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- Baldewpersad Tewarie, N., et al.
(författare)
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An overview of Clinical Quality Registries (CQRs) on gynecological oncology worldwide
- 2022
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Ingår i: European Journal of Surgical Oncology. - : Elsevier BV. - 0748-7983. ; 48:10, s. 2094-2103
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Forskningsöversikt (refereegranskat)abstract
- Introduction: Clinical Quality Registries (CQRs) were initiated in order to compare clinical outcomes between hospitals or regions within a country. To get an overview of these CQRs worldwide the aim of this study was to identify these CQRs for gynecological oncology and to summarize their characteristics, processes and QI's and to establish whether it is feasible to make an international comparison in the future. Methods: To identify CQRs in gynecological oncology a literature search in Pubmed was performed. All papers describing the use of a CQR were included. Administrative, epidemiological and cancer registries were excluded as these registries do not primarily serve to measure quality of care through QI's. The taskforce or contact person of the included CQR were asked to participate and share information on registered items, processes and indicators. Results: Five nations agreed to collaborate: Australia, Denmark, Italy, the Netherlands and Sweden. Denmark, Netherlands and Sweden established a nationwide registry, collecting data on multiple tumor types, and various QI's. Australia and Italy included patients with ovarian cancer only. All nations had a different process to report feedback results to participating hospitals. Conclusion: CQRs serve the same purpose to improve quality of care but vary on different aspects. Although similarities are observed in the topics measured by the QI's, an international comparison was not feasible as numerators or denominators differ between registries. In order to compare on an international level it would be useful to harmonize these registries and to set an international standard to measure the quality of care with similar indicators.
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- Bergstrom, S., et al.
(författare)
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J-factors for self-interacting dark matter in 20 dwarf spheroidal galaxies
- 2018
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Ingår i: Physical Review D. - 2470-0010 .- 2470-0029. ; 98:4
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Tidskriftsartikel (refereegranskat)abstract
- Dwarf spheroidal galaxies are among the most promising targets for indirect dark matter (DM) searches in gamma rays. The gamma-ray flux from DM annihilation in a dwarf spheroidal galaxy is proportional to the J-factor of the source. The J-factor of a dwarf spheroidal galaxy is the line-of-sight integral of the DM mass density squared times /(0), where sigma(ann)v(rel) is the DM annihilation cross-section times relative velocity v(rel) = vertical bar v(rel)vertical bar angle brackets denote average over v(rel), and (sigma(ann)v(rel)) is the v(rel)-independent part of sigma(ann)v(rel). If sigma(ann)v(rel) is constant in v(rel), J-factors only depend on the DM space distribution in the source. However, if sigma(ann)v(rel) varies with v(rel), as in the presence of DM self-interactions, J-factors also depend on the DM velocity distribution, and on the strength and range of the DM self-interaction. Models for self interacting DM are increasingly important in the study of the small scale clustering of DM, and are compatible with current astronomical and cosmological observations. Here we derive the J-factor of 20 dwarf spheroidal galaxies from stellar kinematic data under the assumption of Yukawa DM self-interactions. J-factors are derived through a profile likelihood approach, assuming either NavarroFrenk-White (NEW) or cored DM profiles. We also compare our results with J-factors derived assuming the same velocity for all DM particles in the target galaxy. We find that this common approximation overestimates the Mactors by up to 1 order of magnitude. J-factors for a sample of DM particle masses and self-interaction coupling constants, as well as for NFW and cored density profiles, are provided electronically, ready to he used in other projects.
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