| 1. |
- Alexius, Katarina, et al.
(författare)
-
Forskare: Ge socialtjänsten rätt verktyg
- 2015
-
Ingår i: Svenska dagbladet. - Stockholm. - 1101-2412. ; :2015-12-11
-
Tidskriftsartikel (populärvet., debatt m.m.)abstract
- Att socialtjänstens personal kan hantera och tolka nyckelbegrepp som ”barnets bästa” och ”god vård” är helt avgörande för förstärkningar av barns reella rättigheter, skriver forskare vid Stockholms universitet och Ersta Sköndal högskola.
|
|
| 2. |
- Bjork Thordardottir, Edda, et al.
(författare)
-
Mortality and major disease risk among migrants of the 1991-2001 Balkan wars to Sweden : A register-based cohort study
- 2020
-
Ingår i: PLoS Medicine. - : Public Library of Science (PLoS). - 1549-1277 .- 1549-1676. ; 17:12
-
Tidskriftsartikel (refereegranskat)abstract
- Background: In recent decades, millions of refugees and migrants have fled wars and sought asylum in Europe. The aim of this study was to quantify the risk of mortality and major diseases among migrants during the 1991-2001 Balkan wars to Sweden in comparison to other European migrants to Sweden during the same period.Methods and findings: We conducted a register-based cohort study of 104,770 migrants to Sweden from the former Yugoslavia during the Balkan wars and 147,430 migrants to Sweden from 24 other European countries during the same period (1991-2001). Inpatient and specialized outpatient diagnoses of cardiovascular disease (CVD), cancer, and psychiatric disorders were obtained from the Swedish National Patient Register and the Swedish Cancer Register, and mortality data from the Swedish Cause of Death Register. Adjusting for individual-level data on sociodemographic characteristics and emigration country smoking prevalence, we used Cox regressions to contrast risks of health outcomes for migrants of the Balkan wars and other European migrants. During an average of 12.26 years of follow-up, being a migrant of the Balkan wars was associated with an elevated risk of being diagnosed with CVD (HR 1.39, 95% CI 1.34-1.43, p < 0.001) and dying from CVD (HR 1.45, 95% CI 1.29-1.62, p < 0.001), as well as being diagnosed with cancer (HR 1.16, 95% CI 1.08-1.24, p < 0.001) and dying from cancer (HR 1.27, 95% CI 1.15-1.41, p < 0.001), compared to other European migrants. Being a migrant of the Balkan wars was also associated with a greater overall risk of being diagnosed with a psychiatric disorder (HR 1.19, 95% CI 1.14-1.23, p < 0.001), particularly post-traumatic stress disorder (HR 9.33, 95% CI 7.96-10.94, p < 0.001), while being associated with a reduced risk of suicide (HR 0.68, 95% CI 0.48-0.96, p = 0.030) and suicide attempt (HR 0.57, 95% CI 0.51-0.65, p < 0.001). Later time period of migration and not having any first-degree relatives in Sweden at the time of immigration were associated with greater increases in risk of CVD and psychiatric disorders. Limitations of the study included lack of individual-level information on health status and behaviors of migrants at the time of immigration.Conclusions: Our findings indicate that migrants of the Balkan wars faced considerably elevated risks of major diseases and mortality in their first decade in Sweden compared to other European migrants. War migrants without family members in Sweden or with more recent immigration may be particularly vulnerable to adverse health outcomes. Results underscore that persons displaced by war are a vulnerable group in need of long-term health surveillance for psychiatric disorders and somatic disease.
|
|
| 3. |
- Ekman, Anna-Theresia, et al.
