| 1. |
- Mihnea, Mihaela, 1983-, et al.
(författare)
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Effect of Pre-Fermentative Strategieson the Composition of Prieto Picudo (Vitis vinífera) Red Wines
- 2016
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Ingår i: OALib Journal. - : Open Access Library (OALib). - 2333-9705 .- 2333-9721. ; 3
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Tidskriftsartikel (refereegranskat)abstract
- The actual wine global market presents the risk of standardization of the wines and the losses of wine grape peculiarities. To combat this fact, autochthonous wine grapes are extremely interesting to use for winemaking. The use of the pre-fermentative maceration technique in autochthonous grape varieties could be an alternative of increasing their complexity. The aim of the present work was to compare the effect of five different pre-fermentative maceration treatments on the colour, phenolic and volatile composition of Prieto Picudo (PP) autochthonous red wines. The evolution during 12 months of the different wines was also studied for one vintage. Enzymatic, refrigerate and cryo-maceration treatments were applied to PP autochthonous grape varieties. The study was carried out during two consecutive vintages. Results showed that enzymatic maceration was the most effective treatment to improve levels of phenols, colour intensity and volatile compounds. Cold maceration showed also good effects. However, it was not able to improve the extractive effects of enzymatic macerations. Generally, wines obtained with pre-fermentative maceration techniques showed better colour and volatile stability than control wines.
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| 2. |
- Gatica-Ortega, María Elena, et al.
(författare)
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Nonoccupational Allergic Contact Dermatitis to 4-Acryloylmorpholine in Smartwatch Screen Protectors Glue
- 2022
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Ingår i: Dermatitis. - 1710-3568. ; 33:6, s. 429-434
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Tidskriftsartikel (refereegranskat)abstract
- Background We recently identified an outbreak of occupational allergic contact dermatitis (ACD) involving workers of a Spanish company selling smartphone protective cases from a glue product. A chemical analysis of one glue sample revealed the presence of 4-acryloylmorpholine among other allergens. The same glue is also used to attach tempered glass protective cases to Apple smartwatches. Objective Our objective was to describe a case series of nonoccupational consumer ACD from the previously mentioned Apple smartwatch protective case glue. Methods We evaluated epidemiological and clinical data, as well as patch tests results. Results Three women were diagnosed with nonoccupational ACD from the adhesive. An annular vesicular inflammatory plaque involving the dorsal aspect of the wrist was initially observed in all. Two of the 3 patients were patch tested with 4-acryloylmorpholine 0.5% with positive strong reactions. Both also strongly reacted to a sample of the glue semiopen tested in a drop of petrolatum. One of them was also positive for various acrylates. Conclusions 4-Acryloylmorpholine has been identified in an adhesive used to attach protective cases to smartwatches. Nonoccupational ACD have been described to involve consumers of smartwatches. A UV-curable adhesive used to attach protective cases to smartwatches has been considered to be the culprit.
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| 3. |
- Herreros-Montejano, Francisca, et al.
(författare)
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Outbreak of occupational allergic contact dermatitis from a smartphone screen protector glue
- 2022
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Ingår i: Contact Dermatitis. - : Wiley. - 0105-1873 .- 1600-0536. ; 87:1, s. 53-61
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Tidskriftsartikel (refereegranskat)abstract
- Background: Sensitization to acrylates is a concern in the occupational/environmental dermatology field. Objective: To describe an occupational allergic contact dermatitis (ACD) outbreak from a smartphone screen protector glue. Methods: Thirteen affected workers of a chain store selling phone screen protectors were investigated in five Spanish dermatology departments. The glue datasheet and label were assessed. A chemical analysis of the glue was performed. Based on this, some patients underwent additional testing. Results: All patients (all female, mean age: 25) had severe fingertip dermatitis. The datasheet/label indicated that the glue contained isobornyl acrylate (IBOA), a “photoinitiator” and polyurethane oligomer. The company informed us that the ingredients were polyurethane acrylate, “methacrylate” (unspecified), acrylic acid, hydroxyethyl methacrylate, propylmethoxy siloxane, and photoinitiator 184. Isobornyl acrylate (or IBOA) and N,N-dimethylacrylamide (DMAA) were patch tested in eight and two cases, respectively, with negative results. A chemical analysis revealed 4-acryloylmorpholine (ACMO); isobornyl methacrylate (IBMA), and lauryl acrylate in one glue sample. Seven patients were patch tested with dilutions of the identified substances and six of seven were positive for ACMO 0.5% pet. Conclusion: An outbreak of occupational ACD, likely from ACMO in a glue is described. Further investigations are needed to corroborate the role played by each compound identified in the chemical analyses.
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| 4. |
- Krauss, Tobias, et al.
