions were gestational age under 30 weeks (OR 3.1), birthweight less than 1000 g (OR 4.6), mechanical ventilation (OR 9.5) and more than 60 days' stay in neonatal ward (OR 5.0). A minority of VLBW children had an impairment/handicap such as cerebral palsy (CP) in five (5.9%) children, attention deficit hyperactivity disorders (ADHD) in five children, and blindness due to retinopathy of prematurity in one child. One child in the control group had ADHD. At the 15-year examination median visual acuity in the best eye was better in the control group (1.6) than in the VLBW group (1.3) (p = 0.009). 32% of VLBW children and 11% of controls had latent or manifest strabismus (p = 0.007). Conclusion: Risk factors for readmissions were gender, low gestational age, birthweight < 1000 g or mechanical ventilation. A minority of VLBW children had a handicap that influenced their daily life activities at 15 years of age.
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