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- Heshmati, Y, et al.
(författare)
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The histone chaperone NAP1L3 is required for haematopoietic stem cell maintenance and differentiation
- 2018
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Ingår i: Scientific reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 8:1, s. 11202-
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Tidskriftsartikel (refereegranskat)abstract
- Nucleosome assembly proteins (NAPs) are histone chaperones with an important role in chromatin structure and epigenetic regulation of gene expression. We find that high gene expression levels of mouse Nap1l3 are restricted to haematopoietic stem cells (HSCs) in mice. Importantly, with shRNA or CRISPR-Cas9 mediated loss of function of mouse Nap1l3 and with overexpression of the gene, the number of colony-forming cells and myeloid progenitor cells in vitro are reduced. This manifests as a striking decrease in the number of HSCs, which reduces their reconstituting activities in vivo. Downregulation of human NAP1L3 in umbilical cord blood (UCB) HSCs impairs the maintenance and proliferation of HSCs both in vitro and in vivo. NAP1L3 downregulation in UCB HSCs causes an arrest in the G0 phase of cell cycle progression and induces gene expression signatures that significantly correlate with downregulation of gene sets involved in cell cycle regulation, including E2F and MYC target genes. Moreover, we demonstrate that HOXA3 and HOXA5 genes are markedly upregulated when NAP1L3 is suppressed in UCB HSCs. Taken together, our findings establish an important role for NAP1L3 in HSC homeostasis and haematopoietic differentiation.
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| 4. |
- Agah, Shahram, et al.
(författare)
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Systematic review with meta-analysis: Effects of probiotic supplementation on symptoms in functional dyspepsia
- 2020
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Ingår i: Journal of Functional Foods. - : Elsevier BV. - 1756-4646. ; 68
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Forskningsöversikt (refereegranskat)abstract
- The pathophysiology of functional dyspepsia (FD) remains poorly understood, but alterations of the small intestinal microbiome have been observed. The place of probiotics in treatment is uncertain. We performed a systematic review and meta-analysis of the currently available randomized, controlled trials (RCTs) to evaluate the potential beneficial effects and risks of probiotics in FD. Pubmed, EMBASE, Scopus, Web of Science and the Cochrane Controlled Trials Register were searched (up to May 2019) for RCTs evaluating the effects of probiotic supplementation compared to placebo in adults with FD. Two reviewers independently assessed eligibility, trial quality and extracted information from identified articles. To compare the effects of probiotics with placebo, risk ratios (RRs) with 95% confidence intervals (CIs) were pooled using random effects models. Six trials, including 422 participants were included but only three RCTs could be included in the meta-analysis. Lactobacillus strains showed potential positive effects in terms of improving upper gastrointestinal (GI) symptoms in patients with FD. Probiotic supplementation tended to improve global dyspepsia score (n = 3 RCTs, risk ratio [RR]: 1.35, 95% CI 0.99 to 1.84; P = 0.061) and bacterial composition in the GI tract. Probiotics were well tolerated without any serious adverse events. While the available data suggest that supplementation with probiotics may improve GI symptoms in patients with FD, the evidence is insufficient to draw clear conclusions regarding efficacy. Thus, high-quality RCTs are needed to establish the beneficial effects of probiotic supplementation on FD outcomes.
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| 5. |
- Al-mutawkkil, A., et al.
(författare)
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Development of telecommunication and broadcasting infrastructure indices at the global level
- 2009
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Ingår i: Telecommunications Policy. - : Elsevier BV. - 0308-5961 .- 1879-3258. ; 33:3-4, s. 176-199
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Tidskriftsartikel (refereegranskat)abstract
- The importance of information and communication technology (ICT) in economic development has been increasing rapidly along with the Internet and mobile telecommunication networks. ICT development is becoming a main growth factor of many countries. As they realize the importance of the ICT industry, developing nations work to catch up with established economies. Therefore, many nations are formulating an ICT-enhanced policy. This paper introduces a number of telecommunication and broadcasting sub-indices, which include the fixed telephone network, the Internet, and mobile networks, which are aggregated into a composite Telecommunication Index (TI). The indices are computed using principal component analysis and human development type index methods. The country rankings, by different ICT-related indices, help identify the strengths and weaknesses of infrastructure development such that each country can foster economic growth. The performance of TI is compared with several other indices, such as the digital access, human development, and ArCo technology indices. The type of indices affects the country ratings. Results suggest that the parametric index approach may be preferred over those methods in which the subjective weighted summation of normalized variables used (non-parametric indices). Crown Copyright © 2009.
