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| 2. |
- Anderson, Helén, et al.
(författare)
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Skapa kundnärvaro i innovationsprocessen
- 2008
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Ingår i: Innovationsförmåga. - Malmö : Holmbergs i Malmö AB. - 9789197785204 ; , s. 40-59
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Bokkapitel (populärvet., debatt m.m.)
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| 3. |
- Dahlstedt, Magnus, et al.
(författare)
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Systemet med fritt skolval måste bytas ut
- 2018
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Ingår i: Svenska Dagbladet.
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- Ökad segregation och deprofessionalisering av läraryrket är några av effekterna av det fria skolvalet. Nu krävs en grundlig utredning med siktet inställt på att hitta alternativ till nuvarande marknadssystem, skriver ett flertal forskare.
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| 4. |
- Ekberg, Joakim, et al.
(författare)
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Impact of precautionary behaviors during outbreaks of pandemic influenza : modeling of regional differences
- 2009
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Ingår i: AMIA Annual Symposium Proceedings. - Rockville Pike, Bethesda MD, 20894 USA : American Medical Informatics Association. - 1942-597X. ; 2009, s. 163-167
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Tidskriftsartikel (refereegranskat)abstract
- Using time geographic theory for representation of population mixing, we set out to analyze the relative impact from precautionary behaviors on outbreaks of pandemic influenza in Europe and Asia. We extended an existing simulator environment with behavioral parameters from a population survey to model different behaviors. We found that precautionary behaviors even among a minority of the population can have a decisive effect on the probability of the outbreak to propagate. The results also display that assumptions strongly influences the outcome. Depending on the interpretation of how many "children" are kept from "school", R(0) changes from a range where outbreak progression is possible to a range where it is improbable in both European (R(0)=1.77/1.23) and Asian (R(0)=1.70/1.05) conditions. We conclude that unprompted distancing can have a decisive effect on pandemic propagation. An important response strategy can be to promote voluntary precautionary behavior shown to reduce disease transmission.
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| 5. |
- Gustavsson, Patrik, 1988-
(författare)
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Virtual Reality Platform for Design and Evaluation of the Interaction in Human-Robot Collaborative Tasks in Assembly Manufacturing
- 2020
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Industry is on the threshold of the fourth industrial revolution where smart factories area necessity to meet customer demands for increasing volumes of individualized products. Within the smart factory, cyber-physical production systems are becoming important to deal with changing production. Human-robot collaboration is an example of a cyber-physical system in which humans and robots share a workspace. By introducing robots and humans into the same working cell, the two can collaborate by allowing the robot to deal with heavy lifting, repetitive, and high accuracy tasks, while the human focuses on tasks that need intelligence, flexibility, and adaptability. There are few such collaborative applications in industry today. In the implementations that actually exist, the robots are mainly working side-by-side with humans rather than truly collaborating. Three main factors that limit the widespread application of human-robot collaboration can be identified: lack of knowledge regarding suitable human-robot collaboration tasks, lack of knowledge regarding efficient communication technologies for enabling interaction between humans and robots when carrying out tasks, and lack of efficient ways to safely analyze and evaluate collaborative tasks.The overall aim of this thesis is to address these problems and facilitate and improve interaction between humans and robots, with a special focus on assembly manufacturing tasks. To fulfill this aim, an assembly workstation for human-robot collaboration has been developed and implemented both physically and virtually. A virtual reality platform called ViCoR has been developed that can be used to investigate, evaluate, and analyze the interaction between humans and robots and thereby facilitate the implementation of new human-robot collaboration cells. The workstation developed has also been used for data collection and experiments during the thesis work, and used to extract knowledge of how the interaction between human and robot can be improved.
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| 6. |
- Liu, Hebin, et al.
(författare)
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AML1/Runx1 recruits calcineurin to regulate granulocyte macrophage colony-stimulating factor by Ets1 activation.
