| 1. |
- Askling, Helena H, et al.
(författare)
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Serologic Analysis of Returned Travelers with Fever, Sweden
- 2009
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Ingår i: Emerging Infectious Diseases. - Atlanta, GA, USA : U.S. Department of Health and Human Services * Centers for Disease Control and Prevention. - 1080-6040 .- 1080-6059. ; 15:11, s. 1805-1808
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Tidskriftsartikel (refereegranskat)abstract
- We studied 1,432 febrile travelers from Sweden who had returned from malaria-endemic areas during March 2005-March 2008. In 383 patients, paired serum samples were blindly analyzed for influenza and 7 other agents. For 21% of 115 patients with fever of unknown origin, serologic analysis showed that influenza was the major cause.
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| 2. |
- Blessborn, Daniel, et al.
(författare)
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Determination of pyronaridine in whole blood by automated solid-phase extraction and high-performance liquid chromatography
- 2003
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Ingår i: Therapeutic Drug Monitoring. - : Ovid Technologies (Wolters Kluwer Health). - 0163-4356 .- 1536-3694. ; 25:3, s. 264-270
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Tidskriftsartikel (refereegranskat)abstract
- A new extraction procedure for the analysis of pyronaridine in whole blood is presented. A weak cation exchanger with a carboxylic acid (CBA) sorbent was found to be a suitable solid phase sorbent for the extraction of pyronaridine. High-performance liquid chromatography with UV detection at 278 nm and an electrochemical detector at +0.75 V is used. The electrochemical detector gives higher selectivity than the UV detector. The separation was performed using a C18 reversed phase column with mobile phase of acetonitrile-phosphate buffer (0.01 mol/L, pH 2.5)- sodium perchlorate (1.0 mol/L; 22:77:1, v/v/v). The within-day RSDs were below 5% at all concentration levels between 75 nmol/L and 1500 nmol/L, and the between-day RSDs were below 14% at all concentration levels. The limit of quantification was about 50 nmol/L in 1000 microL whole blood with an RSD of 20% or less on a day-to-day basis. The stability of pyronaridine is increased if the pH is less than 3 in water solutions. In whole blood, the concentration decreases by about 10% for each freeze-thaw cycle performed. At room temperature (about 22 degrees C), pyronaridine concentration in whole blood decreases by about 10% within 12 to 24 hours.
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| 3. |
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| 4. |
- Euler, Elias, et al.
(författare)
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Science students’ experience of spatial scales : a phenomenographic pilot study
- 2022
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Konferensbidrag (refereegranskat)abstract
- We report on the initial findings of a pilot study from a larger project investigating the teaching and learning of spatial/temporal scales in science. Pre-service science teachers from physics and biology were interviewed over Zoom while completing a ranking task for objects ranging from a proton to animal cells to the Universe. A phenomenographic analysis was carried out to determine the qualitatively different ways in which science students experience spatial scales.
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| 5. |
- Euler, Elias, et al.
(författare)
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The scale of it all : Students' experiences of spatial scales
- 2022
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Konferensbidrag (refereegranskat)abstract
- This talk reports on the preliminary data and initial findings of a pilot study from a larger project investigating the teaching and learning of spatial/temporal scales in science. We video-recorded pre-service science teachers from physics and biology while completing a ranking task for objects ranging in size from the scale of a proton to the scale of the Universe. From this data, a phenomenographic analysis was carried out to determine the qualitatively different ways in which science students experience spatial scales.
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| 6. |
- Hellgren, Johan, 1966-, et al.
(författare)
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Bias of feedback cancellation algorithms in hearing aids based on direct closed loop identification
- 2001
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Ingår i: IEEE transactions on speech and audio processing. - : Institute of Electrical and Electronics Engineers (IEEE). - 1063-6676 .- 1558-2353. ; 9:8, s. 906-913
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Tidskriftsartikel (refereegranskat)abstract
- The undesired effects of acoustic feedback of hearing aids can be reduced with an internal feedback path that is an estimate of the external feedback path. This paper analyzes the limiting estimate of the feedback for feedback cancellation schemes that apply some recursive prediction error method with a quadratic norm, e.g., least mean square (LMS) and recursive least squares (RLS), to the output and input signals of the hearing aid to identify the feedback path. The data used for identification is then collected in closed loop and the estimate used in one recursion will affect the data used in succeeding recursions. These properties have to be considered in the analysis. The analysis shows that the limiting estimate may be biased if there is an error in the used model of the input signal to the hearing aid, and that the system is not identifiable unless a second input signal to the system is added to the output of the hearing aid or the signal processing of the hearing aid used to modify the signal to the impaired ear is nonlinear. The limiting estimate is presented as the solution to an optimization problem in the frequency domain. An analytical expression of the limiting estimate is presented for a special case. For other cases an algorithm is presented that can be used to find a numerical solution. The results can be useful when the model structure used with the recursive identification is chosen.
