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- Nilsson, G., et al.
(författare)
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Demonstration of mast-cell chemotactic activity in nasal lavage fluid : characterization of one chemotaxin as c-kit ligand, stem cell factor
- 1998
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Ingår i: Allergy. European Journal of Allergy and Clinical Immunology. - : Wiley. - 0105-4538 .- 1398-9995. ; 53:9, s. 874-879
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Tidskriftsartikel (refereegranskat)abstract
- Mast cells are known to accumulate in tissue during allergic inflammation. However, the chemotaxins responsible are undefined. Using a modified Boyden chamber and the human mast-cell line HMC-1, we first identified mast-cell chemotactic activity in nasal lavage fluid collected before the pollen season after allergen provocation of allergic patients (n=29) (mean migratory response compared to medium control was 121%, range 85-198%). Mast-cell chemotactic activity was also detected in lavage fluid collected after allergen provocation at the end of a Swedish birch-pollen season from three different treatment groups: topical steroid treatment with budesonide; the topical antihistamine, levocabastine; and placebo. There was no significant difference in mast-cell chemotactic activity between nasal lavage fluid collected from the placebo group (mean=102%), the budesonide-treated group (mean=114%), or the levocabastine group (mean=125%). Stem cell factor (SCF), a known mast-cell chemotaxin, was present in the nasal lavage fluids from all three groups, and correlated with the mast-cell chemotactic activity (r=0.67, P<0.01). The mast-cell chemotactic activity was inhibited (range 5-100%) in some, but not all, nasal lavage fluids by a polyclonal antibody directed against SCF. This report describes the presence of mast-cell chemotactic activity in nasal lavage fluid during an allergic reaction. These findings show that SCF may play a pivotal role in the recruitment of mast cells in allergic rhinitis.
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- THULIN, M, et al.
(författare)
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ECHIDNOPSIS GLOBOSA SP-NOV (ASCLEPIADACEAE-STAPELIEAE) FROM YEMEN
- 1995
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Ingår i: NORDIC JOURNAL OF BOTANY. - : NORDIC JOURNAL OF BOTANY. - 0107-055X. ; 15:3, s. 261-262
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- The new species Echidnopsis globosa from rocky hillsides on Limestone in the Hadramaut Region in Yemen is described and illustrated. It belongs to a group of species including E. squamulata from Yemen and E. ericiflora from Kenya, but is unique in the gen
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