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Sökning: WFRF:(Hertogs K)

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  • Lennerstrand, Johan, et al. (författare)
  • Correlation between viral resistance to zidovudine and resistance at the reverse transcriptase level for a panel of human immunodeficiency virus type 1 mutants
  • 2001
  • Ingår i: Journal of Virology. - 0022-538X .- 1098-5514. ; 75:15, s. 7202-7205
  • Tidskriftsartikel (refereegranskat)abstract
    • Using a large panel of human immunodeficiency virus type 1 site-directed mutants, we have observed a higher correlation than has previously been demonstrated between zidovudine (AZT)-triphosphate resistance data at the reverse transcriptase (RT) level and corresponding viral AZT resistance. This enhanced-resistance effect at the RT level was seen with ATP and to a lesser extent with PP(i) when ATP was added at physiological concentrations. The ATP-dependent mechanism (analogous to pyrophosphorolysis) appears to be dominant in the mutants bearing the D67N and K70R or 69 insertion mutations, whereas the Q151M mutation seems independent of ATP for decreased binding to AZT-triphosphate.
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3.
  • Ortega-Hertogs, R. J., et al. (författare)
  • Coexistence of various Nd-rich and Fe-rich Fe-Nd short range orderings in bulk glassy Nd60Fe30Al10 hard magnets
  • 2001
  • Ingår i: Materials transactions. - : Japan Institute of Metals. - 1345-9678 .- 1347-5320. ; 42:8, s. 1547-1551
  • Tidskriftsartikel (refereegranskat)abstract
    • Bulk Nd60Fe30Al10 metallic glasses are found to exhibit a complex magnetic behavior at very low temperatures related to the coexistence of various Nd-rich and Fe-rich magnetic short range orderings, as evidenced by AC-susceptibility studies in combination with hysteretic loops at fields up to 30 T. Above 80 K the magnetic behavior is shown to correlate with Stoner-Wohlfarth hysteresis loops with pronounced thermal activation effects. These observations suggest the existence of an Fe-rich Fe-Nd hard magnetic 'phase' formed by an ensemble of randomly oriented uniaxial magnetic nanoentities embedded in a Nd-rich matrix. The exchange coupling and development of a large axial crystal field anisotropy at very low temperatures and the uncoupling above 70 K of the Fe-rich Fe-Nd hard magnetic phase to the Nd-rich matrix appears to be at the origin of the observed overall magnetic behavior.
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