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Sökning: WFRF:(Hoffman Moshe)

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  • Biram, Adi, et al. (författare)
  • Bacterial infection disrupts established germinal center reactions through monocyte recruitment and impaired metabolic adaptation.
  • 2022
  • Ingår i: Immunity. - : Elsevier BV. - 1097-4180 .- 1074-7613. ; 55:3
  • Tidskriftsartikel (refereegranskat)abstract
    • Consecutive exposures to different pathogens are highly prevalent and often alter the host immune response. However, it remains unknown how a secondary bacterial infection affects an ongoing adaptive immune response elicited against primary invading pathogens. We demonstrated that recruitment of Sca-1+ monocytes into lymphoid organs during Salmonella Typhimurium (STm) infection disrupted pre-existing germinal center (GC) reactions. GC responses induced by influenza, plasmodium, or commensals deteriorated following STm infection. GC disruption was independent of the direct bacterial interactions with B cells and instead was induced through recruitment of CCR2-dependent Sca-1+ monocytes into the lymphoid organs. GC collapse was associated with impaired cellular respiration and was dependent on TNFα and IFNγ, the latter of which was essential for Sca-1+ monocyte differentiation. Monocyte recruitment and GC disruption also occurred during LPS-supplemented vaccination and Listeria monocytogenes infection. Thus, systemic activation of the innate immune response upon severe bacterial infection is induced at the expense of antibody-mediated immunity.
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  • Dreber Almenberg, Anna, et al. (författare)
  • Androgens and competitiveness in men
  • 2011
  • Ingår i: Journal of Neuroscience, Psychology, and Economics. - : American Psychological Association. - 1937-321X .- 2151-318X. ; 4:1, s. 54-62
  • Tidskriftsartikel (refereegranskat)abstract
    • In this study, we investigate the association between a number of hormonal variables (circulating testosterone, facial masculinity, 2D:4D digit ratio, and cortisol) and competitiveness in a sample of 93 men aged 18–23. Competitiveness is measured by self-selection into a competitive setting versus a piece-rate scheme. We find no robust correlations between any of the hormonal variables and competiveness, though there are some suggestive patterns in the data which merit further exploration. (APA PsycInfo Database Record (c) 2016 APA, all rights reserved)
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