(författare)
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Preventive medicine of von Hippel-Lindau disease-associated pancreatic neuroendocrine tumors
- 2018
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Ingår i: Endocrine-Related Cancer. - : BIOSCIENTIFICA LTD. - 1351-0088 .- 1479-6821. ; 25:9, s. 783-793
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Tidskriftsartikel (refereegranskat)abstract
- Pancreatic neuroendocrine tumors (PanNETs) are rare in von Hippel-Lindau disease (VHL) but cause serious morbidity and mortality. Management guidelines for VHL-PanNETs continue to be based on limited evidence, and survival data to guide surgical management are lacking. We established the European-American-Asian-VHL-PanNET-Registry to assess data for risks for metastases, survival and long-term outcomes to provide best management recommendations. Of 2330 VHL patients, 273 had a total of 484 PanNETs. Median age at diagnosis of PanNET was 35 years (range 10-75). Fifty-five (20%) patients had metastatic PanNETs. Metastatic PanNETs were significantly larger (median size 5 vs 2 cm; P < 0.001) and tumor volume doubling time (TVDT) was faster (22 vs 126 months; P = 0.001). All metastatic tumors were >= 2.8 cm. Codons 161 and 167 were hotspots for VHL germline mutations with enhanced risk for metastatic PanNETs. Multivariate prediction modeling disclosed maximum tumor diameter and TVDT as significant predictors for metastatic disease (positive and negative predictive values of 51% and 100% for diameter cut-off >= 2.8 cm, 44% and 91% for TVDT cut-off of <= 24 months). In 117 of 273 patients, PanNETs > 1.5 cm in diameter were operated. Ten-year survival was significantly longer in operated vs non-operated patients, in particular for PanNETs < 2.8 cm vs >= 2.8 cm (94% vs 85% by 10 years; P = 0.020; 80% vs 50% at 10 years; P = 0.030). This study demonstrates that patients with PanNET approaching the cut-off diameter of 2.8 cm should be operated. Mutations in exon 3, especially of codons 161/167 are at enhanced risk for metastatic PanNETs. Survival is significantly longer in operated non-metastatic VHL-PanNETs.
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| 5. |
- Carsin, Anne-Elie, et al.
(författare)
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Spirometric patterns in young and middle-aged adults : a 20-year European study
- 2024
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Ingår i: Thorax. - : BMJ Publishing Group Ltd. - 0040-6376 .- 1468-3296. ; 79:2, s. 153-162
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Tidskriftsartikel (refereegranskat)abstract
- Background Understanding the natural history of abnormal spirometric patterns at different stages of life is critical to identify and optimise preventive strategies. We aimed to describe characteristics and risk factors of restrictive and obstructive spirometric patterns occurring before 40 years (young onset) and between 40 and 61 years (mid-adult onset). Methods We used data from the population- based cohort of the European Community Respiratory Health Survey (ECRHS). Prebronchodilator forced expiratory volume in one second (FEV 1) and forced vital capacity (FVC) were assessed longitudinally at baseline (ECRHS1, 1993-1994) and again 20 years later ( ECRHS3, 2010-2013). Spirometry patterns were defined as: restrictive if FEV1/ FVC >= LLN and FVC<10th percentile, obstructive if FEV1/FVC
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| 6. |
- Dolcemascolo, Roswitha, et al.
(författare)
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Repurposing the mammalian RNA-binding protein Musashi-1 as an allosteric translation repressor in bacteria
- 2024
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Ingår i: eLIFE. - : eLife Sciences Publications Ltd. - 2050-084X. ; 12
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Tidskriftsartikel (refereegranskat)abstract
- The RNA recognition motif (RRM) is the most common RNA-binding protein domain identified in nature. However, RRM-containing proteins are only prevalent in eukaryotic phyla, in which they play central regulatory roles. Here, we engineered an orthogonal post-transcriptional control system of gene expression in the bacterium Escherichia coli with the mammalian RNA-binding protein Musashi-1, which is a stem cell marker with neurodevelopmental role that contains two canonical RRMs. In the circuit, Musashi-1 is regulated transcriptionally and works as an allosteric translation repressor thanks to a specific interaction with the N-terminal coding region of a messenger RNA and its structural plasticity to respond to fatty acids. We fully characterized the genetic system at the population and single-cell levels showing a significant fold change in reporter expression, and the underlying molecular mechanism by assessing the in vitro binding kinetics and in vivo functionality of a series of RNA mutants. The dynamic response of the system was well recapitulated by a bottom-up mathematical model. Moreover, we applied the post-transcriptional mechanism engineered with Musashi-1 to specifically regulate a gene within an operon, implement combinatorial regulation, and reduce protein expression noise. This work illustrates how RRM-based regulation can be adapted to simple organisms, thereby adding a new regulatory layer in prokaryotes for translation control.
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| 7. |
- Galafassi, Diego, et al.
