| 1. |
- Sánchez Van Kammen, Mayte, et al.
(författare)
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Characteristics and Outcomes of Patients with Cerebral Venous Sinus Thrombosis in SARS-CoV-2 Vaccine-Induced Immune Thrombotic Thrombocytopenia
- 2021
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Ingår i: JAMA Neurology. - : American Medical Association. - 2168-6149 .- 2168-6157. ; 78:11, s. 1314-1323
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Tidskriftsartikel (refereegranskat)abstract
- Importance: Thrombosis with thrombocytopenia syndrome (TTS) has been reported after vaccination with the SARS-CoV-2 vaccines ChAdOx1 nCov-19 (Oxford-AstraZeneca) and Ad26.COV2.S (Janssen/Johnson & Johnson).Objective: To describe the clinical characteristics and outcome of patients with cerebral venous sinus thrombosis (CVST) after SARS-CoV-2 vaccination with and without TTS.Design, Setting, and Participants: This cohort study used data from an international registry of consecutive patients with CVST within 28 days of SARS-CoV-2 vaccination included between March 29 and June 18, 2021, from 81 hospitals in 19 countries. For reference, data from patients with CVST between 2015 and 2018 were derived from an existing international registry. Clinical characteristics and mortality rate were described for adults with (1) CVST in the setting of SARS-CoV-2 vaccine-induced immune thrombotic thrombocytopenia, (2) CVST after SARS-CoV-2 vaccination not fulling criteria for TTS, and (3) CVST unrelated to SARS-CoV-2 vaccination.Exposures: Patients were classified as having TTS if they had new-onset thrombocytopenia without recent exposure to heparin, in accordance with the Brighton Collaboration interim criteria.Main Outcomes and Measures: Clinical characteristics and mortality rate.Results: Of 116 patients with postvaccination CVST, 78 (67.2%) had TTS, of whom 76 had been vaccinated with ChAdOx1 nCov-19; 38 (32.8%) had no indication of TTS. The control group included 207 patients with CVST before the COVID-19 pandemic. A total of 63 of 78 (81%), 30 of 38 (79%), and 145 of 207 (70.0%) patients, respectively, were female, and the mean (SD) age was 45 (14), 55 (20), and 42 (16) years, respectively. Concomitant thromboembolism occurred in 25 of 70 patients (36%) in the TTS group, 2 of 35 (6%) in the no TTS group, and 10 of 206 (4.9%) in the control group, and in-hospital mortality rates were 47% (36 of 76; 95% CI, 37-58), 5% (2 of 37; 95% CI, 1-18), and 3.9% (8 of 207; 95% CI, 2.0-7.4), respectively. The mortality rate was 61% (14 of 23) among patients in the TTS group diagnosed before the condition garnered attention in the scientific community and 42% (22 of 53) among patients diagnosed later.Conclusions and Relevance: In this cohort study of patients with CVST, a distinct clinical profile and high mortality rate was observed in patients meeting criteria for TTS after SARS-CoV-2 vaccination..
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| 2. |
- Scutelnic, Adrian, et al.
(författare)
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Management of Cerebral Venous Thrombosis Due to Adenoviral COVID-19 Vaccination.
- 2022
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Ingår i: Annals of neurology. - : Wiley. - 1531-8249 .- 0364-5134. ; 92:4, s. 562-573
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Tidskriftsartikel (refereegranskat)abstract
- Cerebral venous thrombosis (CVT) caused by vaccine-induced immune thrombotic thrombocytopenia (VITT) is a rare adverse effect of adenovirus-based severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) vaccines. In March 2021, after autoimmune pathogenesis of VITT was discovered, treatment recommendations were developed. These comprised immunomodulation, non-heparin anticoagulants, and avoidance of platelet transfusion. The aim of this study was to evaluate adherence to these recommendations and its association with mortality.We used data from an international prospective registry of patients with CVT after the adenovirus-based SARS-CoV-2 vaccination. We analyzed possible, probable, or definite VITT-CVT cases included until January 18, 2022. Immunomodulation entailed administration of intravenous immunoglobulins and/or plasmapheresis.Ninety-nine patients with VITT-CVT from 71 hospitals in 17 countries were analyzed. Five of 38 (13%), 11 of 24 (46%), and 28 of 37 (76%) of the patients diagnosed in March, April, and from May onward, respectively, were treated in-line with VITT recommendations (p<0.001). Overall, treatment according to recommendations had no statistically significant influence on mortality (14/44 [32%] vs 29/55 [52%], adjusted odds ratio [OR]=0.43, 95% confidence interval [CI]=0.16-1.19). However, patients who received immunomodulation had lower mortality (19/65 [29%] vs 24/34 [70%], adjusted OR=0.19, 95% CI=0.06-0.58). Treatment with non-heparin anticoagulants instead of heparins was not associated with lower mortality (17/51 [33%] vs 13/35 [37%], adjusted OR=0.70, 95% CI=0.24-2.04). Mortality was also not significantly influenced by platelet transfusion (17/27 [63%] vs 26/72 [36%], adjusted OR=2.19, 95% CI=0.74-6.54).In patients with VITT-CVT, adherence to VITT treatment recommendations improved over time. Immunomodulation seems crucial for reducing mortality of VITT-CVT. ANN NEUROL 2022;92:562-573.
