| 1. |
- Thomas, HS, et al.
(författare)
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- 2019
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swepub:Mat__t
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| 2. |
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| 3. |
- Ademuyiwa, Adesoji O., et al.
(författare)
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Determinants of morbidity and mortality following emergency abdominal surgery in children in low-income and middle-income countries
- 2016
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Ingår i: BMJ Global Health. - : BMJ Publishing Group Ltd. - 2059-7908. ; 1:4
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Tidskriftsartikel (refereegranskat)abstract
- Background: Child health is a key priority on the global health agenda, yet the provision of essential and emergency surgery in children is patchy in resource-poor regions. This study was aimed to determine the mortality risk for emergency abdominal paediatric surgery in low-income countries globally.Methods: Multicentre, international, prospective, cohort study. Self-selected surgical units performing emergency abdominal surgery submitted prespecified data for consecutive children aged <16 years during a 2-week period between July and December 2014. The United Nation's Human Development Index (HDI) was used to stratify countries. The main outcome measure was 30-day postoperative mortality, analysed by multilevel logistic regression.Results: This study included 1409 patients from 253 centres in 43 countries; 282 children were under 2 years of age. Among them, 265 (18.8%) were from low-HDI, 450 (31.9%) from middle-HDI and 694 (49.3%) from high-HDI countries. The most common operations performed were appendectomy, small bowel resection, pyloromyotomy and correction of intussusception. After adjustment for patient and hospital risk factors, child mortality at 30 days was significantly higher in low-HDI (adjusted OR 7.14 (95% CI 2.52 to 20.23), p<0.001) and middle-HDI (4.42 (1.44 to 13.56), p=0.009) countries compared with high-HDI countries, translating to 40 excess deaths per 1000 procedures performed.Conclusions: Adjusted mortality in children following emergency abdominal surgery may be as high as 7 times greater in low-HDI and middle-HDI countries compared with high-HDI countries. Effective provision of emergency essential surgery should be a key priority for global child health agendas.
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| 5. |
- Uvdal, Kajsa, et al.
(författare)
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Vapor deposited polyaniline
- 1989
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Ingår i: Synthetic metals. - : Elsevier. - 0379-6779 .- 1879-3290. ; 29:1, s. 451-456
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Tidskriftsartikel (refereegranskat)abstract
- We have prepared thin films of polyaniline (emeraldine base) by an open boat evaporation process. These vapor-deposited films have a higher molecular weight than expected from a vapor deposition process, indicating a post deposition chemical process. The films have optical properties very similar to, but not identical to, these of “conventional†emeraldine. After treatment with protonic acid, the films exhibit an electrical conductivity of up to about 10% of that of conventional emeraldine salt.
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| 7. |
- Park, Juwon, et al.
(författare)
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The Tcf21 lineage constitutes the lung lipofibroblast population
- 2019
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Ingår i: American Journal of Physiology - Lung cellular and Molecular Physiology. - : AMER PHYSIOLOGICAL SOC. - 1040-0605 .- 1522-1504. ; 316:5, s. L872-L885
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Tidskriftsartikel (refereegranskat)abstract
- Transcription factor 21 (Tcf21) is a basic helix-loop-helix transcription factor required for mesenchymal development in several organs. Others have demonstrated that Tcf21 is expressed in embryonic lung mesenchyme and that loss of Tcf21 results in a pulmonary hypoplasia phenotype. Although recent single-cell transcriptome analysis has described multiple mesenchymal cell types in the lung, few have characterized the Tcf21 expressing population. To explore the Tcf21 mesenchymal lineage, we traced Tcf21-expressing cells during embryogenesis and in the adult. Our results showed that Tcf21 progenitor cells at embryonic day (E) 11.5 generated a subpopulation of fibroblasts and lipofibroblasts and a limited number of smooth muscle cells. After E15.5, Tcf21 progenitor cells exclusively become lipofibroblasts and interstitial fibroblasts. Lipid metabolism genes were highly expressed in perinatal and adult Tcf21 lineage cells. Overexpression of Tcf21 in primary neonatal lung fibroblasts led to increases in intracellular neutral lipids, suggesting a regulatory role for Tcf21 in lipofibroblast function. Collectively, our results reveal that Tcf21 expression after E15.5 delineates the lipofibroblast and a population of interstitial fibroblasts. The Tcf21 inducible Cre mouse line provides a novel method for identifying and manipulating the lipofibroblast.
