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| 2. |
- Elsik, Christine G., et al.
(författare)
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The Genome Sequence of Taurine Cattle : A Window to Ruminant Biology and Evolution
- 2009
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 324:5926, s. 522-528
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Tidskriftsartikel (refereegranskat)abstract
- To understand the biology and evolution of ruminants, the cattle genome was sequenced to about sevenfold coverage. The cattle genome contains a minimum of 22,000 genes, with a core set of 14,345 orthologs shared among seven mammalian species of which 1217 are absent or undetected in noneutherian (marsupial or monotreme) genomes. Cattle-specific evolutionary breakpoint regions in chromosomes have a higher density of segmental duplications, enrichment of repetitive elements, and species-specific variations in genes associated with lactation and immune responsiveness. Genes involved in metabolism are generally highly conserved, although five metabolic genes are deleted or extensively diverged from their human orthologs. The cattle genome sequence thus provides a resource for understanding mammalian evolution and accelerating livestock genetic improvement for milk and meat production.
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| 3. |
- Birney, Ewan, et al.
(författare)
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Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project
- 2007
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 447:7146, s. 799-816
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Tidskriftsartikel (refereegranskat)abstract
- We report the generation and analysis of functional data from multiple, diverse experiments performed on a targeted 1% of the human genome as part of the pilot phase of the ENCODE Project. These data have been further integrated and augmented by a number of evolutionary and computational analyses. Together, our results advance the collective knowledge about human genome function in several major areas. First, our studies provide convincing evidence that the genome is pervasively transcribed, such that the majority of its bases can be found in primary transcripts, including non-protein-coding transcripts, and those that extensively overlap one another. Second, systematic examination of transcriptional regulation has yielded new understanding about transcription start sites, including their relationship to specific regulatory sequences and features of chromatin accessibility and histone modification. Third, a more sophisticated view of chromatin structure has emerged, including its inter-relationship with DNA replication and transcriptional regulation. Finally, integration of these new sources of information, in particular with respect to mammalian evolution based on inter- and intra-species sequence comparisons, has yielded new mechanistic and evolutionary insights concerning the functional landscape of the human genome. Together, these studies are defining a path for pursuit of a more comprehensive characterization of human genome function.
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| 5. |
- Kallenius, G, et al.
(författare)
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Pneumococcal bacteraemia in Sweden
- 1997
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Ingår i: Lancet (London, England). - 0140-6736. ; 349:9069, s. 1910-1910
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 7. |
- Allwood, Jens, 1947, et al.
(författare)
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Några frekvensbaserade skillnder mellan svenskt och danskt talsspråk
- 2003
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Ingår i: In: P. Juel Henrichsen (ed.). Babylonic Confusion Resolved. Proceedings of the Nordic Symposium on the Comparison of Spoken Languages at SMOL (CBS). Copenhagen Working Papers in LSP.. ; 1, s. 68-98
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Tidskriftsartikel (refereegranskat)
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| 8. |
- Henrichsen, P. J., et al.
(författare)
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Swedish and Danish, spoken and written language : A statistical comparison
- 2005
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Ingår i: International Journal of Corpus Linguistics. - 1384-6655 .- 1569-9811. ; 10:3, s. 367-399
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Tidskriftsartikel (refereegranskat)abstract
- The aim of much linguistic research is to determine the grammar and the lexicon of a certain language L. The spoken variant of L - in so far as it is considered at all - is generally taken to be just another projection of the same grammar and lexicon. We suspect that this assumption may be wrong. Our suspicion derives from our contrastive analyses of four corpora, two Swedish and two Danish (covering spoken as well as written language), suggesting that - in the dimensions of frequency distribution, word type selection, and distribution over parts of speech - the mode of communication (spoken versus written) is much more significant as a determining factor than even the choice of language (Swedish versus Danish). ©John Benjamins Publishing Company.
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| 9. |
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| 10. |
- Malm, Gunilla, et al.
(författare)
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Reproductive function during summer and winter in Norwegian men living north and south of the Arctic circle.
- 2004
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Ingår i: Journal of Clinical Endocrinology and Metabolism. - : The Endocrine Society. - 1945-7197 .- 0021-972X. ; 89:9, s. 4397-4402
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Tidskriftsartikel (refereegranskat)abstract
- Seasonal, daylight-dependent variation in human spermatozoa counts, with lowest values during summer, has been suggested. To test this hypothesis, we performed a longitudinal study of semen quality and reproductive hormone levels in Norwegian men living north and south of the Arctic Circle. An ejaculate and a serum specimen were obtained both in summer and in winter from 92 volunteers in Tromsoe (69° north latitude) and 112 in Oslo (60° north latitude). Semen analyses were performed, and serum was assayed for FSH and inhibin B. The median spermatozoa concentration in Tromsoe after adjustment for abstinence period length was 49 × 106/ml in summer and 54 × 106/ml in winter. Corresponding values for Oslo were 59 × 106/ml and 54 × 106/ml. The seasonal differences in spermatozoa concentration were not statistically significant, nor were significant differences observed in median total spermatozoa count, semen volume, percentage progressive motile spermatozoa, or FSH. In Tromsoe, but not Oslo, inhibin B concentration was slightly, but significantly (P = 0.02) higher in winter than summer (229 ng/liter vs. 223 ng/liter).The length of the daylight period may have a slight impact on hormonal markers of spermatogenesis but does not cause substantial changes in spermatozoa numbers and motility.
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