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- Elmberg, Johan, 1960-, et al.
(författare)
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Seabird migration at Cabo Carvoeiro (Peniche, Portugal) in autumn 2015
- 2020
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Ingår i: Marine Ornithology. - 1018-3337 .- 2074-1235. ; 48:2, s. 231-244
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Tidskriftsartikel (refereegranskat)abstract
- Land-based counts at Cabo Carvoeiro (Peniche, Portugal), made between 15 August and 15 November 2015 (effort 90 d, 517 h), tallied302 469 birds, most of which (99.98%) were southbound. Although 65 species were observed, four species contributed to 91% of the total:207 608 Northern Gannet Morus bassanus, 32281 Cory’s Shearwater Calonectris borealis, 16086 Manx Shearwater Puffinus puffinus,and 15 222 Balearic Shearwater Puffinus mauretanicus. Passage as a whole increased throughout the period, mainly due to a gradualintensification of Northern Gannet migration. More than 67 000 southbound procellariforms of 12 species were recorded, as were 6183Stercorariidae of four species. Daily passage rates of species recorded on more than 68 d were positively correlated in 22 of 36 cases.For Northern Gannet and Mediterranean Gull Ichthyaetus melanocephalus, the proportion of adult birds increased steadily, outnumberingyounger birds. Extrapolation based on counted versus uncounted daylight hours suggests that at least 415000 Northern Gannets, 65000Cory’s Shearwaters, and 30000 Balearic Shearwaters passed south at Cabo Carvoeiro in autumn 2015. Clearly, a very large share of theglobal population of the endangered Balearic Shearwater can be monitored at Cabo Carvoeiro. Based on generally unidirectional passagepatterns, high species diversity, as well as high season totals and daily passage rates of several species, Cabo Carvoeiro is one of the mostpromising mainland sites in the eastern North Atlantic to monitor a wide range of seabirds.
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- Mallet, E, et al.
(författare)
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A liquid hexavalent combined vaccine against diphtheria, tetanus, pertussis, poliomyelitis, Haemophilus influenzae type B and hepatitis B: review of immunogenicity and safety
- 2004
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Ingår i: Vaccine. - : Elsevier BV. - 1873-2518 .- 0264-410X. ; 22:11-12, s. 1343-1357
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Forskningsöversikt (refereegranskat)abstract
- To reduce the number of injections needed to comply with paediatric vaccination requirements, a liquid, hexavalent vaccine (DTaP-IPV-PRP-T-HBs; Hexavac((R)); Aventis Pasteur MSD) has been developed for primary and booster vaccination of infants and toddlers. In extensive clinical studies, Hexavac((R)) has been shown to be highly immunogenic. Seroconversion or seroprotective titres of antibodies against all antigens were achieved in the majority of infants following a primary series of three doses administered at 1-2-month intervals from 2 months of age. Hexavac((R)) also induced immunologic memory, as evidenced by the anamnestic response to booster vaccination at 12-18 months of age. These responses were comparable with those seen following concomitant administration of Pentavac(TM) (DTaP-IPV//PRP-T) and monovalent hepatitis B vaccine (H-B-Vax(TM) II), and were also within the ranges observed for other relevant licensed vaccines. Clinical studies comparing the immunogenicity of Hexavac((R)) administered at either 2, 3 and 4 months or 2, 4 and 6 months demonstrated that it can be used by either vaccination schedule. A further study also supported the use of primary doses of Hexavac((R)) at 3 and 5 months with a booster at 12 months of age. Hexavac((R)) demonstrated a good reactogenicity and tolerability profile. The most frequently reported adverse events after both primary and booster doses were local reactions of redness and swelling/induration and a systemic response of mild fever, irrespective of the vaccine used for priming. Hexavac((R)) provided immunity against six important childhood diseases with a single injection at each visit. (C) 2003 Elsevier Ltd. All rights reserved.
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- Zhou, T. K., et al.
(författare)
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Molecular Characterisation of Titin N2A and Its Binding of CARP Reveals a Titin/Actin Cross-linking Mechanism
- 2021
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Ingår i: Journal of Molecular Biology. - : Elsevier BV. - 0022-2836. ; 433:9
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Tidskriftsartikel (refereegranskat)abstract
- Striated muscle responds to mechanical overload by rapidly up-regulating the expression of the cardiac ankyrin repeat protein, CARP, which then targets the sarcomere by binding to titin N2A in the I-band region. To date, the role of this interaction in the stress response of muscle remains poorly understood. Here, we characterise the molecular structure of the CARP-receptor site in titin (UN2A) and its binding of CARP. We find that titin UN2A contains a central three-helix bundle fold (ca 45 residues in length) that is joined to N- and C-terminal flanking immunoglobulin domains by long, flexible linkers with partial helical content. CARP binds titin by engaging an a-hairpin in the three-helix fold of UN2A, the C-terminal linker sequence, and the BC loop in Ig81, which jointly form a broad binding interface. Mutagenesis showed that the CARP/N2A association withstands sequence variations in titin N2A and we use this information to evaluate 85 human single nucleotide variants. In addition, actin co-sedimentation, co-transfection in C2C12 cells, proteomics on heart lysates, and the mechanical response of CARP-soaked myofibrils imply that CARP induces the cross-linking of titin and actin myofilaments, thereby increasing myofibril stiffness. We conclude that CARP acts as a regulator of force output in the sarcomere that preserves muscle mechanical performance upon overload stress. Crown Copyright (C) 2021 Published by Elsevier Ltd. All rights reserved.
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