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| 8. |
- Sennstrom, M., et al.
(författare)
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Thromboembolism and in vitro fertilization - a systematic review
- 2017
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Ingår i: Acta Obstetricia Et Gynecologica Scandinavica. - : Wiley. - 0001-6349 .- 1600-0412. ; 96:9, s. 1045-1052
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Forskningsöversikt (refereegranskat)abstract
- IntroductionThere is no accepted consensus on thromboprophylaxis in relation to in vitro fertilization (IVF). We aimed to study the frequency of thromboembolism and to assess thromboprophylaxis in relation to IVF. Material and methodsWe performed a systematic review. All study designs were accepted except single case reports. Language of included articles was restricted to English. ResultsOf 338 articles, 21 relevant articles (nine cohort studies, six case-control studies, three case series, and three reviews of case series) were identified. The antepartum risk of venous thromboembolism (VTE) after IVF is doubled (odds ratio 2.18, 95% CI 1.63-2.92), compared with the background pregnant population. This is due to a 5- to 10-fold increased risk during the first trimester in IVF pregnancies, in turn related to a very high risk of VTE after ovarian hyperstimulation syndrome (OHSS), i.e. up to a 100-fold increase, or an absolute risk of 1.7%. The interval from embryo transfer to VTE was 3-112 days and the interval from embryo transfer to arterial thromboembolism was 3-28 days. No robust study on thromboprophylaxis was found. ConclusionsThe antepartum risk of VTE after IVF is doubled, compared with the background pregnant population, and is in turn related to a very high risk of VTE after OHSS in the first trimester. We recommend that IVF patients with OHSS be prescribed low-molecular-weight heparin during the first trimester, whereas other IVF patients should be given thromboprophylaxis based on the same risk factors as other pregnant women.
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| 9. |
- Thörnblom, Kristian, 1976, et al.
(författare)
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The extractability of phenolic antioxidants into water and organic solvents from polyethylene pipe materials - Part I
- 2011
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Ingår i: Polymer Degradation and Stability. - : Elsevier BV. - 0141-3910. ; 96:10, s. 1751-1760
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Tidskriftsartikel (refereegranskat)abstract
- Three commercial anti-oxidant systems have been studied regarding migration and chemical reaction in different polyethylene pipe materials during extraction in organic solvents and in hot water, 95-100 degrees C, under anaerobic and aerobic conditions. Materials made of crosslinked and non-crosslinked high density polyethylene, low density polyethylene and blends thereof were stabilized with different phenolic antioxidants: Irganox 1330, Irganox 1010, and Irganox 1076. The loss in stability with increasing extraction times was followed by oxidation induction time (OIT) measurements and by measuring the residual amounts of anti-oxidant by extraction. A gradual decrease in OIT and amount of anti-oxidant with increasing treatment time in water was observed for all samples. However, the behaviour of the three antioxidants was dissimilar. For materials containing Irganox 1330 three new species, possibly transformation products of the anti-oxidant, were found within the material. Larger decrease in antioxidant content in the polymer compared to corresponding loss in OIT indicates that the new species still have anti-oxidant capacity. On the other hand, corresponding transformation species could not be found within materials stabilized with Irganox 1010 or 1076. It is suggested that these antioxidants, which both contain ester groups, are hydrolyzed and that the new species migrate out into the surrounding water. Solvent extractions showed that crosslinking did not affect the extractability of the antioxidants. Actually, even with water as the extracting media, the network did not show any obstructive effect of the migration of the anti-oxidant. For peroxide crosslinked samples part of the antioxidant could not be extracted with solvent but we believe that grafting of antioxidants onto the polymer backbone is the most plausible explanation in this case. Additionally, we see a clear decrease in antioxidant loss with increasing crystallinity.
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