(författare)
-
Prevalence of children under five with disabilities in Sierra Leone in 2017: Insights from a population-based multiple indicator cluster survey
- 2023
-
Ingår i: Disability and Health Journal. - : ELSEVIER SCIENCE INC. - 1936-6574 .- 1876-7583. ; 16:4
-
Tidskriftsartikel (refereegranskat)abstract
- Background: Children with disabilities have been low on the agenda of child health, including in Sierra Leone, and there are still many gaps in our knowledge and understanding of the issue.Objective: To estimate the prevalence of children with disabilities in Sierra Leone using functional difficulty as a proxy and to understand the factors associated with disabilities among children two to four years living in Sierra Leone.Methods: We used cross-sectional data from the Sierra Leone 2017 Multiple Indicator Cluster Survey. Disability was defined using a functional difficulty definition with additional thresholds used to define children with severe functional difficulty and multiple disabilities. Logistic regression models estimated odds ratios (ORs) of childhood disability and how they were associated with socioeconomic factors and living conditions.Results: Prevalence of children with disabilities was 6.6% (95% confidence interval (CI) 5.8-7.6%) and there was a high risk of comorbidity between different functional difficulties. Children with disabilities were less likely to be girls (adjusted odds ratio (AOR) 0.8 (CI 0.7-1.0) and older (AOR 0.3 (CI 0.2-0.4)), but more prone to be stunted (AOR 1.4 (CI 1.1-1.7)) and have younger caregivers (AOR 1.3 (CI 0.7-2.3)).Conclusion: The prevalence of disabilities in young Sierra Leonean children was comparable to other countries in West and Central Africa when using the same measure of disability. Preventive as well as early detection and intervention efforts are recommended to be integrated with other programs, e.g vaccinations, nutrition, and poverty reducing programs.(c) 2023 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
|
|
| 4. |
- Fridström Montoya, Therése, 1973-
(författare)
-
Leva som andra genom ställföreträdare : en rättslig och faktisk paradox
- 2015
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- In the past, people with intellectual disabilities have been treated as objects, rather than subjects, of law. Today, Swedish law purports to recognize that such persons have the same rights and freedoms as anyone else. To achieve this goal, Sweden’s social welfare law provides persons with intellectual disabilities a right to the support and service they need to “be able to live like others do”. For persons who lack the capability to apply for these measures because they lack the capabilities or do not meet the prerequisites to be a legal actor, a legal representative is needed.This dissertation examines the problem reflected in the constructed expression “ability to live like others do through legal representation”, first through traditional legal analysis of its implementation in Swedish law, followed by a critical theoretical analysis of that law. The dissertation shows how Swedish law does not resolve the conflict between legal capacity and actual capabilities for people with intellectual disabilities, as it ratifies dependence on others for access to social welfare rights for people with intellectual disabilities in order for them to be taken seriously as legal actors and subjects before the law. The dissertation proposes a rethinking of the law from a Crip Theory perspective, which questions the able-mindedness norm of the legal subject. The dissertation argues that Swedish law exemplifies this norm as a reflection of power that produces and reproduces a certain kind of legal subject through normalization mechanisms. This dissertation shows that barriers still remain to the realization of full legal capacity for persons with intellectual disabilities, and to the possibilities for such persons to be recognized as self-determinate subjects in law.
|
|
| 5. |
- Lok, Veeleah, et al.
(författare)
-
Changes in anxiety and depression during the COVID-19 pandemic in the European population : A meta-analysis of changes and associations with restriction policies
- 2023
-
Ingår i: European psychiatry. - 0924-9338 .- 1778-3585. ; 66:1
-
Forskningsöversikt (refereegranskat)abstract
- Background. Early studies of common mental disorders (CMDs) during the COVID-19 pandemic mainly report increases; however, more recent findings have been mixed. Also, studies assessing the effects of restriction measures on CMDs show varied results. The aim of this meta-analysis was to assess changes in levels of CMDs from pre-/early to during the pandemic and the effects of restriction policies in the European population.Methods. We searched for studies assessing both pre-pandemic and peri-pandemic self-reported emotional distress and symptoms of depression or anxiety among nationally/regionally representative samples in Europe and collected microdata from those studies. Estimates of corona containment index were related to changes in CMDs using random-effects meta-regression.Results. Our search strategy resulted in findings from 15 datasets drawn from 8 European countries being included in the meta-analysis. There was no evidence of change in the prevalence of emotional distress, anxiety, or depression from before to during the pandemic; but from early pandemic periods to later periods, there were significant decreases in emotional distress and anxiety. Increased school restrictions and social distancing were associated with small increases in self-reported emotional distress.Conclusions. Despite initial concerns of increased emotional distress and mental illness due to the COVID-19 pandemic, the results from this meta-analysis indicate that there was a decrease in emotional distress and no change in anxiety or depression in the general population in Europe. Overall, our findings support the importance of strong governance when implementing periodic and robust restriction measures to combat the spread of COVID-19.
|
|
| 6. |
- Nikkarinen, Anna, et al.
(författare)
-
Soluble CD163 predicts outcome in both chemoimmunotherapy and targeted therapy-treated mantle cell lymphoma
- 2023
-
Ingår i: Blood Advances. - : American Society of Hematology. - 2473-9529 .- 2473-9537. ; 7:18, s. 5304-5313
-
Tidskriftsartikel (refereegranskat)abstract
- The outcome for patients with mantle cell lymphoma (MCL) has drastically improved with new treatments directed toward the tumor immune microenvironment, where macrophages play an important role. In MCL, the presence of M2 macrophages defined by CD163 expression in diagnostic biopsies has been associated with a worse prognosis. An alternative way to assess the abundance of M2 macrophages is by measuring the level of soluble CD163 in serum (sCD163). We aimed to investigate the prognostic value of sCD163 in 131 patients with MCL. We found that high sCD163 at diagnosis was associated with shorter progression-free survival (PFS) and shorter overall survival (OS) in 81 patients who were newly diagnosed and subsequently treated with chemoimmunotherapy. The same was seen in a cohort of 50 patients with relapsed MCL that were mainly treated within the phase 2 Philemon-trial with rituximab, ibrutinib, and lenalidomide. In patients who were newly diagnosed and had low levels of sCD163, 5-year survival was 97%. There was a moderate correlation between sCD163 and tissue CD163. The association with a poor prognosis was independent of MCL international prognostic index, Ki67, p53 status, and blastoid morphology, as assessed in a multivariable Cox proportional hazards model. In this study, high sCD163 was associated with both shorter PFS and shorter OS, showing that high levels of the M2 macrophage marker sCD163 is an independent negative prognostic factor in MCL, both in the chemoimmunotherapy and ibrutinib/lenalidomide era. In addition, low sCD163 levels identify patients with MCL with a very good prognosis.
|
|
| 7. |
- Rodrigues, Joana M., et al.