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| 3. |
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| 4. |
- Austeng, Dordi, et al.
(författare)
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Incidence of and risk factors for neonatal morbidity after active perinatal care : extremely preterm infants study in Sweden (EXPRESS)
- 2010
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Ingår i: Acta Paediatrica. - : Wiley. - 0803-5253 .- 1651-2227. ; 99:7, s. 978-992
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Tidskriftsartikel (refereegranskat)abstract
- Aims: The aim of this study was to determine the incidence of neonatal morbidity in extremely preterm infants and to identify associated risk factors. Methods: Population based study of infants born before 27 gestational weeks and admitted for neonatal intensive care in Sweden during 2004-2007. Results: Of 638 admitted infants, 141 died. Among these, life support was withdrawn in 55 infants because of anticipation of poor long-term outcome. Of 497 surviving infants, 10% developed severe intraventricular haemorrhage (IVH), 5.7% cystic periventricular leucomalacia (cPVL), 41% septicaemia and 5.8% necrotizing enterocolitis (NEC); 61% had patent ductus arteriosus (PDA) and 34% developed retinopathy of prematurity (ROP) stage >= 3. Eighty-five per cent needed mechanical ventilation and 25% developed severe bronchopulmonary dysplasia (BPD). Forty-seven per cent survived to one year of age without any severe IVH, cPVL, severe ROP, severe BPD or NEC. Tocolysis increased and prolonged mechanical ventilation decreased the chances of survival without these morbidities. Maternal smoking and higher gestational duration were associated with lower risk of severe ROP, whereas PDA and poor growth increased this risk. Conclusion: Half of the infants surviving extremely preterm birth suffered from severe neonatal morbidities. Studies on how to reduce these morbidities and on the long-term health of survivors are warranted.
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| 5. |
- Barth, Ruud, et al.
(författare)
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Using ROS for agricultural robotics : design considerations and experiences
- 2014
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Ingår i: RHEA-2014. ; , s. 509-518
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Konferensbidrag (refereegranskat)abstract
- We report on experiences of using the ROS middleware for developmentof agricultural robots. We describe software related design considerations for all maincomponents in developed subsystems as well as drawbacks and advantages with thechosen approaches. This work was partly funded by the European Commission(CROPS GA no 246252).
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| 6. |
- Buervenich, Silvia, et al.
(författare)
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A rare truncating mutation in ADH1C (G78Stop) shows significant association with Parkinson disease in a large international sample.
- 2005
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Ingår i: Archives of neurology. - : American Medical Association (AMA). - 0003-9942. ; 62:1, s. 74-8
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Alcohol dehydrogenases (ADHs) may be involved in the pathogenesis of neurodegenerative disorders because of their multiple roles in detoxification pathways and retinoic acid synthesis. In a previous study, significant association of an ADH class IV allele with Parkinson disease (PD) was found in a Swedish sample. PATIENTS: The previously associated single-nucleotide polymorphism plus 12 further polymorphisms in the ADH cluster on human chromosome 4q23 were screened for association in an extension of the original sample that now included 123 Swedish PD patients and 127 geographically matched control subjects. A rare nonsense single-nucleotide polymorphism in ADH1C (G78stop, rs283413) was identified in 3 of these patients but in no controls. To obtain sufficient power to detect a possible association of this rare variant with disease, we screened a large international sample of 1076 PD patients of European ancestry and 940 matched controls. RESULTS: The previously identified association with an ADH class IV allele remained significant (P<.02) in the extended Swedish study. Furthermore, in the international collaboration, the G78stop mutation in ADH1C was found in 22 (2.0%) of the PD patients but only in 6 controls (0.6%). This association was statistically significant (chi(2)(1) = 7.5; 2-sided P = .007; odds ratio, 3.25 [95% confidence interval, 1.31-8.05]). In addition, the G78stop mutation was identified in 4 (10.0%) of 40 Caucasian index cases with PD with mainly hereditary forms of the disorder. CONCLUSION: Findings presented herein provide further evidence for mutations in genes encoding ADHs as genetic risk factors for PD.