(författare)
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‘Raising the temperature’ : the arts on a warming planet
- 2018
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Ingår i: Current Opinion in Environmental Sustainability. - : Elsevier BV. - 1877-3435 .- 1877-3443. ; 31, s. 71-79
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Forskningsöversikt (refereegranskat)abstract
- The search for decisive actions to remain below 1.5 °C of global temperature rise will require profound cultural transformations. Yet our knowledge of how to promote and bring about such deep transformative changes in the minds and behaviours of individuals and societies is still limited. As climate change unravels and the planet becomes increasingly connected, societies will need to articulate a shared purpose that is both engaging and respectful of cultural diversity. Thus, there is a growing need to ‘raise the temperature’ of integration between multiple ways of knowing climate change. We have reviewed a range of literatures and synthesized them in order to draw out the perceived role of the arts in fostering climate transformations. Our analysis of climate-related art projects and initiatives shows increased engagement in recent years, particularly with the narrative, visual and performing arts. The arts are moving beyond raising awareness and entering the terrain of interdisciplinarity and knowledge co-creation. We conclude that climate-arts can contribute positively in fostering the imagination and emotional predisposition for the development and implementation of the transformations necessary to address the 1.5 °C challenge.
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| 8. |
- Galafassi, Diego, et al.
(författare)
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Restoring our senses, restoring the Earth. Fostering imaginative capacities through the Arts for envisioning climate transformations
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Ingår i: Elementa. - 2325-1026.
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Tidskriftsartikel (refereegranskat)abstract
- Humanity has never lived in a world where global average temperature is above two degrees of current levels. Moving towards such High-End Climate Change (HECC) futures is likely to involve high uncertainty, non-linear dynamics in global ecologies and a fundamental challenge to current governance structures. Responding to such a world will require more than technical and conventional solutions. We depart in this paper from the notion that human imagination may be a central capacity to support multiple learning processes necessary in triggering transformative change. We developed a three-years long art-based approach to knowledge co-creation We explore the possibilities of fostering with the intention to boost imaginative capacities in support to the development of transformative societal visions. The process combines a range of performative, visual and reflexive practices with the ambition to reach out to more-than-rational but also practical elements of future visioning processes. The empirical case was realized alongside a science-led participatory knowledge co-creation process within the EU project IMPRESSIONS, in the Iberian Peninsula. Our analysis focuses on the ways in which this art-based approach brought new ways of seeing, feeling and interpreting the world given the present climate challenge. The approach supported participants in the development of a sensibility towards the future and suggested ways in which the future can be made present in order to empower and infuse action.
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| 9. |
- Galafassi, Diego, et al.
(författare)
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Restoring our senses, restoring the Earth. Fostering imaginative capacities through the arts for envisioning climate transformations
- 2018
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Ingår i: Elementa. - : University of California Press. - 2325-1026. ; 6
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Tidskriftsartikel (refereegranskat)abstract
- Humanity has never lived in a world of global average temperature above two degrees of current levels. Moving towards such High-End Climate Change (HECC) futures presents fundamental challenges to current governance structures and involves the need to confront high uncertainties, non-linear dynamics and multiple irreversibilities in global social-ecological systems. In order to face HECC, imaginative practices able to support multiple ways of learning about and experiencing the future are necessary. In this article we analysed a set of arts-based activities conducted within the five-year EU-funded project IMPRESSIONS aimed at identifying transformative strategies to high-end climate change. The exploratory artistic activities were carried out alongside a science-led participatory integrated assessment process with stakeholders from the Iberian Peninsula. Our arts-based approach combined a range of performative, visual and reflexive practices with the ambition to reach out to more-than-rational but also practical elements of HECC futures. Our study suggests that the arts-based approach helped to bring out new ways of seeing, feeling and interpreting the world which may support the development of individual and collective sensibilities needed to address HECC.
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| 10. |
- García-Martín, Noemi, et al.
(författare)
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Sugar reduction in musts with nanofiltration membranes to obtain low alcohol-content wines
- 2010
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Ingår i: Separation and Purification Technology. - : Elsevier. - 1383-5866 .- 1873-3794. ; 76:2, s. 158-170
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Tidskriftsartikel (refereegranskat)abstract
- Our aim here is to study the sugar reduction in musts to obtain wines with a slight alcohol reduction by nanofiltration. Specifically, sugar reduction is achieved by two successive nanofiltration steps. To test the method, we have worked with two types of musts: a white must from Verdejo grapes and a red one from Tinta de Toro grapes. The musts obtained from the nanofiltration treatment have been mixed with untreated must or with the retentate of the first nanofiltration stage in a proportion adequate to reduce the alcohol content of the resulting wines by 2 degrees.To verify the effectiveness of the process, each of these musts has been fermented along with an untreated control sample of the same must. The alcohol reduction in the wines has been satisfactory. However, a slight loss in the color and aroma of some compounds has been detected. (C) 2010 Elsevier B.V. All rights reserved.
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