| 1. |
- Andersson, Leif, et al.
(författare)
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ZBED6 : the birth of a new transcription factor in the common ancestor of placental mammals
- 2010
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Ingår i: Transcription. - : Informa UK Limited. - 2154-1272 .- 2154-1264. ; 1:3, s. 144-148
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Tidskriftsartikel (refereegranskat)abstract
- A DNA transposon integrated into -the genome of a primitive mammal some 200 million years ago and, millions of years later, it evolved an essential function in the common ancestor of all placental mammals. This protein, now named ZBED6, was recently discovered because a mutation disrupting one of its binding sites, in an intron of the IGF2 gene, makes pigs grow more muscle. These findings have revealed a new mechanism for regulating muscle growth as well as a novel transcription factor that appears to be of major importance for transcriptional regulation in placental mammals.
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| 2. |
- Lundgren, Svante, et al.
(författare)
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Messianska judar
- 2023
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Ingår i: Pilgrimsfärd för rättvis värld : Möten med kyrkorna i Israel och Palestina - Möten med kyrkorna i Israel och Palestina. - 9789198634976 ; , s. 236-237
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Bokkapitel (populärvet., debatt m.m.)
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| 3. |
- Lundgren, Svante, et al.
(författare)
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Vilka är de etiopiska judarna?
- 2023
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Ingår i: Pilgrimsfärd för rättvis värld : Möten med kyrkorna i Israel och Palestina - Möten med kyrkorna i Israel och Palestina. - 9789198634976 ; , s. 170-170
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Bokkapitel (populärvet., debatt m.m.)
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| 4. |
- Andersson, Lisa, et al.
(författare)
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Mutations in DMRT3 affect locomotion in horses and spinal circuit function in mice
- 2012
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 488:7413, s. 642-646
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Tidskriftsartikel (refereegranskat)abstract
- Locomotion in mammals relies on a central pattern-generating circuitry of spinal interneurons established during development that coordinates limb movement(1). These networks produce left-right alternation of limbs as well as coordinated activation of flexor and extensor muscles(2). Here we show that a premature stop codon in the DMRT3 gene has a major effect on the pattern of locomotion in horses. The mutation is permissive for the ability to perform alternate gaits and has a favourable effect on harness racing performance. Examination of wild-type and Dmrt3-null mice demonstrates that Dmrt3 is expressed in the dI6 subdivision of spinal cord neurons, takes part in neuronal specification within this subdivision, and is critical for the normal development of a coordinated locomotor network controlling limb movements. Our discovery positions Dmrt3 in a pivotal role for configuring the spinal circuits controlling stride in vertebrates. The DMRT3 mutation has had a major effect on the diversification of the domestic horse, as the altered gait characteristics of a number of breeds apparently require this mutation.
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| 5. |
- Hjälm, Anna, 1977-
(författare)
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A family landscape : On the geographical distances between elderly parents and adult children in Sweden
- 2011
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- With a background in the ageing of the population and the new challenges facing individuals, families and the welfare state, the aim of this thesis is to analyse the changing family landscape and the geographical distances between elderly parents and adult children. The thesis consists of four empirical studies derived from three different sources of data: In the first paper (Paper I), historical population data is combined with modern register data for two Swedish regions. In the second and third papers, individual-level register data covering the entire Swedish population serves as the empirical starting point. The fourth paper leaves the registers aside and builds upon interviews. Paper I provides an introduction and historical background to the question of intergenerational geographical proximity and distance. The paper analyses intergenerational distances and seeks to compare and discuss the significance of the variations. It is shown that concerning extreme proximity a great decrease has occurred over 200 years, however when it comes to having kin within reach the decrease is less dramatic, and that now, just as then, a majority of elderly parents have an adult child within reach. The article concludes that even though geographical distances between generations vary over time and space, no clear linear trend towards intergenerational geographical separation can be established. In Paper II we analyse some features and trends in intergenerational distances in Sweden. We find that 10% of all elderly parents have at least one child living very close and that a majority, 85%, have an adult child within reach. The study shows no clear trend towards increasing intergenerational separation, but suggests that periods of intense societal restructuring, such urbanisation, can lead to spells of increased intergenerational separation on an aggregated level. Paper III investigates whether, and to what extent, elderly parents and adult children move close to each other. We find that even though the older generation makes up a smaller share of the moves made, when they do move they are more likely to move closer to an adult child. Further, having more than one relative at a destination adds to the attraction, and that older elderly are less likely to move close to a child than younger elderly. One interpretation is that young-old parents serve as a resource for their adult children, while older elderly are more influenced by the need for welfare state based assistance. The last paper, IV, returns to the elderly parents living very close to an adult child. In interviews with 14 elderly the aim of the paper is to gain new understanding about the interaction between intergenerational proximity, assistance and the meaning of being close. Some of the issues raised in the paper relate to migration histories, reciprocity and independence.
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| 6. |
- Hjälm, Anna, 1977-
(författare)
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"Because we know our limits" : Elderly parents' views on intergenerational proximity and intimacy
- 2012
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Ingår i: Journal of Aging Studies. - : Elsevier. - 0890-4065 .- 1879-193X. ; 26:3, s. 296-308
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Tidskriftsartikel (refereegranskat)abstract
- From an intergenerational family perspective, geographical distance and proximity have been shown to affect interaction and the extent of help and support between generations. Geographical separation and nearness hence do not only influence the family per se, but might also concern the welfare state, not least in times of population ageing. This study concerns exchange and assistance between elderly parents living very close to an adult child, and is based on interviews with 14 elderly parents. The interviews revealed that help and support flowed in both directions between the close-living generations, but that from the perspective of the elderly some types of help were more acceptable than others to give and receive. Further, the interviews suggested that living close, albeit discussed as allowing extensive interaction and support, should not be understood as a sign of wanting or even accepting more extensive help from the close-living adult child.