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| 7. |
- Georgsson, Fredrik, et al.
(författare)
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Development of an Autonomous Path Tracking Forest Machine : a status report
- 2005
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- In many respects traditional automation in the forest-machine industry has reached an up- per limit, since the driver already has to deal with an excess of information and take too many decisions at a very high pace. To further automation still, introduction of semi-autonomous and autonomous functions are expected and considered necessary. This paper describes an ongoing project along these ideas. We describe the development of the hardware and software of an unmanned shuttle that shifts timber from the area of felling to the main roads for fur- ther transportation. A new path-tracking algorithm is introduced, and demonstrated as being superior to standard techniques, such as Follow-the-Carrot and Pure-Pursuit. To facilitate the research and development, a comprehensive software architecture for sensor and actuator interfacing is developed. Obstacle avoidance is accomplished by a new kind of radar, developed for and by the automotive industry. Localization is accomplished by a Kalman filter combining data from a Real-Time Kinematic Differential GPS/GLONASS and a gyro/compass. Tests conducted on a simulator and a small-scale robot show promising results. Tests on the real forest machine are ongoing, and will be completed before the end of 2005.
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| 8. |
- Hellström, Thomas, 1956-, et al.
(författare)
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A Java-based middleware for control and sensing in mobile robotics
- 2008
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Ingår i: International Conference on Intelligent Automation and Robotics 2008. - 9789889867102 ; , s. 649-654
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Konferensbidrag (refereegranskat)abstract
- Many of the existing mobile-robot software packages do not include handling of sensors and actuators in a sufficiently systematic and uniform way, as described later in this section. The software framework proposed in this paper, denoted NAV2000, addresses the specific need for interchangeability of components in robotics. At the lowest level, sensors, and sometimes also actuators, often have to be replaced by similar, yet not identical, components. At a higher level, the target vehicle often changes during the work process. The presented software provides a framework that supports these replacements and allows configurations of sensors, actuators, and target machines to be specified and manipulated in an efficient manner. The system can be distributed over a network of computers if some software modules require more computing power, i.e. more hardware can be added to the system without any software changes. To accomplish sufficient monitoring of the system's health, a dedicated system keeps track of all software modules. The system uses logfiles to enable convenient debugging and performance analysis of hardware and software modules. The software has been developed as part of, and is currently in use in, a R&D-project for an autonomous path-tracking forest machine.
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| 9. |
- Hellström, Thomas, et al.
(författare)
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A Software Framework for Control and Sensing in Mobile Robotics
- 2007
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Many of the existing mobile-robot softwares do not include handling of sensors and actuators in a sufficiently systematic and uniform way. The software framework proposed in this paper addresses the specific need for interchangeability of components in robotics. At the lowest level, sensors, and sometimes also actuators, often have to be replaced by similar, yet not identical, components. At a higher level, the target vehicle for the developed system often changes during the work process. The presented software provides a framework that supports these replacements and allows configurations of sensors, actuators, and target machines to be specified and manipulated in an efficient manner. The system can be run on several different computers if some software modules require more computing power. To accomplish sufficient monitoring of the system's health, a dedicated system keeps track of all software modules loaded onto the local computer, and also communicates with health monitors in all other computers running the system. The overall health of every module as well as a more detailed description of possible problems is presented graphically. In addition to this, the system uses logfiles to enable convenient debugging and performance analysis of hardware and software modules. The software has been developed as part of, and is currently in use in, a R&D-project for an autonomous path-tracking forest machine.
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| 10. |
- Hellström, Thomas, et al.
(författare)
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Autonomous forest machines : Past present and future
- 2008
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- The feasibility of using autonomous forest vehicles (which can be regarded as logical developments in the ongoing automation of forest machines), the systems that could be applied in them, their potential advantages and their limitations (in the foreseeable future) are considered here. The aims were to analyse: (1) the factors influencing the degree of automation in logging; (2) the technical principles that can be applied to autonomous forest machines, and (3) the feasibility of developing an autonomous path-tracking forest vehicle. A class of such vehicles that are believed to have considerable commercial potential is autonomous wood shuttles (forwarders). The degree of automation is influenced by increased productivity, the machine operator as a bottle-neck, cost reduction, and environmental aspects. Technical principles that can be applied to autonomous forest vehicles are satellite navigation, laser odometry, wheel odometry, laser scanner and radar. The presented system has demonstrated both possibilities and difficulties associated with autonomous forest machines. It is in a field study shown that it is quite possible for them to learn and track a path previously demonstrated by an operator with an accuracy of 0.1m on flat ground. A new pathtracking algorithm has been developed to reduce deviations by utilizing the driver’s steering commands.
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