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| 6. |
- Bechlioulis, Charalampos P., et al.
(författare)
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Robust Image-Based Visual Servoing With Prescribed Performance Under Field of View Constraints
- 2019
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Ingår i: IEEE Transactions on robotics. - : Institute of Electrical and Electronics Engineers (IEEE). - 1552-3098 .- 1941-0468. ; 35:4, s. 1063-1070
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Tidskriftsartikel (refereegranskat)abstract
- In this paper, we propose a visual servoing scheme that imposes predefined performance specifications on the image feature coordinate errors and satisfies the visibility constraints that inherently arise owing to the camera's limited field of view, despite the inevitable calibration and depth measurement errors. Its efficiency is demonstrated via comparative experimental and simulation studies.
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| 7. |
- Bechlioulis, C. P., et al.
(författare)
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Sensor-based motion control of autonomous underwater vehicles, part II : Robust motion control strategies
- 2020
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Ingår i: Autonomous Underwater Vehicles. - : Institution of Engineering and Technology (IET). ; , s. 45-78
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- The first section of this chapter presents an NMPC strategy for underwater robotic vehicles operating under various constraints. The purpose of the controller is to guide the vehicle towards specific way -points. Various constraints such as obstacles, workspace boundaries and control input saturation as well as predefined upper bound of the vehicle velocity (requirements for several underwater tasks such as seabed inspection scenario and mosaicking) are considered during the control design. The proposed scheme incorporates the full dynamics of the vehicle in which the ocean currents are also involved. The controller is designed in order to find the optimal thrusts required for minimizing the way -point tracking error. Moreover, the controlinputs calculated by the proposed approach are formulated in a way that the vehicle will exploit the ocean currents, when they are in favor of the way -point tracking mission, which results in reduced energy consumption by the thrusters. In the second part of this chapter, novel position- and trajectory -tracking control schemes for AUVs are presented. The proposed controllers do not utilize the vehicle’s dynamic model parameters and guarantee prescribed transient and steady-state performance despite the presence of external disturbances and kinematic constraints for the case of underactuated vehicles. Moreover, through the appropriate selection of certain performance functions, the proposed scheme can also guarantee the satisfaction of motion and performance constraints imposed by the desired task.
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| 8. |
- Eqtami, A., et al.
(författare)
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Self-triggered model predictive control for nonholonomic systems
- 2013
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Ingår i: 2013 European Control Conference, ECC 2013. - : IEEE. - 9783033039629 ; , s. 638-643
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Konferensbidrag (refereegranskat)abstract
- This paper proposes a Model Predictive Control (MPC) framework combined with a self-triggering mechanism for constrained uncertain systems. Under the proposed scheme, the control input as well as the next control update time are provided at each triggering instant. Between two consecutive triggering instants, the control trajectory given by the MPC is applied to the plant in an open-loop fashion. This results to less frequent computations while preserving stability and convergence of the closed-loop system. A scenario for the stabilization of a nonholonomic robot subject to constraints and disturbances is considered, with the aim of reaching a specific triggering mechanism. The robot under the proposed control framework is driven to a compact set where it is ultimately bounded. The efficiency of the proposed approach is illustrated through a simulated example.
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| 9. |
- Eqtami, A., et al.
(författare)
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Self-triggered model predictive control framework for the cooperation of distributed nonholonomic agents
- 2013
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Ingår i: 2013 IEEE 52nd Annual Conference on Decision and Control (CDC). - : IEEE conference proceedings. - 9781467357173 ; , s. 7384-7389
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Konferensbidrag (refereegranskat)abstract
- In this paper we propose a decentralized Model Predictive Control (MPC) framework with a self-triggering mechanism, for a team of cooperating agents. The nonholonomic agents are controlled locally and exchange information with their neighbors. The aim at scheduling the control updates based on a self-triggering criterion is twofold: To reduce the updates of the control law for each agent and to reduce the communication effort between the agents. The input-to-state (abbr. ISS) stability of the agents is proven, the condition for triggering is provided and the theoretic results are then depicted by a simulated example.
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