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| 7. |
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| 8. |
- Holmström, Gerd, et al.
(författare)
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Optical coherence tomography is helpful in the diagnosis of foveal hypoplasia
- 2010
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Ingår i: Acta Ophthalmologica. - : Wiley. - 1755-375X .- 1755-3768. ; 88:4, s. 439-442
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: To investigate whether optical coherence tomography (OCT) is helpful in the diagnosis of foveal hypoplasia in children. Methods: Children with albinism and aniridia were examined with Stratus OCT 3 software 4.0.1 (Carl Zeiss Meditec, Dublin, California, USA). A qualitative examination of the macular area was performed with a 128 A-scans/second-single-scan. Macular thickness was measured quantitatively with an automatic fast macular map protocol. The average thickness/volume of the macula was presented as numerical values and as a false colour code in nine modified early treatment of diabetic retinopathy study (ETDRS) areas (A1-A9). A previously collected control group of children was used for comparison. Results: Macular thickness in 13 children with albinism and three children with aniridia was measured with OCT. Comparison with healthy children in the same population was performed. Patients with albinism and aniridia had significantly thicker central macula (A1) and foveola than children in the control group. Conclusion: OCT was found to be useful in the diagnosis of foveal hypoplasia in children.
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| 9. |
- Jallow, Amadou, et al.
(författare)
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Common problems with antiretroviral therapy among three Swedish Groups of HIV infected individuals
- 2007
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Ingår i: Pharmacy World & Science. - : Springer Science and Business Media LLC. - 0928-1231 .- 1573-739X. ; 29:4, s. 422-429
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: The main objective of this study was to identify and compare the common problems and difficulties associated with combination antiretroviral therapy (CART) as experienced by three major groups of HIV infected individuals (homo- or bisexuals, former injecting drug users and origins of Sub-Saharan Africa) in Sweden. METHODS: Based on the results from in-depth interviews with 15 representatives from the three major groups, a questionnaire was designed for use in a problem detection study (PDS). The study was conducted with 195 HIV-positive patients residing in the major cities of Sweden. RESULTS: The overall response rate was 79%. The problems identified in all three groups were negative attitudes from the public, worries about disease progression or therapy failure, medication or drug-related problems and problems in connection to pharmacy visits. A specific problem in the homo- or bisexual group was drug-related problems such as adverse effects, drug interactions and pill burden. For former injecting drug users, the specific problem was disease-related conflicts with relatives and the problem of coping with the social and psychological burden caused by the HIV infection. The African group termed the risk of exposing their medication at the pharmacy as a specific problem, as this could reveal their HIV status. CONCLUSIONS: Our findings regarding problems with CART in three patient groups in Sweden may be of use to tailor pharmacy care to HIV infected individuals. General strategies to improve adherence need to be complemented with approaches that will address the specific needs for the different patient groups affected by HIV. Further studies on group-specific interventions that promote concordance and adherence to CART will be necessary to minimize therapy failure and viral resistance.
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| 10. |
- Jallow, Amadou, et al.
(författare)
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Pharmacy care perspectives on problems with HIV antiretroviral therapy in Sweden
- 2007
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Ingår i: Pharmacy World & Science. - : Springer Science and Business Media LLC. - 0928-1231 .- 1573-739X. ; 29:4, s. 412-421
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: This study has three main objectives (1) to identify the major problems or difficulties pharmacy staff in Sweden experience regarding pharmacy care of patients receiving antiretroviral therapy, (2) to identify the perceptions of pharmacy staff regarding what are patient-related concerns with antiretroviral therapy and (3) to compare the extent to which pharmacy staff awareness matches patient perceptions regarding what are the major problems or difficulties associated with antiretroviral therapy. METHODS: A problem detection study (PDS) containing two questionnaires was conducted: one to be completed by pharmacy staff and another to be completed by both pharmacy staff and patients. In the latter survey, staff were asked about what they thought that patients would have responded. Staff and patient responses were then matched and compared with one another. RESULTS: The pharmacy staff expressed their need for continuous education so as to assist the patients with their complex regimens. The staff were aware that patients were worried about therapy failure and viral resistance, medication-related problems and negative attitudes from the public. The staff however were less aware of the extent to which patients worried about not having their HIV infection under control. The staff also valued written patient information to a much higher extent than the patients. CONCLUSIONS: The pharmacy staff' awareness of the major problems HIV patients are experiencing seems incomplete and may lead to lack of concordance between the patients and pharmacy staff. This in turn may lead to non-adherence and poor therapy outcomes. Pharmacy staff should be encouraged to improve and systematically assess patient issues regarding antiretroviral therapy. Through assessing patient needs and concerns, the pharmacists can better identify patient needs and thus better tailor their educational and behavioural interventions to improve therapy outcomes.
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