(författare)
-
Infiltration of CD163-, PD-L1-and FoxP3-positive cells adversely affects outcome in patients with mantle cell lymphoma independent of established risk factors
- 2021
-
Ingår i: British Journal of Haematology. - : John Wiley & Sons. - 0007-1048 .- 1365-2141. ; 193:3, s. 520-531
-
Tidskriftsartikel (refereegranskat)abstract
- We characterised patients with mantle cell lymphoma (MCL) with poor prognosis based on differences in immune infiltration. Different expressions of the tumour cell markers Cyclin D1 and sex-determining region Y-box transcription factor 11 (SOX11), and the immune markers cluster of differentiation 3 (CD3), CD4, CD8, CD25, forkhead box protein P3 (FoxP3), T-box transcription factor TBX21 (T-bet), programmed cell death protein 1 (PD-1), programmed-death ligand 1 (PD-L1) and CD163 were investigated for all-cause mortality in 282 patients with MCL and time-to-progression (TTP) in 106 clinical trial patients. With increasing age, a significantly lower infiltration of CD3(+) T lymphocytes was seen. T-cell infiltration was independent of cellular tumour antigen p53 (p53) expression, Ki-67, morphology and frequency of tumour cells. The all-cause mortality was higher in patients with PD-L1-expression above cut-off [hazard ratio (HR) 1 center dot 97, 95% confidence interval (CI) 1 center dot 18-3 center dot 25, adjusted for sex and MCL International Prognostic Index (MIPI)] and a higher frequency of CD163(+) cells (continuously, HR 1 center dot 51, 95% CI 1 center dot 03-2 center dot 23, adjusting for age, sex, morphology, Ki-67 and p53). In patients treated within the Nordic Lymphoma Group MCL2/3 trials, TTP was shorter in patients with a higher frequency of FoxP3(+) cells (HR 3 center dot 22, 95% CI 1 center dot 40-7 center dot 43) and CD163(+) cells (HR 6 center dot 09, 95% CI 1 center dot 84-20 center dot 21), independent of sex and MIPI. When combined a higher frequency of CD163(+) macrophages and PD-L1(+) cells or high CD163(+) macrophages and FoxP3(+) regulatory T cells indicated worse outcome independent of established risk factors. The T-cell infiltrate was in turn independent of molecular characteristics of the malignant cells and decreased with age.
|
|
| 8. |
- Alexius Borgström, Katarina, 1967-, et al.
(författare)
-
Rättsvetenskapliga metoder
- 2005
-
Ingår i: Forskningsmetoder i socialt arbete. - Lund : Studentlitteratur. - 9144033192 ; , s. 129-151
-
Bokkapitel (övrigt vetenskapligt/konstnärligt)
|
|
| 9. |
- Alexius, Katarina, 1967-, et al.
(författare)
-
Barns behov och vilja vid tvångsvård till följd av omsorgsbrist
- 2014. - 1
-
Ingår i: Barnrätt : en antologi. - Stockholm : Norstedts Juridik AB. - 9789139017813 ; , s. 21-38
-
Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Vid omhändertaganden av barn ska barnets bästa vara avgörande för de beslut som fattas. I den praktiska tillämpningen innefattar begreppet ofta tolkningar av barns behov, såsom dessa definieras av kompetenta vuxna, och barnets vilja, såsom denna uttrycks av barnet eller uttolkas av vuxna. I denna studie undersöks uttrycken barns behov och vilja samt hur barns behov och vilja bedöms i sociala utredningar och domar som rör tvångsomhändertaganden till följd av omsorgssvikt av barn i familjer där någon förälder har intellektuell funktionsnedsättning.
|
|
| 10. |
- Alexius, Katarina, 1967-, et al.
(författare)
-
Care assessments concerning involuntary removal of children from intellectually disabled parents
- 2014
-
Ingår i: Journal of Social Welfare and Family Law. - : Informa UK Limited. - 0964-9069 .- 1469-9621. ; 36:3, s. 295-310
-
Tidskriftsartikel (refereegranskat)abstract
- This study set out to analyse how parenting and the needs of the children are assessed by social authorities and courts in families where one or both parents have an intellectual disability (ID). The texts of child welfare investigations and court judgements in 16 cases of care orders concerning parents (30) with IDs and their children (29) in two counties in Sweden were analysed by a hermeneutic case study. The study shows that even though many of the children are described as already harmed by neglect, clear assessments of care needs are not presented and it is uncertain which of the children’s needs a placement in a family home is assumed to satisfy. The conclusion of the article is that, even though no direct discrimination can be established, the particular individual and structural difficulties of the families’ life circumstances are not taken into consideration. This can be seen as a discriminatory practice.
|
|