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| 7. |
- Hjälm, Anna, 1977-
(författare)
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Intergenerational proximity and distance over 200 years : examples from two Swedish regions
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- In most Western societies of today populations are ageing, which is expected to pose new challenges to the welfare state. Still, the family might also be affected by an ageing population, if more extensive needs of the elderly cannot be met by the welfare state. For the family, one important factor for managing intergenerational interaction is geographical proximity, and living close has been shown to be a vital prerequisite for help and assistance between elderly parents and adult children. When it comes to the possibility to interact with kin, a common notion has been that as society develops through industrialisation, urbanisation and individualisation, families and kin become less dependent on each other and more spread out geographically, which would challenge their possibilities to offer assistance to each other. In this paper, intergenerational geographical distance in modern and historical times is examined through the unique possibility to combine population register data from six cross-section years stretching from 1820 to 2002. The main finding from the study is that there has been a dramatic decrease over time in generations living extremely close to each other. On the other hand, when it comes to having an adult child within time adjusted daily reach the decline has been much less drastic. Intergenerational geographical distances, beyond the extreme proximity, thus seem to be stable and resilient even though society is changing.
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| 8. |
- Hjälm, Anna, 1977-
(författare)
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The ‘Stayers’ : Dynamics of Lifelong Sedentary Behaviour in an Urban Context
- 2014
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Ingår i: Population, Space and Place. - : John Wiley & Sons. - 1544-8444 .- 1544-8452. ; 20:6, s. 569-580
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Tidskriftsartikel (refereegranskat)abstract
- Migration has, over the years, attracted infinitely more attention than non-migration or staying. In this paper, the focus is set on those individuals who have demonstrated lifelong sedentary behaviour. The aim of the study is to scrutinise the ways in which people who have lived their entire life in the same place make sense of their sedentary, or immobile, lifestyle. The study builds upon semi-structured interviews, conducted in 2011–2012, with persons aged 60 years and older who were living in an urban area in northern Sweden. Initially, the different definitions of staying are highlighted by the informants, and the flexibility of the concept is addressed. The findings indicate that even though reasons for staying might be harder to articulate than reasons for migration, the explanations given are still complex and multi-layered. The findings also suggest that the decision to stay is not a choice made once and then never renegotiated but rather a decision made over and over again. Furthermore, the significance of intertwined lives, both with living relatives and with preceding and following generations, is analysed. Finally, the results from the study challenge earlier pictures of stayers – where they were portrayed as stigmatised – and highlight the need to consider staying, as well as moving, as a conscious choice in order that we may gain a better understanding of the dynamics of staying.
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| 9. |
- Johansson, Jan, et al.
(författare)
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Spider silk proteins and methods for producing spider silk proteins
- 2012
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Patent (övrigt vetenskapligt/konstnärligt)abstract
- The invention provides an isolated major ampullate spidroin protein, which consists of from 150 to 420 amino acid residues and is defined by the formula REP-CT. REP is a repetitive, N-terminally derived protein fragment having from 80 to 300 amino acid residues. CT is a C-terminally derived protein fragment having from 70 to 120 amino acid residues. The invention further provides an isolated fusion protein consisting of a first protein fragment, which is a major ampullate spidroin protein, and a second protein fragment comprising a fusion partner and a cleavage agent recognition site. The first protein fragment is coupled via said cleavage agent recognition site to the fusion partner. The invention also provides a method of producing a major ampullate spidroin protein and polymers thereof.
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| 10. |
- Larsson, Mårten, et al.
(författare)
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Selective interaction of megalin with postsynaptic density-95 (PSD-95)-like membrane-associated guanylate kinase (MAGUK) proteins
- 2003
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Ingår i: Biochemical Journal. - 0264-6021 .- 1470-8728. ; 373:2, s. 381-391
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Tidskriftsartikel (refereegranskat)abstract
- Megalin is an integral membrane receptor belonging to the low-density lipoprotein receptor family. In addition to its role as an endocytotic receptor, megalin has also been proposed to have signalling functions. Using interaction cloning in yeast, we identified the membrane-associated guanylate kinase family member postsynaptic density-95 (PSD-95) as an interaction partner for megalin. PSD-95 and a truncated version of megalin were co-immunoprecipitated from HEK-293 cell lysates overexpressing the two proteins, which confirmed the interaction. The two proteins were found to be co-localized in these cells by confocal microscopy. Immunocytochemical studies showed that cells in the parathyroid, proximal tubuli of the kidney and placenta express both megalin and PSD-95. We found that the interaction between the two proteins is mediated by the binding of the C-terminus of megalin, which has a type I PSD-95/ Drosophila discs-large/zona occludens 1 (PDZ)-binding motif, to the PDZ2 domain of PSD-95. The PSD-95-like membrane-associated guanylate kinase ('MAGUK') family contains three additional members: PSD-93, synapse-associated protein 97 (SAP97) and SAP102. We detected these proteins, apart from SAP102, in parathyroid chief cells, a cell type having a marked expression of megalin. The PDZ2 domains of PSD-93 and SAP102 were also shown to interact with megalin, whereas no interaction was detected for SAP97. The SAP97 PDZ2 domain differed at four positions from the other members of the PSD-95 subfamily. One of these residues was Thr(389), located in the alphaB-helix and part of the hydrophobic pocket of the PDZ2 domain. Surface plasmon resonance experiments revealed that mutation of SAP97 Thr(389) to alanine, as with the other PSD-95-like membrane-associated guanylate kinases, induced binding to megalin.
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