- 2004
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Ingår i: Journal of Biological Chemistry. - 0021-9258 .- 1083-351X. ; 279:28, s. 29398-29408
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Tidskriftsartikel (refereegranskat)abstract
- Acute myeloid leukemia 1 (AML1), also denoted Runx1, is a transcription factor essential for hematopoiesis, and the AML1 gene is the most common target of chromosomal translocations in human leukemias. AML1 binds to sequences present in the regulatory regions of a number of hematopoiesis-specific genes, including certain cytokines such as granulocyte macrophage colony-stimulating factor (GM-CSF) up-regulated after T cell receptor stimulation. Here we show that both subunits of the Ca(2+)/calmodulin-dependent protein phosphatase calcineurin (CN), which is activated upon T cell receptor stimulation, interact directly with the N-terminal runt homology domain-containing part of AML1. The regulatory CN subunit binds AML1 with a higher affinity and in addition also interacts with the isolated runt homology domain. The related Runx2 transcription factor, which is essential for bone formation, also interacts with CN. A constitutively active derivative of CN is shown to activate synergistically the GM-CSF promoter/enhancer together with AML1 or Runx2. We also provide evidence that relief of the negative effect of the AML1 sites is important for Ca(2+) activation of the GM-CSF promoter/enhancer and that AML1 overexpression increases this Ca(2+) activation. Both subunits of CN interact with AML1 in coimmunoprecipitation analyses, and confocal microscopy analysis of cells expressing fluorescence-tagged protein derivatives shows that CN can be recruited to the nucleus by AML1 in vivo. Mutant analysis of the GM-CSF promoter shows that the Ets1 binding site of the promoter is essential for the synergy between AML1 and CN in Jurkat T cells. Analysis of the effects of inhibitors of the protein kinase glycogen synthase kinase-3beta and in vitro phosphorylation/dephosphorylation analysis of Ets1 suggest that glycogen synthase kinase-3beta-phosphorylated Ets1 is a target of AML1-recruited CN phosphatase at the GM-CSF promoter.
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| 7. |
- Olsson, Magnus, et al.
(författare)
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Strategic Growth of Industrial Design Consultancy. A study of changes in the ID consultancy in a post-industrial society
- 2009
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Ingår i: Design Connexity. - Aberdeen, Scotland.
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Konferensbidrag (refereegranskat)abstract
- Based on a study of Swedish and Finnish industrial design consultancies (IDCs) we discuss how changes in industry have affected id-consultancies cope with growth, organizational and management issues. The traditional industrial designer worked in a small consultancy mainly with clients focusing on mass-produced products. The clients were basically domestic even if they operated worldwide. Investment in technology, for instance CAD and rapid prototyping, required larger investments and many id-consultancies saw a need to expand in order to afford these investments. The growth trend will probably continue, with further demands on management skills and this will also, most likely, affect also the small design firms. The design maturity of the client firms is increasing which will put a higher demand on the professionalization of the design firms. Although design has received more attention and is recognized as a valuable tool for competitiveness, the knowledge about what IDCs do and the value of their work is still mainly restricted to those who have experience working with designers. Many designers still argue that their clients do not see how design and strategies are interconnected. The question is whether the IDCs know how to communicate their competence and contribution to business development and strategy creation. The strategic role of design is not always clear to the client firm, but the question is also if the IDCs are clear about what strategy means in a corporate perspective.
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| 8. |
- Söfteland, John M., 1977, et al.
(författare)
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Longevity of anti-spike and anti-nucleocapsid antibodies after COVID-19 in solid organ transplant recipients compared to immunocompetent controls.
