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- Waldorf, Kristina M. Adams, et al.
(författare)
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Congenital Zika virus infection as a silent pathology with loss of neurogenic output in the fetal brain
- 2018
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Ingår i: Nature Medicine. - : Springer Science and Business Media LLC. - 1078-8956 .- 1546-170X. ; 24:3, s. 368-374
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Tidskriftsartikel (refereegranskat)abstract
- Zika virus (ZIKV) is a flavivirus with teratogenic effects on fetal brain, but the spectrum of ZIKV-induced brain injury is unknown, particularly when ultrasound imaging is normal. In a pregnant pigtail macaque (Macaca nemestrina) model of ZIKV infection, we demonstrate that ZIKV-induced injury to fetal brain is substantial, even in the absence of microcephaly, and may be challenging to detect in a clinical setting. A common and subtle injury pattern was identified, including (i) periventricular T2-hyperintense foci and loss of fetal noncortical brain volume, (ii) injury to the ependymal epithelium with underlying gliosis and (iii) loss of late fetal neuronal progenitor cells in the subventricular zone (temporal cortex) and subgranular zone (dentate gyrus, hippocampus) with dysmorphic granule neuron patterning. Attenuation of fetal neurogenic output demonstrates potentially considerable teratogenic effects of congenital ZIKV infection even without microcephaly. Our findings suggest that all children exposed to ZIKV in utero should receive long-term monitoring for neurocognitive deficits, regardless of head size at birth.
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3. |
- Yusuf, D, et al.
(författare)
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The transcription factor encyclopedia
- 2012
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Ingår i: Genome biology. - : Springer Science and Business Media LLC. - 1474-760X .- 1465-6906. ; 13:3, s. R24-
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Tidskriftsartikel (refereegranskat)
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4. |
- Sjöström, Jonas, et al.
(författare)
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Privacy and Accountability in Online Communities : Towards a Theory of Scrutiny
- 2014
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Ingår i: DESIGN SCIENCE. - 9783319139364 - 9783319139357 ; , s. 41-51
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Konferensbidrag (refereegranskat)abstract
- Information systems design must balance requirements of privacy and accountability for the good of individuals and society. We ground our study in the context of the design and development of a eHealth system for psychosocial care. Multi-level privacy protections are balanced with the need to provide for accountable interventions in well-defined critical care situations. We identify a set of meta-requirements leading towards a theory of scrutiny.
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5. |
- Sjöström, Jonas, 1974-, et al.
(författare)
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Scrutinizing Privacy and Accountability in Online Psychosocial Care
- 2017
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Ingår i: IT Professional Magazine. - 1520-9202 .- 1941-045X. ; 19:3, s. 45-51
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Tidskriftsartikel (refereegranskat)abstract
- The authors' scrutiny-management technique supports managers and IT developers to systematically address privacy and accountability issues when designing software for the online delivery of health servicesspecifically, psychosocial care.
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