- 2022
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Ingår i: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. - : Elsevier BV. - 1600-6143. ; 22:4, s. 1245-1252
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Tidskriftsartikel (refereegranskat)abstract
- Solid organ transplant recipients (SOTRs) are on lifelong immunosuppression, which may interfere with adaptive immunity to COVID-19. The data on dynamics and duration of antibody response in SOTRs are limited. This longitudinal study examined the longevity of both anti-spike (S)- and anti-nucleocapsid (N)-specific IgG-antibodies after COVID-19 in SOTRs compared to matched immunocompetent persons. SOTRs (n=65) were matched with controls (n=65) for COVID-19 disease severity, age, and sex in order of priority. Serum-IgG-antibodies against N- and S-antigens of SARS-CoV-2 were analyzed. At 1 and 9 months after COVID-19, anti-S-IgG detectability decreased from 91% to 82% in SOTRs versus 100% to 95% in controls, whereas the anti-N-IgG decreased from 63% to 29% in SOTRs versus 89% to 46% in controls. A matched paired analysis showed SOTRs having significantly lower levels of anti-N-IgG at all time points (1-month P=0.007, 3-months P<0.001, 6-months P=0.019 and 9-months P=0.021) but not anti-S-IgG at any time points. A mixed-model analysis confirmed these findings except for anti-S-IgG at one month (p=0.005) and identified severity score as the most important predictor of antibody response. SOTRs mount comparable S-specific, but not N-specific, antibody responses to SARS-CoV-2 infection compared to immunocompetent controls.
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| 9. |
- Tarigopula, Venkapati, et al.
(författare)
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A study of large plastic deformations in dual phase steel using digital image correlation and FE analysis
- 2008
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Ingår i: Experimental mechanics. - : Springer Science and Business Media LLC. - 0014-4851 .- 1741-2765. ; 48:2, s. 181-196
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Tidskriftsartikel (refereegranskat)abstract
- Large plastic deformation in sheets made of dual phase steel DP800 is studied experimentally and numerically. Shear testing is applied to obtain large plastic strains in sheet metals without strain localisation. In the experiments, full-field displacement measurements are carried out by means of digital image correlation, and based on these measurements the strain field of the deformed specimen is calculated. In the numerical analyses, an elastoplastic constitutive model with isotropic hardening and the Cockcroft - Latham fracture criterion is adopted to predict the observed behaviour. The strain hardening parameters are obtained from a standard uniaxial tensile test for small and moderate strains, while the shear test is used to determine the strain hardening for large strains and to calibrate the fracture criterion. Finite Element (FE) calculations with shell and brick elements are performed using the non-linear FE code LS - DYNA. The local strains in the shear zone and the nominal shear stress-elongation characteristics obtained by experiments and FE simulations are compared, and, in general, good agreement is obtained. It is demonstrated how the strain hardening at large strains and the Cockcroft - Latham fracture criterion can be calibrated from the in-plane shear test with the aid of non-linear FE analyses.
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| 10. |
- Timpka, Toomas, et al.
(författare)
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Population-based simulations of influenza pandemics : validity and significance for public health policy
- 2009
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Ingår i: BULLETIN OF THE WORLD HEALTH ORGANIZATION. - 0042-9686 .- 1564-0604. ; 87:4, s. 305-311
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Tidskriftsartikel (refereegranskat)abstract
- Objective To examine the validity and usefulness of pandemic simulations aimed at informing practical decision-making in public health. Methods We recruited a multidisciplinary group of nine experts to assess a case-study simulation of influenza transmission in a Swedish county. We used a non-statistical nominal group technique to generate evaluations of the plausibility, formal validity (verification) and predictive validity of the simulation. A health-effect assessment structure was used as a framework for data collection. Findings The unpredictability, of social order during disasters was not adequately addressed by simulation methods; even minor disruptions of the social order may invalidate key infrastructural assumptions underpinning current pandemic simulation models. Further, a direct relationship between model flexibility and computation time was noted. Consequently, simulation methods cannot, in practice, support integrated modifications of microbiological, epidemiological and spatial submodels or handle multiple parallel scenarios. Conclusion The combination of incomplete surveillance data and simulation methods that neglect social dynamics limits the ability of national public health agencies to provide policy-makers and the general public with the critical and timely information needed during a pandemic.
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